Tigecycline DisplaysIn VivoBactericidal Activity against Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae after 72-Hour Exposure Period
2012 ◽
Vol 57
(1)
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pp. 640-642
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Keyword(s):
ABSTRACTProgressively enhanced activity of a humanized tigecycline (TGC) regimen was noted over 3 days against an extended-spectrum-β-lactamase (ESBL)-producingEscherichia coliisolate and an ESBL-producingKlebsiella pneumoniaeisolate. Bacterial density reduction approximated 3 log10approaching bactericidal activity at 72 h. This level of activity has not been previously noted for compounds such as tetracyclines, normally considered bacteriostatic antimicrobials. Extended regimen studiesin vivomay aid in better delineation of antimicrobial effects, producing improved correlation with clinical outcomes.
2007 ◽
Vol 51
(4)
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pp. 1481-1486
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Keyword(s):
2019 ◽
Vol 53
(4)
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pp. 423-428
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2012 ◽
Vol 56
(6)
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pp. 2888-2893
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2012 ◽
Vol 56
(8)
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pp. 4516-4518
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2012 ◽
Vol 79
(3)
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pp. 1052-1054
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Keyword(s):
2016 ◽
Vol 60
(5)
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pp. 3001-3006
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2012 ◽
Vol 56
(5)
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pp. 2759-2760
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Keyword(s):