In Vitro
Antibacterial Activity of Cefiderocol against Multidrug-Resistant
Acinetobacter baumannii
Keyword(s):
Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC minimum inhibitory concentration (MIC) values than the comparator Gram-negative agents (87% of MICs ≤ 4mg/L). Six isolates, with elevated CFDC MICs (16-32 mg/L), were selected for further experiments. Time-kill analyses presented with synergistic activity and beta-lactamase inhibitors increased CFDC susceptibility in each of the isolates.
1999 ◽
Vol 10
(2)
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pp. 122-127
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2009 ◽
Vol 53
(6)
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pp. 2693-2695
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2015 ◽
Vol 59
(4)
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pp. 2280-2285
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2019 ◽
Vol 6
(Supplement_2)
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pp. S314-S314
2014 ◽
Vol 2
(1)
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pp. 1
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2016 ◽
Vol 60
(5)
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pp. 2671-2679
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