scholarly journals The Genome Sequence of Avian Pathogenic Escherichia coli Strain O1:K1:H7 Shares Strong Similarities with Human Extraintestinal Pathogenic E. coli Genomes

2007 ◽  
Vol 189 (12) ◽  
pp. 4554-4554 ◽  
Author(s):  
Timothy J. Johnson ◽  
Subhashinie Kariyawasam ◽  
Yvonne Wannemuehler ◽  
Paul Mangiamele ◽  
Sara J. Johnson ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Genome Sequence ◽  
Coli Strain ◽  
Avian Pathogenic Escherichia Coli ◽  
E Coli ◽  
Pathogenic Escherichia Coli

scholarly journals Complete Genome Sequence of the Avian-Pathogenic Escherichia coli Strain APEC O18

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Bryon A. Nicholson ◽  
Yvonne M. Wannemuehler ◽  
Catherine M. Logue ◽  
Ganwu Li ◽  
Lisa K. Nolan
Keyword(s):  
Escherichia Coli ◽  
Genome Sequence ◽  
Causative Agent ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Coli Strain ◽  
Sequence Type ◽  
Poultry Production ◽  
Avian Pathogenic Escherichia Coli ◽  
Pathogenic Escherichia Coli

Avian-pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis, a disease that affects all facets of poultry production worldwide, resulting in multimillion dollar losses annually. Here, we report the genome sequence of an APEC O18 sequence type 95 (ST95) strain associated with disease in a chicken.

scholarly journals Prevalence of Avian-Pathogenic Escherichia coli Strain O1 Genomic Islands among Extraintestinal and Commensal E. coli Isolates

2012 ◽  
Vol 194 (11) ◽  
pp. 2846-2853 ◽  
Author(s):  
T. J. Johnson ◽  
Y. Wannemuehler ◽  
S. Kariyawasam ◽  
J. R. Johnson ◽  
C. M. Logue ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Coli Strain ◽  
Genomic Islands ◽  
Avian Pathogenic Escherichia Coli ◽  
E Coli ◽  
Pathogenic Escherichia Coli

scholarly journals The Genome Sequence of Avian Pathogenic Escherichia coli Strain O1:K1:H7 Shares Strong Similarities with Human Extraintestinal Pathogenic E. coli Genomes

2007 ◽  
Vol 189 (8) ◽  
pp. 3228-3236 ◽  
Author(s):  
Timothy J. Johnson ◽  
Subhashinie Kariyawasam ◽  
Yvonne Wannemuehler ◽  
Paul Mangiamele ◽  
Sara J. Johnson ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Genomic Sequence ◽  
Epidemiological Studies ◽  
Coli Strain ◽  
Avian Pathogenic Escherichia Coli ◽  
Future Studies ◽  
E Coli ◽  
Food Borne ◽  
Pathogenic Escherichia Coli ◽  
Complete Genomic

ABSTRACT Escherichia coli strains that cause disease outside the intestine are known as extraintestinal pathogenic E. coli (ExPEC) and include human uropathogenic E. coli (UPEC) and avian pathogenic E. coli (APEC). Regardless of host of origin, ExPEC strains share many traits. It has been suggested that these commonalities may enable APEC to cause disease in humans. Here, we begin to test the hypothesis that certain APEC strains possess potential to cause human urinary tract infection through virulence genotyping of 1,000 APEC and UPEC strains, generation of the first complete genomic sequence of an APEC (APEC O1:K1:H7) strain, and comparison of this genome to all available human ExPEC genomic sequences. The genomes of APEC O1 and three human UPEC strains were found to be remarkably similar, with only 4.5% of APEC O1's genome not found in other sequenced ExPEC genomes. Also, use of multilocus sequence typing showed that some of the sequenced human ExPEC strains were more like APEC O1 than other human ExPEC strains. This work provides evidence that at least some human and avian ExPEC strains are highly similar to one another, and it supports the possibility that a food-borne link between some APEC and UPEC strains exists. Future studies are necessary to assess the ability of APEC to overcome the hurdles necessary for such a food-borne transmission, and epidemiological studies are required to confirm that such a phenomenon actually occurs.

scholarly journals Complete Genome Sequence of the Avian Pathogenic Escherichia coli Strain APEC O78

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
P. Mangiamele ◽  
B. Nicholson ◽  
Y. Wannemuehler ◽  
T. Seemann ◽  
C. M. Logue ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Coli Strain ◽  
Avian Pathogenic Escherichia Coli ◽  
Pathogenic Escherichia Coli

scholarly journals Sub-lethal Concentrations of Phytochemicals (Carvacrol and Oregano) Select for Reduced Susceptibility Mutants of Escherichia coli O23:H52

2020 ◽  
Vol 69 (1) ◽  
pp. 121-125
Author(s):  
AFNAN A. AL-MNASER ◽  
MARTIN J. WOODWARD
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Coli Strain ◽  
Whole Genome ◽  
Avian Pathogenic Escherichia Coli ◽  
Antibiotic Resistant ◽  
E Coli ◽  
Pathogenic Escherichia Coli ◽  
Survival Mechanisms

In vitro studies aimed at studying the mechanism of action of carvacrol and oregano as natural anti-bacterial agents to control multiple antibiotic-resistant avian pathogenic Escherichia coli (APEC) strain O23:H52 isolated from chicken were performed. Derivatives with increased minimum inhibitory concentrations (MIC) to the phytochemicals were selected after growing Escherichia coli (E. coli) strain O23:H52 at sub-lethal concentrations of carvacrol and oregano for a period of 60 days. Whole-genome sequencing (WGS) of two derivatives revealed a missense mutation in cadC and marR: the genes responsible for survival mechanisms and antibiotic resistance by efflux, respectively.

scholarly journals The pap Operon of Avian Pathogenic Escherichia coli Strain O1:K1 Is Located on a Novel Pathogenicity Island

2006 ◽  
Vol 74 (1) ◽  
pp. 744-749 ◽  
Author(s):  
Subhashinie Kariyawasam ◽  
Timothy J. Johnson ◽  
Lisa K. Nolan
Keyword(s):  
Escherichia Coli ◽  
Virulence Genes ◽  
Trna Gene ◽  
Polysialic Acid ◽  
Pathogenicity Island ◽  
Coli Strain ◽  
Avian Pathogenic Escherichia Coli ◽  
E Coli ◽  
Pathogenic Escherichia Coli ◽  
Pap Operon

ABSTRACT We have identified a 56-kb pathogenicity island (PAI) in avian pathogenic Escherichia coli strain O1:K1 (APEC-O1). This PAI, termed PAI IAPEC-O1, is integrated adjacent to the 3′ end of the pheV tRNA gene. It carries putative virulence genes of APEC (pap operon), other E. coli genes (tia and ireA), and a 1.5-kb region unique to APEC-O1. The kps gene cluster required for the biosynthesis of polysialic acid capsule was mapped to a location immediately downstream of this PAI.

scholarly journals Complete Genome Sequence of Avian Pathogenic Escherichia coli Strain APEC O2-211

2018 ◽  
Vol 7 (12) ◽  
Author(s):  
Daniel W. Nielsen ◽  
Paul Mangiamele ◽  
Nicole Ricker ◽  
Nicolle L. Barbieri ◽  
Heather K. Allen ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Coli Strain ◽  
Sequence Type ◽  
Poultry Production ◽  
Avian Pathogenic Escherichia Coli ◽  
Content Type ◽  
Pathogenic Escherichia Coli

Avian pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis, a disease that affects poultry production worldwide and leads to multimillion-dollar losses annually. Here, we report the genome sequence of APEC O2-211, a sequence type 117 (ST117) strain isolated from a diseased chicken.

scholarly journals Complete genome sequence of multidrug-resistant avian pathogenic Escherichia coli strain APEC-O2-MS1170

2020 ◽  
Vol 23 ◽  
pp. 401-403
Author(s):  
Tianmin Li ◽  
Claudia D. Castañeda ◽  
Mark A. Arick ◽  
Chuan-Yu Hsu ◽  
Aaron S. Kiess ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Multidrug Resistant ◽  
Coli Strain ◽  
Avian Pathogenic Escherichia Coli ◽  
Pathogenic Escherichia Coli

scholarly journals Avian Pathogenic Escherichia coli (APEC): An Overview of Virulence and Pathogenesis Factors, Zoonotic Potential, and Control Strategies

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 467
Author(s):  
Dipak Kathayat ◽  
Dhanashree Lokesh ◽  
Sochina Ranjit ◽  
Gireesh Rajashekara
Keyword(s):  
Escherichia Coli ◽  
Current Status ◽  
Neonatal Meningitis ◽  
Clear Understanding ◽  
Zoonotic Potential ◽  
Secretion Systems ◽  
Avian Pathogenic Escherichia Coli ◽  
E Coli ◽  
Pathogenic Escherichia Coli ◽  
Tract Infections

Avian pathogenic Escherichia coli (APEC) causes colibacillosis in avian species, and recent reports have suggested APEC as a potential foodborne zoonotic pathogen. Herein, we discuss the virulence and pathogenesis factors of APEC, review the zoonotic potential, provide the current status of antibiotic resistance and progress in vaccine development, and summarize the alternative control measures being investigated. In addition to the known virulence factors, several other factors including quorum sensing system, secretion systems, two-component systems, transcriptional regulators, and genes associated with metabolism also contribute to APEC pathogenesis. The clear understanding of these factors will help in developing new effective treatments. The APEC isolates (particularly belonging to ST95 and ST131 or O1, O2, and O18) have genetic similarities and commonalities in virulence genes with human uropathogenic E. coli (UPEC) and neonatal meningitis E. coli (NMEC) and abilities to cause urinary tract infections and meningitis in humans. Therefore, the zoonotic potential of APEC cannot be undervalued. APEC resistance to almost all classes of antibiotics, including carbapenems, has been already reported. There is a need for an effective APEC vaccine that can provide protection against diverse APEC serotypes. Alternative therapies, especially the virulence inhibitors, can provide a novel solution with less likelihood of developing resistance.

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