scholarly journals Acoustic tweezer with complex boundary-free trapping and transport channel controlled by shadow waveguides

2021 ◽  
Vol 7 (34) ◽  
pp. eabi5502
Author(s):  
Junfei Li ◽  
Chen Shen ◽  
Tony Jun Huang ◽  
Steven A. Cummer
Keyword(s):  
Single Pair ◽  
Particle Manipulation ◽  
Particle Trapping ◽  
Transport Channel ◽  
Complex Particle ◽  
Input Signals ◽  
Wave Patterns ◽  
Complex Boundary ◽  
Acoustic Tweezers ◽  
Contact Free

Acoustic tweezers use ultrasound for contact-free, bio-compatible, and precise manipulation of particles from millimeter to submicrometer scale. In microfluidics, acoustic tweezers typically use an array of sources to create standing wave patterns that can trap and move objects in ways constrained by the limited complexity of the acoustic wave field. Here, we demonstrate spatially complex particle trapping and manipulation inside a boundary-free chamber using a single pair of sources and an engineered structure outside the chamber that we call a shadow waveguide. The shadow waveguide creates a tightly confined, spatially complex acoustic field inside the chamber without requiring any interior structure that would interfere with net flow or transport. Altering the input signals to the two sources creates trapped particle motion along an arbitrary path defined by the shadow waveguide. Particle trapping, particle manipulation and transport, and Thouless pumping are experimentally demonstrated.

scholarly journals Micro-particle manipulation by single beam acoustic tweezers based on hydrothermal PZT thick film

AIP Advances ◽  
2016 ◽  
Vol 6 (3) ◽  
pp. 035102 ◽  
Author(s):  
Benpeng Zhu ◽  
Jiong Xu ◽  
Ying Li ◽  
Tian Wang ◽  
Ke Xiong ◽  
...  
Keyword(s):  
Thick Film ◽  
Particle Manipulation ◽  
Single Beam ◽  
Acoustic Tweezers ◽  
Pzt Thick Film

scholarly journals Three dimensional acoustic tweezers with vortex streaming

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Junfei Li ◽  
Alexandru Crivoi ◽  
Xiuyuan Peng ◽  
Lu Shen ◽  
Yunjiao Pu ◽  
...  
Keyword(s):  
Acoustic Streaming ◽  
Three Dimensional ◽  
Radiation Force ◽  
Two Dimensions ◽  
Single Beam ◽  
Scale Particle ◽  
Acoustic Tweezers ◽  
Third Dimension ◽  
Contact Free ◽  
Micrometer Scale

AbstractAcoustic tweezers use ultrasound for contact-free manipulation of particles from millimeter to sub-micrometer scale. Particle trapping is usually associated with either radiation forces or acoustic streaming fields. Acoustic tweezers based on single-beam focused acoustic vortices have attracted considerable attention due to their selective trapping capability, but have proven difficult to use for three-dimensional (3D) trapping without a complex transducer array and significant constraints on the trapped particle properties. Here we demonstrate a 3D acoustic tweezer in fluids that uses a single transducer and combines the radiation force for trapping in two dimensions with the streaming force to provide levitation in the third dimension. The idea is demonstrated in both simulation and experiments operating at 500 kHz, and the achieved levitation force reaches three orders of magnitude larger than for previous 3D trapping. This hybrid acoustic tweezer that integrates acoustic streaming adds an additional twist to the approach and expands the range of particles that can be manipulated.

scholarly journals Three dimensional acoustic tweezers with acoustic vortex streaming

2021 ◽  
Author(s):  
Junfei Li ◽  
Alexandru Crivoi ◽  
Xiuyuan Peng ◽  
Lu Shen ◽  
Yunjiao Pu ◽  
...  
Keyword(s):  
Acoustic Streaming ◽  
Three Dimensional ◽  
Radiation Force ◽  
Two Dimensions ◽  
Single Beam ◽  
Scale Particle ◽  
Acoustic Tweezers ◽  
Third Dimension ◽  
Contact Free ◽  
Micrometer Scale

Abstract Acoustic tweezers use ultrasound for contact-free manipulation of particles from millimeter to sub-micrometer scale. Particle trapping originated in either radiation forces or acoustic streaming fields. Acoustic tweezers based on single-beam focused acoustic vortices have attracted considerable attention due to their selective trapping capability, but have proven difficult to use for 3D trapping without a complex transducer array and significant constraints on the trapped particle properties. Here we demonstrate the first 3D acoustic tweezer that uses a single transducer and combines the radiation force for trapping in two dimensions with the streaming force to provide levitation in the third dimension. The idea is demonstrated in both simulation and experiments, and the achieved levitation force reaches three orders of magnitude larger than for previous 3D trapping. This hybrid acoustic tweezer that integrates acoustic streaming adds a new twist to the approach and expands the range of particles that can be manipulated.

scholarly journals Self-Navigated 3D Acoustic Tweezers in Complex Media Based on Time Reversal

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Ye Yang ◽  
Teng Ma ◽  
Sinan Li ◽  
Qi Zhang ◽  
Jiqing Huang ◽  
...  
Keyword(s):  
Time Reversal ◽  
Acoustic Waves ◽  
Heterogeneous Media ◽  
Ex Vivo ◽  
Particle Manipulation ◽  
Practical Applications ◽  
Wide Range ◽  
Acoustic Tweezers ◽  
Human Skulls ◽  
Ultrasonic Images

Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media. However, the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation. In this study, we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images, thereby enabling acoustic manipulation in nontransparent media. Furthermore, we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps. We achieved 3D particle manipulation in heterogeneous media (through resin baffle and ex vivo macaque and human skulls) by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves. Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery, controlled micromachine transfer, and precise treatment.

scholarly journals Three-dimensional manipulation of single cells using surface acoustic waves

2016 ◽  
Vol 113 (6) ◽  
pp. 1522-1527 ◽  
Author(s):  
Feng Guo ◽  
Zhangming Mao ◽  
Yuchao Chen ◽  
Zhiwei Xie ◽  
James P. Lata ◽  
...  
Keyword(s):  
Acoustic Waves ◽  
Single Cells ◽  
Surface Acoustic Waves ◽  
Three Dimensional ◽  
Biological Cells ◽  
Acoustic Vibrations ◽  
Label Free ◽  
Acoustic Tweezers ◽  
Contact Free ◽  
Micrometer Scale

The ability of surface acoustic waves to trap and manipulate micrometer-scale particles and biological cells has led to many applications involving “acoustic tweezers” in biology, chemistry, engineering, and medicine. Here, we present 3D acoustic tweezers, which use surface acoustic waves to create 3D trapping nodes for the capture and manipulation of microparticles and cells along three mutually orthogonal axes. In this method, we use standing-wave phase shifts to move particles or cells in-plane, whereas the amplitude of acoustic vibrations is used to control particle motion along an orthogonal plane. We demonstrate, through controlled experiments guided by simulations, how acoustic vibrations result in micromanipulations in a microfluidic chamber by invoking physical principles that underlie the formation and regulation of complex, volumetric trapping nodes of particles and biological cells. We further show how 3D acoustic tweezers can be used to pick up, translate, and print single cells and cell assemblies to create 2D and 3D structures in a precise, noninvasive, label-free, and contact-free manner.

scholarly journals Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices

2021 ◽  
Vol 7 (2) ◽  
pp. eabc7885
Author(s):  
Haodong Zhu ◽  
Peiran Zhang ◽  
Zhanwei Zhong ◽  
Jianping Xia ◽  
Joseph Rich ◽  
...  
Keyword(s):  
Acoustic Radiation ◽  
Acoustic Streaming ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Spatial Arrangement ◽  
Label Free ◽  
Droplet Transport ◽  
Dimensional Boundary ◽  
Acoustic Tweezers ◽  
Contact Free

Acoustics-based tweezers provide a unique toolset for contactless, label-free, and precise manipulation of bioparticles and bioanalytes. Most acoustic tweezers rely on acoustic radiation forces; however, the accompanying acoustic streaming often generates unpredictable effects due to its nonlinear nature and high sensitivity to the three-dimensional boundary conditions. Here, we demonstrate acoustohydrodynamic tweezers, which generate stable, symmetric pairs of vortices to create hydrodynamic traps for object manipulation. These stable vortices enable predictable control of a flow field, which translates into controlled motion of droplets or particles on the operating surface. We built a programmable droplet-handling platform to demonstrate the basic functions of planar-omnidirectional droplet transport, merging droplets, and in situ mixing via a sequential cascade of biochemical reactions. Our acoustohydrodynamic tweezers enables improved control of acoustic streaming and demonstrates a previously unidentified method for contact-free manipulation of bioanalytes and digitalized liquid handling based on a compact and scalable functional unit.

scholarly journals Ultrasonic Particle Manipulation in Glass Capillaries: A Concise Review

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 876
Author(s):  
Guotian Liu ◽  
Junjun Lei ◽  
Feng Cheng ◽  
Kemin Li ◽  
Xuanrong Ji ◽  
...  
Keyword(s):  
Cross Sections ◽  
Ultrasonic Waves ◽  
Submicron Particles ◽  
Label Free ◽  
Particle Manipulation ◽  
Glass Capillary ◽  
Ultrasonic Particle Manipulation ◽  
Glass Capillaries ◽  
Acoustic Tweezers ◽  
Underlying Mechanisms

Ultrasonic particle manipulation (UPM), a non-contact and label-free method that uses ultrasonic waves to manipulate micro- or nano-scale particles, has recently gained significant attention in the microfluidics community. Moreover, glass is optically transparent and has dimensional stability, distinct acoustic impedance to water and a high acoustic quality factor, making it an excellent material for constructing chambers for ultrasonic resonators. Over the past several decades, glass capillaries are increasingly designed for a variety of UPMs, e.g., patterning, focusing, trapping and transporting of micron or submicron particles. Herein, we review established and emerging glass capillary-transducer devices, describing their underlying mechanisms of operation, with special emphasis on the application of glass capillaries with fluid channels of various cross-sections (i.e., rectangular, square and circular) on UPM. We believe that this review will provide a superior guidance for the design of glass capillary-based UPM devices for acoustic tweezers-based research.

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