Rifampin, Rifapentine, and Rifabutin are Active Against Intracellular Periprosthetic Joint Infection-Associated Staphylococcus epidermidis
Keyword(s):
Staphylococcus epidermidis is a major cause of periprosthetic joint infection (PJI); its intracellular persistence within osteoblasts may compromise therapy if that therapy is not intracellularly active. The intracellular activity of rifampin, rifapentine, and rifabutin was assessed against five rifampin-susceptible and two rifampin-resistant S. epidermidis isolates. Compared to no treatment, treatment resulted in a ≥2-fold log10 reduction of intracellular rifampin-susceptible, but not rifampin-resistant S. epidermidis. These findings show activity of rifampin, rifapentine, and rifabutin against intra-osteoblast PJI-associated S. epidermidis.
2020 ◽
Vol 13
(3)
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pp. 241-247
2019 ◽
Vol 93
(2)
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pp. 125-130
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2014 ◽
Vol 24
(2-3)
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pp. 89-97
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