Activity of Omadacycline in Rat Methicillin-Resistant
Staphylococcus aureus
Osteomyelitis
Keyword(s):
Omadacycline, vancomycin and rifampin as well as rifampin combination therapies were evaluated in an experimental rat model of MRSA osteomyelitis. All treatment groups had less MRSA recovered than saline-treated animals. Emergence of rifampin resistance was observed in 3 of 16 animals with rifampin monotherapy, and none with rifampin combination therapy. After treatment, the median tibial bacterial load was 6.04, 0.1, 4.81 and 5.24 log 10 cfu/g for saline-, rifampin-, vancomycin- and omadacycline-treated animals. Omadacycline or vancomycin administered with rifampin yielded no detectable MRSA. Omadacycline, administered with rifampin, deserves evaluation in humans as a potential treatment for osteomyelitis.
2010 ◽
Vol 55
(3)
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pp. 1182-1186
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Keyword(s):
2017 ◽
Vol 39
(1)
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pp. 212-218
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2019 ◽
Vol 6
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pp. 204993611988650
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2014 ◽
Vol 58
(9)
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pp. 5111-5116
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2012 ◽
Vol 56
(5)
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pp. 2342-2346
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2013 ◽
Vol 209
(9)
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pp. 1469-1478
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2021 ◽
Vol 8
(Supplement_1)
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pp. S209-S210