scholarly journals A Rapid Method for Screening Large Numbers of Environmental Microorganisms for Antiviral Activity

1998 ◽  
Vol 64 (3) ◽  
pp. 1161-1162 ◽  
Author(s):  
Carlo Maullu ◽  
Giorgio Lampis ◽  
Delia Deidda ◽  
Sabrina Petruzzelli ◽  
Raffaello Pompei
Keyword(s):  
Antiviral Activity ◽  
Infected Cell ◽  
Rapid Method ◽  
Close Contact ◽  
New Method ◽  
Virus Infected Cell ◽  
Cell Monolayers ◽  
Large Numbers

ABSTRACT A new method for screening microbial colonies endowed with antiviral activity is described. It is based on close contact between microbial agar cultures and agar-covered virus-infected-cell monolayers and allows the screening of large numbers of colonies in just a few months.

Selective Sampling and Orientation of Non-Homogeneous Tissues

1968 ◽  
Vol 26 ◽  
pp. 98-99
Author(s):  
C. C. Clawson ◽  
L. W. Anderson ◽  
R. A. Good
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Light Microscopy ◽  
Random Sampling ◽  
New Method ◽  
Microscope Examination ◽  
Small Areas ◽  
Selective Sampling ◽  
Large Numbers ◽  
Specific Orientation

Investigations which require electron microscope examination of a few specific areas of non-homogeneous tissues make random sampling of small blocks an inefficient and unrewarding procedure. Therefore, several investigators have devised methods which allow obtaining sample blocks for electron microscopy from region of tissue previously identified by light microscopy of present here techniques which make possible: 1) sampling tissue for electron microscopy from selected areas previously identified by light microscopy of relatively large pieces of tissue; 2) dehydration and embedding large numbers of individually identified blocks while keeping each one separate; 3) a new method of maintaining specific orientation of blocks during embedding; 4) special light microscopic staining or fluorescent procedures and electron microscopy on immediately adjacent small areas of tissue.

scholarly journals ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus–Infected Cell Autophagic Death and Represses Tumor Growth

2017 ◽  
Vol 16 (12) ◽  
pp. 2724-2734 ◽  
Author(s):  
Lu Dai ◽  
Aiping Bai ◽  
Charles D. Smith ◽  
Paulo C. Rodriguez ◽  
Fangyou Yu ◽  
...  
Keyword(s):  
Infected Cell ◽  
Tumor Growth ◽  
Sphingosine Kinase ◽  
Oncogenic Virus ◽  
Virus Infected Cell ◽  
Sphingosine Kinase 2

A Rapid Method for Collecting Large Numbers of Intestinal Helminths

1963 ◽  
Vol 49 (6) ◽  
pp. 997 ◽  
Author(s):  
John F. McCue ◽  
Ralph E. Thorson
Keyword(s):  
Rapid Method ◽  
Intestinal Helminths ◽  
Large Numbers

scholarly journals Characterizing Highly Benefited Patients in Randomized Clinical Trials

2017 ◽  
Vol 13 (1) ◽  
Author(s):  
Vivek Charu ◽  
Paul B. Rosenberg ◽  
Lon S. Schneider ◽  
Lea T. Drye ◽  
Lisa Rein ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Controlled Trial ◽  
New Method ◽  
Usual Model ◽  
Randomized Controlled ◽  
Working Model ◽  
Large Numbers ◽  
High Benefit ◽  
Two Stages

AbstractPhysicians and patients may choose a certain treatment only if it is predicted to have a large effect for the profile of that patient. We consider randomized controlled trials in which the clinical goal is to identify as many patients as possible that can highly benefit from the treatment. This is challenging with large numbers of covariate profiles, first, because the theoretical, exact method is not feasible, and, second, because usual model-based methods typically give incorrect results. Better, more recent methods use a two-stage approach, where a first stage estimates a working model to produce a scalar predictor of the treatment effect for each covariate profile; and a second stage estimates empirically a high-benefit group based on the first-stage predictor. The problem with these methods is that each of the two stages is usually agnostic about the role of the other one in addressing the clinical goal. We propose a method that characterizes highly benefited patients by linking model estimation directly to the particular clinical goal. It is shown that the new method has the following two key properties in comparison with existing approaches: first, the meaning of the solution with regard to the clinical goal is the same, and second, the value of the solution is the best that can be achieved when using the working model as a predictor, even if that model is incorrect. In the Citalopram for Agitation in Alzheimer’s Disease (CitAD) randomized controlled trial, the new method identifies substantially larger groups of highly benefited patients, many of whom are missed by the standard method.

scholarly journals The post-mortem diagnosis of influenzal infection by fluorescent IgG, IgA and IgM antibody studies on necropsy blood

1973 ◽  
Vol 71 (1) ◽  
pp. 107-112 ◽  
Author(s):  
L. M. de Silva ◽  
M. S. Khan ◽  
G. Kampfner ◽  
J. O'H. Tobin ◽  
R. Gillett ◽  
...  
Keyword(s):  
Infected Cell ◽  
Influenza A ◽  
Post Mortem ◽  
Igg Antibody ◽  
Recent Infection ◽  
Simple Method ◽  
Specific Diagnosis ◽  
Cell Monolayers ◽  
Antibody Assays ◽  
Iga Antibody

SUMMARYNecropsy blood from cases diagnosed as dying from influenza A was examined for specific antibody in the IgG, IgA and IgM fractions and a specific diagnosis of recent infection was made if either IgM or IgA antibody and low titres of IgG antibody were found. By these criteria a diagnostic rate of 77% was found in those cases from whom no virus was isolated. The use of infected cell monolayers grown on polytetrafluoroethylene-coated slides gave a simple method of carrying out these antibody assays, and the use of necropsy blood did not require any special methods of transport of specimens to the virus laboratory.

Contractants: A New Method for the Numerical Evaluation of Determinants

1955 ◽  
Vol 59 (539) ◽  
pp. 772-773 ◽  
Author(s):  
R. H. MacMillan
Keyword(s):  
Rapid Method ◽  
Numerical Evaluation ◽  
New Method ◽  
List Type ◽  
Type Number

A new method for evaluating determinants or matrices is given; it is rather tedious to describe and awkward to prove, but is very easy to use. The chief advantages this method is believed to possess are:(i)It involves as few arithmetical manipulations as does the most rapid method of pivotal condensation currently used.(ii)It is easier than any other known method to learn and to remember.(iii)It can be adapted to routine computation, in such a way as to minimise the likelihood of error.(iv)A digital computor can readily be programmed to use it.

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