CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex
1991 ◽
Vol 11
(3)
◽
pp. 1248-1257
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Keyword(s):
CAP, a protein from Saccharomyces cerevisiae that copurifies with adenylyl cyclase, appears to be required for yeast cells to be fully responsive to RAS proteins. CAP also appears to be required for normal cell morphology and responsiveness to nutrient deprivation and excess. We describe here a molecular and phenotypic analysis of the CAP protein. The N-terminal domain is necessary and sufficient for cellular response to activated RAS protein, while the C-terminal domain is necessary and sufficient for normal cellular morphology and responses to nutrient extremes. Thus, CAP is a novel example of a bifunctional component involved in the regulation of diverse signal transduction pathways.
1991 ◽
Vol 11
(3)
◽
pp. 1248-1257
◽
1992 ◽
Vol 12
(11)
◽
pp. 4937-4945
1992 ◽
Vol 12
(11)
◽
pp. 4937-4945
◽
1992 ◽
Vol 12
(6)
◽
pp. 2653-2661
1987 ◽
Vol 7
(9)
◽
pp. 3268-3276
◽
1997 ◽
Vol 17
(3)
◽
pp. 1057-1064
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1987 ◽
Vol 7
(9)
◽
pp. 3268-3276
◽
2020 ◽