scholarly journals Point-of-Care Testing for Infectious Diseases: Past, Present, and Future

2017 ◽  
Vol 55 (8) ◽  
pp. 2313-2320 ◽  
Author(s):  
Thomas R. Kozel ◽  
Amanda R. Burnham-Marusich
Keyword(s):  
Infectious Diseases ◽  
New Technologies ◽  
Point Of Care ◽  
Low Cost ◽  
Ease Of Use ◽  
Lateral Flow Immunoassay ◽  
Point Of Care Testing ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Potential Use

ABSTRACT Point-of-care (POC) diagnostics provide rapid actionable information for patient care at the time and site of an encounter with the health care system. The usual platform has been the lateral flow immunoassay. Recently, emerging molecular diagnostics have met requirements for speed, low cost, and ease of use for POC applications. A major driver for POC development is the ability to diagnose infectious diseases at sites with a limited infrastructure. The potential use in both wealthy and resource-limited settings has fueled an intense effort to build on existing technologies and to generate new technologies for the diagnosis of a broad spectrum of infectious diseases.

scholarly journals Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

2019 ◽  
Vol 11 (4) ◽  
pp. 314-315
Author(s):  
James S Leathers ◽  
Maria Belen Pisano ◽  
Viviana Re ◽  
Gertine van Oord ◽  
Amir Sultan ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Rapid Diagnosis ◽  
Direct Acting Antivirals ◽  
Resource Limited Settings ◽  
Rapid Diagnosis Test ◽  
Resource Limited ◽  
Specificity And Sensitivity ◽  
Hcv Screening ◽  
Direct Acting

Abstract Background Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. Methods We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. Results The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). Conclusions The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

The Next Phase for Point-of-Care Testing in Resource-Limited Settings

2016 ◽  
Vol 15 (2) ◽  
pp. 93-95 ◽  
Author(s):  
Lee F. Schroeder ◽  
Paul LaBarre ◽  
Bernhard Hans Weigl ◽  
Timothy Amukele
Keyword(s):  
Point Of Care ◽  
Point Of Care Testing ◽  
Resource Limited Settings ◽  
Resource Limited

Design and Validation of a Low-Cost Microscope for Diagnostics in the Developing World

2009 ◽  
Vol 17 (6) ◽  
pp. 16-19 ◽  
Author(s):  
B. Cline ◽  
R. Luo ◽  
K. Kuhlmann
Keyword(s):  
High Resolution ◽  
Infectious Diseases ◽  
Developing World ◽  
Low Cost ◽  
High Resolution Imaging ◽  
Microscope Examination ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Resolution Imaging

Many infectious diseases prevalent in the developing world, including malaria and tuberculosis, are difficult to diagnose on the basis of symptoms alone but can be accurately detected using microscope examination. Currently the expense, size, and fragility of optical microscopes impede their widespread use in resource-limited settings. Addressing these obstacles facing microscopy in the developing world is a pressing need; over 800,000 people, primarily children in Africa, die annually of malaria, and more than 1,500,000 people die annually of tuberculosis [1][2]. The aim of this study is to design and validate a microscope for use in the developing world that combines high-resolution imaging, extreme affordability, and long-term durability.

Evaluation of the blood gas analyzer GEM(r) PREMIER(tm) 3000

2004 ◽  
Vol 42 (1) ◽  
Author(s):  
Bénédicte Bénéteau-Burnat ◽  
Marie-Chantal Bocque ◽  
Anne Lorin ◽  
Catherine Martin ◽  
Michel Vaubourdolle
Keyword(s):  
New Technologies ◽  
Point Of Care ◽  
Ease Of Use ◽  
Blood Gas ◽  
Gas Analyzer ◽  
Point Of Care Testing ◽  
The Past ◽  
Miniaturized Sensors ◽  
Blood Gas Analyzer

AbstractDuring the past few decades, new technologies have allowed the fabrication of miniaturized sensors and the development of analyzers well designed for point-of-care testing (POCT). They combined the ease-of-use and portability required for POC with the accuracy and the reliability of traditional systems. Instrumentation Laboratory introduced the GEM

Low-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings

ACS Sensors ◽  
2021 ◽  
Author(s):  
Nan Jiang ◽  
Natha Dean Tansukawat ◽  
Laura Gonzalez-Macia ◽  
H. Ceren Ates ◽  
Can Dincer ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Resource Limited Settings ◽  
Resource Limited

scholarly journals Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0135869 ◽  
Author(s):  
Christopher T. Lam ◽  
Marlee S. Krieger ◽  
Jennifer E. Gallagher ◽  
Betsy Asma ◽  
Lisa C. Muasher ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Resource Limited Settings ◽  
Resource Limited

Current Point-of-Care testing in cancer and future perspectives: a systematic review

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
M Rodrigues ◽  
I Andrade ◽  
R Cruz
Keyword(s):  
Systematic Review ◽  
Early Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Rapid Test ◽  
Point Of Care Testing ◽  
Screening Programs ◽  
Low Resource ◽  
Resource Limited ◽  
Prevalent Disease

Abstract Introduction Cancer is the most prevalent disease worldwide, causing a major impact on society. Early detection and monitorization of the tumour can provide a more effective treatment. Point-of-care (POC) testing allows the patient to have a handheld test that gives the results rapidly. No expertise or special knowledge is required which is vital namely when carried out in low-resource areas. Recent studies analysed established and emerging biomarkers and how to incorporate them into POC devices, but a systematic review reporting the existing POC platforms for cancer is still not available. Objectives This systematic review aims to report current and recent advances for point-of-care testing in cancer. Methodology A literature review was conducted through research in the databases “PubMed” and “B-On” for relevant reviews published in the last ten years, using the keywords “Point-of-care testing” AND “Cancer” AND “Rapid Test” AND “Cancer detection”. Results In 2015 there were eight commercially available POC tests for prostate, bladder, colorectal, cervical, HPV-causing head and neck cancer, liver, breast and lung cancer. After 2018 a small number of POC devices were tested in screening programs and multicentric studies, and more recently, promising novel POC prototypes for early detection of cancer, namely a 3D prototype micro device for multiple singleplex RNA expression analysis in liver cancer and a POC microscopy prototype for digital diagnostics of breast cancer lymph node metastases, with potential to be used in resource-limited settings. Conclusion The use of POC testing can deliver accurate, fast results, and in the case of cancer it is no exception, contributing to the progression of treatment and reduction in cancer-related deaths. In low-resource settings a POC test is fundamental and it should be simple and low-cost. But there are limitations in the tests which is a challenge for improvement and investigation in the future.

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