Adaptation of the [3H]Hypoxanthine Uptake Assay forIn Vitro-Cultured Plasmodium knowlesi Malaria Parasites
2016 ◽
Vol 60
(7)
◽
pp. 4361-4363
◽
Keyword(s):
ABSTRACTThe zoonotic malaria parasitePlasmodium knowlesihas recently been established in continuousin vitroculture. Here, thePlasmodium falciparum[3H]hypoxanthine uptake assay was adapted forP. knowlesiand used to determine the sensitivity of this parasite to chloroquine, cycloguanil, and clindamycin. The data demonstrate thatP. knowlesiis sensitive to all drugs, with 50% inhibitory concentrations (IC50s) consistent with those obtained withP. falciparum. This assay provides a platform to useP. knowlesi in vitrofor drug discovery.
2002 ◽
Vol 97
(6)
◽
pp. 901-903
◽
Keyword(s):
1983 ◽
Vol 71
(3)
◽
pp. 780-782
◽
2013 ◽
Vol 57
(6)
◽
pp. 2874-2877
◽
Keyword(s):
2006 ◽
Vol 50
(10)
◽
pp. 3343-3349
◽
2009 ◽
Vol 42
(2)
◽
pp. 103-106
◽
Keyword(s):
2014 ◽
Vol 58
(12)
◽
pp. 7398-7404
◽
Keyword(s):
Keyword(s):