Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation
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Influenza virus RNA (vRNA) promoter panhandle structures are believed to be sensed by retinoic acid-inducible gene I (RIG-I). The occurrence of mismatches in this double-stranded RNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-Iin vivo, affecting RNA/RIG-I complex formation and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.
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2016 ◽
Vol 113
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pp. 11931-11936
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2018 ◽
Vol 115
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pp. 11613-11618
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2006 ◽
Vol 8
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pp. 2013-2020
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2000 ◽
Vol 44
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pp. 200-204
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2021 ◽
2012 ◽
Vol 93
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pp. 555-559
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2015 ◽
Vol 11
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pp. 589-595
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