Efficacy of Humanized High-Dose Meropenem, Cefepime, and Levofloxacin against Enterobacteriaceae Isolates Producing Verona Integron-Encoded Metallo-β-Lactamase (VIM) in a Murine Thigh Infection Model
2015 ◽
Vol 59
(11)
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pp. 7145-7147
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ABSTRACTWe aimed to describe thein vivoactivity of humanized pharmacokinetic exposures of meropenem and comparators against Verona integron-encoded metallo-β-lactamase (MBL) (VIM)-producingEnterobacteriaceaein a murine model. Levofloxacin activity was predicted by its MIC, and cefepime activity displayed variability, whereas meropenem produced a >1 log CFU reduction against all isolates despite high MICs indicative of resistance. Our results suggest that despitein vitroresistance, high-dose meropenem may be a possible option against infections caused byEnterobacteriaceaeproducing MBL-type carbapenemases.
2013 ◽
Vol 58
(3)
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pp. 1671-1677
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2013 ◽
Vol 57
(8)
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pp. 3936-3940
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2014 ◽
Vol 58
(11)
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pp. 7007-7009
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2015 ◽
Vol 59
(4)
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pp. 2113-2121
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2015 ◽
Vol 59
(6)
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pp. 3645-3647
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