Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites
2015 ◽
Vol 59
(5)
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pp. 2890-2892
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ABSTRACTA nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistantPlasmodium falciparumK-1 strain, with a significant decrease in the mean ± standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 ± 95 nM to 14 ± 2 nM, was achievedin vitroby the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB). The CQ resistance-reversing activity of 2-APB, which showed the same efficacy as verapamil, was also observed in anin vivomouse infection model with the CQ-resistantPlasmodium chabaudiAS(30CQ) strain.
2012 ◽
Vol 56
(8)
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pp. 4403-4407
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2018 ◽
Vol 62
(4)
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pp. e01732-17
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2015 ◽
Vol 59
(4)
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pp. 2113-2121
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Keyword(s):
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2013 ◽
Vol 58
(3)
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pp. 1671-1677
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