Oh, the places you’ll go!

2018 ◽  
Vol 10 (425) ◽  
pp. eaar7522
Author(s):  
Jennifer A. Philips
Keyword(s):  
Stem Cells ◽  
Amyloid Plaques ◽  
Selection Strategy ◽  
In Vivo Selection ◽  
Β Amyloid ◽  
The Brain

An in vivo selection strategy identifies an antibody that induces stem cells to differentiate into microglia-like cells, migrate to the brain, and reduce β-amyloid plaques in mice.

Novel quinoxaline derivatives for in vivo imaging of β-amyloid plaques in the brain

2011 ◽  
Vol 21 (14) ◽  
pp. 4193-4196 ◽  
Author(s):  
Mengchao Cui ◽  
Masahiro Ono ◽  
Hiroyuki Kimura ◽  
Boli Liu ◽  
Hideo Saji
Keyword(s):  
In Vivo Imaging ◽  
Amyloid Plaques ◽  
Quinoxaline Derivatives ◽  
Β Amyloid ◽  
The Brain

Recent advances in molecular imaging probes for β-amyloid plaques

MedChemComm ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 391-402 ◽  
Author(s):  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Molecular Imaging ◽  
Optical Imaging ◽  
Amyloid Plaques ◽  
Recent Advances ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Β Amyloid ◽  
The Brain

We review recent advances in our development of molecular imaging probes for PET, SPECT, and optical imaging for in vivo detection of β-amyloid plaques in the brain.

Radioiodinated Flavones for in Vivo Imaging of β-Amyloid Plaques in the Brain

2005 ◽  
Vol 48 (23) ◽  
pp. 7253-7260 ◽  
Author(s):  
Masahiro Ono ◽  
Naoko Yoshida ◽  
Kenichi Ishibashi ◽  
Mamoru Haratake ◽  
Yasushi Arano ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Amyloid Plaques ◽  
Β Amyloid ◽  
The Brain

ChemInform Abstract: Novel Quinoxaline Derivatives for in vivo Imaging of β-Amyloid Plaques in the Brain.

ChemInform ◽  
2011 ◽  
Vol 42 (48) ◽  
pp. no-no
Author(s):  
Mengchao Cui ◽  
Masahiro Ono ◽  
Hiroyuki Kimura ◽  
Boli Liu ◽  
Hideo Saji
Keyword(s):  
In Vivo Imaging ◽  
Amyloid Plaques ◽  
Quinoxaline Derivatives ◽  
Β Amyloid ◽  
The Brain

In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

2015 ◽  
Vol 51 (96) ◽  
pp. 17124-17127 ◽  
Author(s):  
Hiroyuki Watanabe ◽  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Fluorescence Imaging ◽  
Amyloid Plaques ◽  
Fluorescent Imaging ◽  
Imaging Probe ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Β Amyloid ◽  
The Brain

We report a newin vivofluorescent imaging probe, DTM-2, that can detect β-amyloid plaques in the brain.

scholarly journals SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Brain Tissue ◽  
Quantitative Evaluation ◽  
Amyloid Plaques ◽  
Current Situation ◽  
Definitive Diagnosis ◽  
Spect Imaging ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Brain

The development of radiotracers for use in vivo to image β-amyloid (Aβ) plaques in cases of Alzheimer's disease (AD) is an important, active area of research. The presence of Aβ aggregates in the brain is generally accepted as a hallmark of AD. Since the only definitive diagnosis of AD is by postmortem staining of affected brain tissue, the development of techniques which enable one to image Aβ plaques in vivo has been strongly desired. Furthermore, the quantitative evaluation of Aβ plaques in the brain could facilitate evaluation of the efficacy of antiamyloid therapies currently under development. This paper reviews the current situation in the development of agents for SPECT-based imaging of Aβ plaques in Alzheimer's brains.

scholarly journals Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

2015 ◽  
Vol 44 (7) ◽  
pp. 1807-1819 ◽  
Author(s):  
Matteo Staderini ◽  
María Antonia Martín ◽  
Maria Laura Bolognesi ◽  
J. Carlos Menéndez
Keyword(s):  
Near Infrared ◽  
Amyloid Plaques ◽  
Fluorescent Tracers ◽  
Non Invasive ◽  
Nir Imaging ◽  
New Frontier ◽  
Invasive Method ◽  
Β Amyloid

Near infrared (NIR) imaging is a promising and non-invasive method to visualize amyloid plaquesin vivo.

Antibodies to β-Amyloid Decrease the Blood-to-Brain Transfer of β-Amyloid Peptide1

2002 ◽  
Vol 227 (8) ◽  
pp. 609-615 ◽  
Author(s):  
Weihong Pan ◽  
Beka Solomon ◽  
Lawrence M. Maness ◽  
Abba J. Kastin
Keyword(s):  
Ex Vivo ◽  
Amyloid Β ◽  
Brain Perfusion ◽  
Brain Parenchyma ◽  
Amyloid Angiopathy ◽  
Β Amyloid ◽  
Blocking Antibodies ◽  
The Brain

Amyloid-β peptides (Aβ) play an important role in the pathophysiology of dementia of the Alzheimer's type and in amyloid angiopathy. Aβ outside the CNS could contribute to plaque formation in the brain where its entry would involve interactions with the blood-brain barrier (BBB). Effective antibodies to Aβ have been developed in an effort to vaccinate against Alzheimer's disease. These antibodies could interact with Aβ in the peripheral blood, block the passage of Aβ across the BBB, or prevent Aβ deposition within the CNS. To determine whether the blocking antibodies act at the BBB level, we examined the influx of radiolabeled Aβ (125I-Aβ1-40) into the brain after ex-vivo incubation with the antibodies. Antibody mAb3D6 (élan Company) reduced the blood-to-brain influx of Aβ after iv bolus injection. It also significantly decreased the accumulation of Aβ in brain parenchyma. To confirm the in-vivo study and examine the specificity of mAb3D6, in-situ brain perfusion in serum-free buffer was performed after incubation of 125I-Aβ1-40 with another antibody mAbmc1 (DAKO Company). The presence of mAbmc1 also caused significant reduction of the influx of Aβ into the brain after perfusion. Therefore, effective antibodies to Aβ can reduce the influx of Aβ1-40 into the brain.

A Novel Imaging Probe for In Vivo Detection of Neuritic and Diffuse Amyloid Plaques in the Brain

2004 ◽  
Vol 24 (2) ◽  
pp. 247-256 ◽  
Author(s):  
Nobuyuki Okamura ◽  
Takahiro Suemoto ◽  
Tsuyoshi Shiomitsu ◽  
Masako Suzuki ◽  
Hiroshi Shimadzu ◽  
...  
Keyword(s):  
Amyloid Plaques ◽  
Imaging Probe ◽  
In Vivo Detection ◽  
The Brain
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