UnexpectedIn VivoActivity of Ceftazidime Alone and in Combination with Avibactam against New Delhi Metallo-β-Lactamase-Producing Enterobacteriaceae in a Murine Thigh Infection Model
2014 ◽
Vol 58
(11)
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pp. 7007-7009
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ABSTRACTThe emergence of the New Delhi metallo-β-lactamase (NDM) amongEnterobacteriaceaehas become a global concern because of its high levels ofin vitroresistance to nearly all available antibiotics. However, recentin vivostudies demonstrated the efficacies of carbapenems against NDM-1-producing isolates despite high MICs. Herein, we reportin vivofindings with ceftazidime and ceftazidime-avibactam against an isogenic pair (wild type and NDM-1) and four clinical NDM-producing isolates that demonstrate discordance between MICs measuredin vitroand thein vivoactivity of ceftazidime-avibactam against this resistant genotype.
2013 ◽
Vol 57
(8)
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pp. 3936-3940
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2013 ◽
Vol 58
(3)
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pp. 1671-1677
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2015 ◽
Vol 59
(11)
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pp. 7145-7147
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2015 ◽
Vol 59
(4)
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pp. 2113-2121
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