A Novel FexA Variant from a Canine Staphylococcus pseudintermedius Isolate That Does Not Confer Florfenicol Resistance
2013 ◽
Vol 57
(11)
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pp. 5763-5766
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Keyword(s):
ABSTRACTTransposon Tn558integrated in the chromosomalradCgene was detected for the first time inStaphylococus pseudintermedius. It carried a novelfexAvariant (fexAv) that confers only chloramphenicol resistance. The exporter FexAv exhibited two amino acid substitutions, Gly33Ala and Ala37Val, both of which seem to be important for substrate recognition. Site-directed mutagenesis that reverted the mutated base pairs to those present in the originalfexAgene restored the chloramphenicol-plus-florfenicol resistance phenotype.
1995 ◽
Vol 230
(3)
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pp. 958-964
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2002 ◽
Vol 46
(9)
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pp. 3035-3038
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2016 ◽
Vol 60
(6)
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pp. 3709-3716
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2009 ◽
Vol 54
(1)
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pp. 471-476
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2016 ◽
Vol 60
(4)
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pp. 2248-2256
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2021 ◽