scholarly journals CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding

Science ◽  
2015 ◽  
Vol 349 (6243) ◽  
pp. 91-95 ◽  
Author(s):  
Hsiu-Chuan Lin ◽  
Szu-Chi Ho ◽  
Yi-Yun Chen ◽  
Kay-Hooi Khoo ◽  
Pang-Hung Hsu ◽  
...  
Keyword(s):  
Quality Control ◽  
Control System ◽  
Protein Degradation ◽  
Genetic Code ◽  
Ubiquitin Ligase ◽  
Protein Quality ◽  
Translation Termination ◽  
Protein Quality Control ◽  
Selenium Intake ◽  
Protein Quality Control System

Selenocysteine (Sec) is translated from the codon UGA, typically a termination signal. Codon duality extends the genetic code; however, the coexistence of two competing UGA-decoding mechanisms immediately compromises proteome fidelity. Selenium availability tunes the reassignment of UGA to Sec. We report a CRL2 ubiquitin ligase–mediated protein quality-control system that specifically eliminates truncated proteins that result from reassignment failures. Exposing the peptide immediately N-terminal to Sec, a CRL2 recognition degron, promotes protein degradation. Sec incorporation destroys the degron, protecting read-through proteins from detection by CRL2. Our findings reveal a coupling between directed translation termination and proteolysis-assisted protein quality control, as well as a cellular strategy to cope with fluctuations in organismal selenium intake.

scholarly journals A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases

2020 ◽  
Vol 12 ◽  
Author(s):  
Riccardo Cristofani ◽  
Valeria Crippa ◽  
Maria Elena Cicardi ◽  
Barbara Tedesco ◽  
Veronica Ferrari ◽  
...  
Keyword(s):  
Quality Control ◽  
Control System ◽  
Motor Neuron ◽  
Crucial Role ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Quality Control System ◽  
Motor Neuron Diseases ◽  
Protein Quality Control System

scholarly journals Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease

2021 ◽  
Vol 23 (1) ◽  
pp. 345
Author(s):  
Yaping Liu ◽  
Runrong Ding ◽  
Ze Xu ◽  
Yuan Xue ◽  
Dongdong Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quality Control ◽  
Control System ◽  
Protein Quality ◽  
Early Stage ◽  
Senile Plaques ◽  
Protein Quality Control ◽  
Quality Control System ◽  
Protein Quality Control System

Alzheimer’s disease (AD) is characterized by the deposition of senile plaques (SPs) and the formation of neurofibrillary tangles (NTFs), as well as neuronal dysfunctions in the brain, but in fact, patients have shown a sustained disease progression for at least 10 to 15 years before these pathologic biomarkers can be detected. Consequently, as the most common chronic neurological disease in the elderly, the challenge of AD treatment is that it is short of effective biomarkers for early diagnosis. The protein quality control system is a collection of cellular pathways that can recognize damaged proteins and thereby modulate their turnover. Abundant evidence indicates that the accumulation of abnormal proteins in AD is closely related to the dysfunction of the protein quality control system. In particular, it is the synthesis, degradation, and removal of essential biological components that have already changed in the early stage of AD, which further encourages us to pay more attention to the protein quality control system. The review mainly focuses on the endoplasmic reticulum system (ERS), autophagy–lysosome system (ALS) and the ubiquitin–proteasome system (UPS), and deeply discusses the relationship between the protein quality control system and the abnormal proteins of AD, which can not only help us to understand how and why the complex regulatory system becomes malfunctional during AD progression, but also provide more novel therapeutic strategies to prevent the development of AD.

Components of the protein quality control system are expressed in a strain-dependent manner in the mouse hippocampus

2006 ◽  
Vol 49 (5) ◽  
pp. 500-507 ◽  
Author(s):  
Daniela D. Pollak ◽  
Julius John ◽  
Hermann Bubna-Littitz ◽  
Angela Schneider ◽  
Harald Hoeger ◽  
...  
Keyword(s):  
Quality Control ◽  
Control System ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Quality Control System ◽  
Dependent Manner ◽  
Mouse Hippocampus ◽  
Protein Quality Control System ◽  
Strain Dependent
Sign in / Sign up

Export Citation Format

Share Document