scholarly journals Genome Sequences of Mycobacterium tuberculosis Biovar bovis Strains Ravenel and 10-7428

2021 ◽  
Vol 10 (24) ◽  
Author(s):  
Syeda A. Hadi ◽  
Evan P. Brenner ◽  
Rinosh Mani ◽  
Mitchell V. Palmer ◽  
Tyler Thacker ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Bovine Tuberculosis ◽  
Genome Sequences ◽  
Highly Pathogenic ◽  
Content Type ◽  
Cattle Strain

We report the draft genomes of two Mycobacterium tuberculosis variant bovis strains. Strain Ravenel was isolated in the 1900s and has been shown to be attenuated in cattle. Strain 10-7428 is considered highly pathogenic in cattle and was isolated from a bovine tuberculosis outbreak.

scholarly journals Complete Genome Sequences of Three Representative Mycobacterium tuberculosis Beijing Family Strains Belonging to Distinct Genotype Clusters in Hanoi, Vietnam, during 2007 to 2009

2017 ◽  
Vol 5 (27) ◽  
Author(s):  
Takayuki Wada ◽  
Minako Hijikata ◽  
Shinji Maeda ◽  
Nguyen Thi Le Hang ◽  
Pham Huu Thuong ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Complete Genome ◽  
Population Based ◽  
Beijing Family ◽  
Genome Sequences ◽  
Population Based Study ◽  
Content Type ◽  
Asian Region ◽  
Distinct Genotype ◽  
Reference Strains

ABSTRACT We present here three complete genome sequences of Mycobacterium tuberculosis Beijing family strains isolated in Hanoi, Vietnam. These three strains were selected from major genotypic clusters (15-MIRU-VNTR) identified in a previous population-based study. We emphasize their importance and potential as reference strains in this Asian region.

scholarly journals Genome Sequences of Mycobacterium Strains Recovered from Captive Elephants with Tuberculosis

2021 ◽  
Vol 10 (36) ◽  
Author(s):  
Evan P. Brenner ◽  
Syeda A. Hadi ◽  
Beth Harris ◽  
Suelee Robbe-Austerman ◽  
Srinand Sreevatsan
Keyword(s):  
United States ◽  
Mycobacterium Tuberculosis ◽  
Endangered Species ◽  
Human Health ◽  
The United States ◽  
Whole Genome ◽  
Genome Sequences ◽  
Asian Elephants ◽  
Content Type

Members of the Mycobacterium tuberculosis complex cause tuberculosis, infamous for enormous impacts on human health. As zoonoses, they also threaten endangered species like African/Asian elephants. We report the whole-genome sequences of Mycobacterium tuberculosis biovars tuberculosis and bovis from two zoo elephants in the United States.

scholarly journals Genome Sequences of Chancellor, Mitti, and Wintermute, Three Subcluster K4 Phages Isolated Using Mycobacterium smegmatis mc2155

2017 ◽  
Vol 5 (45) ◽  
Author(s):  
Nicholas P. Edgington ◽  
Stephanie M. Voshell ◽  
Vassie C. Ware ◽  
Francis F. Akoto ◽  
Alexa A. Alhout ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Smegmatis ◽  
Genome Sequences ◽  
Content Type

ABSTRACT Mycobacteriophages Chancellor, Mitti, and Wintermute infect Mycobacterium smegmatis mc2155 and are closely related to phages Cheetobro and Fionnbharth in subcluster K4. Genome sizes range from 57,697 bp to 58,046 bp. Phages are predicted to be temperate and to infect the pathogen Mycobacterium tuberculosis.

scholarly journals Genome Sequences of Five Mycobacterium bovis Strains Isolated from Farmed Animals and Wildlife in Canada

2018 ◽  
Vol 6 (15) ◽  
pp. e00258-18
Author(s):  
Olga Andrievskaia ◽  
Marc-Olivier Duceppe ◽  
Dara Lloyd
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Mycobacterium Bovis ◽  
Causative Agent ◽  
Bovine Tuberculosis ◽  
Genome Sequences ◽  
Livestock Industry ◽  
Content Type

ABSTRACT Mycobacterium bovis is the causative agent of bovine tuberculosis, an infectious disease that affects both animals and humans and thus presents a risk to public health and the livestock industry. Here, we report the genome sequences of five Mycobacterium bovis strains that represent major genotype clusters observed in farmed animals and wildlife in Canada.

scholarly journals Draft Genome Sequences of Three Mycobacterium bovis Strains Identified in Cattle and Wildlife in France

2017 ◽  
Vol 5 (27) ◽  
Author(s):  
Maxime Branger ◽  
Amandine Hauer ◽  
Lorraine Michelet ◽  
Claudine Karoui ◽  
Thierry Cochard ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Bovis ◽  
Bovine Tuberculosis ◽  
Draft Genome ◽  
Etiologic Agent ◽  
Wild Animals ◽  
Genome Sequences ◽  
Content Type

ABSTRACT Mycobacterium bovis is the etiologic agent of bovine tuberculosis, a chronic infectious disease affecting livestock, wild animals, and sometimes humans. We report here three draft genome sequences of Mycobacterium bovis strains of spoligotypes SB0821 and SB0134, isolated from wildlife but circulating in wildlife-livestock multihost systems, and SB0121, circulating exclusively in cattle.

scholarly journals Genome Sequences of the Mycobacterium tuberculosis H37Rv-ptkA Deletion Mutant and Its Parental Strain

2017 ◽  
Vol 5 (44) ◽  
Author(s):  
Clement K. M. Tsui ◽  
Dennis Wong ◽  
Gagandeep Narula ◽  
Jennifer L. Gardy ◽  
William W. H. Hsiao ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Parental Strain ◽  
Deletion Mutant ◽  
Protein Tyrosine Kinase ◽  
Draft Genome ◽  
Genome Sequences ◽  
Genetic Studies ◽  
Content Type ◽  
Mycobacterium Tuberculosis H37rv ◽  
Strain H37rv

ABSTRACT Mycobacterium tuberculosis, the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. Here, we report the draft genome sequences of the M. tuberculosis protein tyrosine kinase (ptkA) deletion mutant and its parental strain H37Rv, which are used in genetic studies and for drug discovery.

scholarly journals Draft Genome Sequences of Local Clinical Isolates of Drug-Resistant and Drug-Sensitive Mycobacterium tuberculosis

2021 ◽  
Vol 10 (25) ◽  
Author(s):  
Norzuliana Zainal Abidin ◽  
Mohd Nur Fakhruzzaman Noorizhab ◽  
Lay Kek Teh ◽  
Wai Feng Lim ◽  
Noorliza Mohd Noordin ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Draft Genome ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Genome Plasticity ◽  
Genome Sequences ◽  
Content Type

In the battle against tuberculosis (TB), plasticity of the Mycobacterium tuberculosis genome is believed to contribute to the pathogen’s virulence and drug resistance. Here, we report 10 draft genome sequences of clinical M. tuberculosis isolated in Malaysia as the basis for understanding the genome plasticity of the M. tuberculosis isolates.

scholarly journals Whole-Genome Sequences of Mycobacterium tuberculosis TB282 and TB284, a Widespread and a Unique Strain, Respectively, Identified in a Previous Study of Tuberculosis Transmission in Central Los Angeles, California, USA

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Lixin Zhang ◽  
Zhenhua Yang
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Los Angeles ◽  
Clinical Isolates ◽  
Large Cluster ◽  
Whole Genome ◽  
Genome Sequences ◽  
Content Type ◽  
Tuberculosis Transmission ◽  
Unique Strain

ABSTRACT We report here the genome sequences of two Mycobacterium tuberculosis clinical isolates previously identified in central Los Angeles, CA, in the 1990s using a PacBio platform. Isolate TB282 represents a large-cluster strain that caused 27% of the tuberculosis cases, while TB284 represents a strain that caused disease in only one patient.

scholarly journals Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Mickael Orgeur ◽  
Wafa Frigui ◽  
Alexandre Pawlik ◽  
Simon Clark ◽  
Ann Williams ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Guinea Pig ◽  
Type Species ◽  
Clinical Isolates ◽  
Recent Common Ancestor ◽  
Genome Sequences ◽  
Content Type ◽  
Link Type ◽  
Vaccine Potential ◽  
Mycobacterium Microti

Mycobacterium microti is an animal-adapted member of the Mycobacterium tuberculosis complex (MTBC), which was originally isolated from voles, but has more recently also been isolated from other selected mammalian hosts, including occasionally from humans. Here, we have generated and analysed the complete genome sequences of five representative vole and clinical M. microti isolates using PacBio- and Illumina-based technologies, and have tested their virulence and vaccine potential in SCID (severe combined immune deficient) mouse and/or guinea pig infection models. We show that the clinical isolates studied here cluster separately in the phylogenetic tree from vole isolates and other clades from publicly available M. microti genome sequences. These data also confirm that the vole and clinical M. microti isolates were all lacking the specific RD1mic region, which in other tubercle bacilli encodes the ESX-1 type VII secretion system. Biochemical analysis further revealed marked phenotypic differences between isolates in type VII-mediated secretion of selected PE and PPE proteins, which in part were attributed to specific genetic polymorphisms. Infection experiments in the highly susceptible SCID mouse model showed that the clinical isolates were significantly more virulent than the tested vole isolates, but still much less virulent than the M. tuberculosis H37Rv control strain. The strong attenuation of the ATCC 35872 vole isolate in immunocompromised mice, even compared to the attenuated BCG (bacillus Calmette–Guérin) vaccine, and its historic use in human vaccine trials encouraged us to test this strain’s vaccine potential in a guinea pig model, where it demonstrated similar protective efficacy as a BCG control, making it a strong candidate for vaccination of immunocompromised individuals in whom BCG vaccination is contra-indicated. Overall, we provide new insights into the genomic and phenotypic variabilities and particularities of members of an understudied clade of the MTBC, which all share a recent common ancestor that is characterized by the deletion of the RD1mic region.

scholarly journals Complete Genome Sequences of Mycobacterium tuberculosis Isolates Subjected to 200 Continuous Passages

2020 ◽  
Vol 9 (26) ◽  
Author(s):  
Lucio Vera-Cabrera ◽  
Carmen A. Molina-Torres ◽  
Jose Marco Lopez-Ortiz ◽  
Jorge Castro-Garza ◽  
Carlos Cordova-Fletes ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Complete Genome ◽  
Draft Genome ◽  
Genome Sequences ◽  
Content Type

ABSTRACT We report 6 draft genome sequences corresponding to Mycobacterium tuberculosis H37Rv and M. tuberculosis DR689, a Beijing isolate, plus their counterparts subjected to 200 continuous passages in Middlebrook 7H9 broth, either alone or with ox bile.

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