scholarly journals Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels

2015 ◽  
Vol 1 (9) ◽  
pp. e1500758 ◽  
Author(s):  
Thomas J. Hinton ◽  
Quentin Jallerat ◽  
Rachelle N. Palchesko ◽  
Joon Hyung Park ◽  
Martin S. Grodzicki ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Low Cost ◽  
Three Dimensional ◽  
Imaging Data ◽  
Three Dimensional Printing ◽  
Optical Computed Tomography ◽  
Biological Structures ◽  
Open Source Hardware ◽  
Aided Design ◽  
Human Brains

We demonstrate the additive manufacturing of complex three-dimensional (3D) biological structures using soft protein and polysaccharide hydrogels that are challenging or impossible to create using traditional fabrication approaches. These structures are built by embedding the printed hydrogel within a secondary hydrogel that serves as a temporary, thermoreversible, and biocompatible support. This process, termed freeform reversible embedding of suspended hydrogels, enables 3D printing of hydrated materials with an elastic modulus <500 kPa including alginate, collagen, and fibrin. Computer-aided design models of 3D optical, computed tomography, and magnetic resonance imaging data were 3D printed at a resolution of ~200 μm and at low cost by leveraging open-source hardware and software tools. Proof-of-concept structures based on femurs, branched coronary arteries, trabeculated embryonic hearts, and human brains were mechanically robust and recreated complex 3D internal and external anatomical architectures.

Use of three-dimensional printing for simulation in ultrasound education: a scoping review

2020 ◽  
pp. bmjstel-2020-000663
Author(s):  
Patrick Gallagher ◽  
Ryan Smith ◽  
Gillian Sheppard
Keyword(s):  
Scoping Review ◽  
Computer Aided Design ◽  
Low Cost ◽  
Three Dimensional ◽  
Low Frequency ◽  
Imaging Data ◽  
Ultrasound Education ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Dimensional Printing

BackgroundThere is a significant learning curve when teaching ultrasonography to medical trainees; task trainers can help learners to bridge this gap and develop their skills. Three-dimensional printing technology has the potential to be a great tool in the development of such simulators. ObjectiveThis scoping review aimed to identify what 3D-printed models have been used in ultrasound education to date, how they were created and the pros and limitations involved.DesignResearchers searched three online databases to identify 3D-printed ultrasound models used in medical education.ResultsTwelve suitable publications were identified for inclusion in this review. The models from included articles simulated largely low frequency and/or high stakes events, with many models simulating needle guidance procedures. Most models were created by using patient imaging data and a computer-aided design software to print structures directly or print casting molds. The benefits of 3D-printed educational trainers are their low cost, reproducibility, patient specificity and accuracy. The current limitations of this technology are upfront investments and a lack of optimisation of materials.ConclusionsThe use of 3D-printed ultrasound task trainers is in its infancy, and more research is needed to determine whether or not this technology will benefit medical learners in the future.

Fabrication of 3D Temperature Sensor Using Magnetostrictive Inkjet Printhead

2020 ◽  
Vol 64 (5) ◽  
pp. 50405-1-50405-5
Author(s):  
Young-Woo Park ◽  
Myounggyu Noh
Keyword(s):  
Flexible Electronics ◽  
Inkjet Printing ◽  
Temperature Sensor ◽  
Computer Aided Design ◽  
Low Cost ◽  
Three Dimensional ◽  
Drop On Demand ◽  
Aided Design ◽  
Nanoparticle Ink ◽  
Inkjet Printhead

Abstract Recently, the three-dimensional (3D) printing technique has attracted much attention for creating objects of arbitrary shape and manufacturing. For the first time, in this work, we present the fabrication of an inkjet printed low-cost 3D temperature sensor on a 3D-shaped thermoplastic substrate suitable for packaging, flexible electronics, and other printed applications. The design, fabrication, and testing of a 3D printed temperature sensor are presented. The sensor pattern is designed using a computer-aided design program and fabricated by drop-on-demand inkjet printing using a magnetostrictive inkjet printhead at room temperature. The sensor pattern is printed using commercially available conductive silver nanoparticle ink. A moving speed of 90 mm/min is chosen to print the sensor pattern. The inkjet printed temperature sensor is demonstrated, and it is characterized by good electrical properties, exhibiting good sensitivity and linearity. The results indicate that 3D inkjet printing technology may have great potential for applications in sensor fabrication.

scholarly journals Computer Numerically Controlled Drawing Robot Based on Computer-Aided Design

2021 ◽  
Author(s):  
Antor Mahamudul Hashan ◽  
Abdullah Haidari ◽  
Srishti Saha ◽  
Titas Paul
Keyword(s):  
Open Source ◽  
Computer Aided Design ◽  
Low Cost ◽  
Rapid Development ◽  
Main Idea ◽  
Numerical Control ◽  
Computer Aided ◽  
Complex Circuits ◽  
Open Source Hardware ◽  
Aided Design

Due to the rapid development of technology, the use of numerically controlled machines in the industry is increasing. The main idea behind this paper is computer-aided design (CAD) based low-cost computer numerical control 2D drawing robot that can accurately draw complex circuits, diagrams, logos, etc. The system is created using open-source hardware and software, which makes it available at a low cost. The open-source LibreCAD application has been used for computer-aided design. Geometric data of a CAD model is converted to coordinate points using the python-based F-Engrave application. This system uses the Arduino UNO board as a signal generator of the universal g-code sender without compromising the performance. The proposed drawing robot is designed as a low-cost robot for educational purposes and aims to increase the student's interest in robotics and computer-aided design (CAD) skills to the next level. The drawing robot structure has been developed, and it meets the requirements of low cost with satisfactory experimental results.

scholarly journals Main Clinical Use of Additive Manufacturing (Three-Dimensional Printing) in Finland Restricted to the Head and Neck Area in 2016–2017

2019 ◽  
Vol 109 (2) ◽  
pp. 166-173 ◽  
Author(s):  
A.B.V. Pettersson ◽  
M. Salmi ◽  
P. Vallittu ◽  
W. Serlo ◽  
J. Tuomi ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Computer Aided Design ◽  
Three Dimensional ◽  
Patient Specific ◽  
Future Research ◽  
Imaging Data ◽  
University Hospitals ◽  
Three Dimensional Printing ◽  
Dimensional Printing ◽  
Head Area

Background and Aims: Additive manufacturing or three-dimensional printing is a novel production methodology for producing patient-specific models, medical aids, tools, and implants. However, the clinical impact of this technology is unknown. In this study, we sought to characterize the clinical adoption of medical additive manufacturing in Finland in 2016–2017. We focused on non-dental usage at university hospitals. Materials and Methods: A questionnaire containing five questions was sent by email to all operative, radiologic, and oncologic departments of all university hospitals in Finland. Respondents who reported extensive use of medical additive manufacturing were contacted with additional, personalized questions. Results: Of the 115 questionnaires sent, 58 received answers. Of the responders, 41% identified as non-users, including all general/gastrointestinal (GI) and vascular surgeons, urologists, and gynecologists; 23% identified as experimenters or previous users; and 36% identified as heavy users. Usage was concentrated around the head area by various specialties (neurosurgical, craniomaxillofacial, ear, nose and throat diseases (ENT), plastic surgery). Applications included repair of cranial vault defects and malformations, surgical oncology, trauma, and cleft palate reconstruction. Some routine usage was also reported in orthopedics. In addition to these patient-specific uses, we identified several off-the-shelf medical components that were produced by additive manufacturing, while some important patient-specific components were produced by traditional methodologies such as milling. Conclusion: During 2016–2017, medical additive manufacturing in Finland was routinely used at university hospitals for several applications in the head area. Outside of this area, usage was much less common. Future research should include all patient-specific products created by a computer-aided design/manufacture workflow from imaging data, instead of concentrating on the production methodology.

Computer-aided design and three-dimensional printing improves symmetry in heminasal reconstruction outcomes

2019 ◽  
Vol 72 (7) ◽  
pp. 1198-1206 ◽  
Author(s):  
Cheng-I Yen ◽  
Jonathan A. Zelken ◽  
Chun-Shin Chang ◽  
Lun-Jou Lo ◽  
Jui-Yung Yang ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Computer Aided ◽  
Aided Design ◽  
Dimensional Printing

Computer-aided design and three-dimensional printing in the manufacturing of an ocular prosthesis

2016 ◽  
Vol 100 (7) ◽  
pp. 879-881 ◽  
Author(s):  
Sébastien Ruiters ◽  
Yi Sun ◽  
Stéphan de Jong ◽  
Constantinus Politis ◽  
Ilse Mombaerts
Keyword(s):  
Computer Aided Design ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Ocular Prosthesis ◽  
Computer Aided ◽  
Aided Design ◽  
Dimensional Printing

scholarly journals Three-dimensional printing of a patient-specific engineered nasal cartilage for augmentative rhinoplasty

2019 ◽  
Vol 10 ◽  
pp. 204173141882479 ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Yeong-Jin Choi ◽  
Jin Woo Jung ◽  
Jinah Jang ◽  
Tae-Ha Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Computer Aided Design ◽  
Three Dimensional ◽  
Patient Specific ◽  
Adipose Derived Stem Cells ◽  
Three Dimensional Printing ◽  
Nasal Cartilage ◽  
Computer Aided ◽  
Aided Design ◽  
Dimensional Printing

Autologous cartilages or synthetic nasal implants have been utilized in augmentative rhinoplasty to reconstruct the nasal shape for therapeutic and cosmetic purposes. Autologous cartilage is considered to be an ideal graft, but has drawbacks, such as limited cartilage source, requirements of additional surgery for obtaining autologous cartilage, and donor site morbidity. In contrast, synthetic nasal implants are abundantly available but have low biocompatibility than the autologous cartilages. Moreover, the currently used nasal cartilage grafts involve additional reshaping processes, by meticulous manual carving during surgery to fit the diverse nose shape of each patient. The final shapes of the manually tailored implants are highly dependent on the surgeons’ proficiency and often result in patient dissatisfaction and even undesired separation of the implant. This study describes a new process of rhinoplasty, which integrates three-dimensional printing and tissue engineering approaches. We established a serial procedure based on computer-aided design to generate a three-dimensional model of customized nasal implant, and the model was fabricated through three-dimensional printing. An engineered nasal cartilage implant was generated by injecting cartilage-derived hydrogel containing human adipose-derived stem cells into the implant containing the octahedral interior architecture. We observed remarkable expression levels of chondrogenic markers from the human adipose-derived stem cells grown in the engineered nasal cartilage with the cartilage-derived hydrogel. In addition, the engineered nasal cartilage, which was implanted into mouse subcutaneous region, exhibited maintenance of the exquisite shape and structure, and striking formation of the cartilaginous tissues for 12 weeks. We expect that the developed process, which combines computer-aided design, three-dimensional printing, and tissue-derived hydrogel, would be beneficial in generating implants of other types of tissue.

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