Polymerization of (+)-Catechin in a Deep Eutectic Solvent Using a Fungal Laccase: Physicochemical Properties of the Products and Inhibition of α-Glucosidase

2021 ◽  
Vol 57 (6) ◽  
pp. 712-718
Author(s):  
M. E. Khlupova ◽  
O. V. Morozova ◽  
I. S. Vasil’eva ◽  
G. P. Shumakovich ◽  
E. A. Zaitseva ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Fungal Laccase

scholarly journals Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3279
Author(s):  
Ilma Nugrahani ◽  
Maria Anabella Jessica
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Strong Interactions ◽  
Green Method ◽  
Pharmaceutical Ingredients ◽  
Gastrointestinal Fluid ◽  
Non Covalent Interactions ◽  
Natural Deep Eutectic Solvent ◽  
Covalent Interactions

Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API’s physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API’s solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.

A functional natural deep eutectic solvent based on trehalose: Structural and physicochemical properties

2017 ◽  
Vol 217 ◽  
pp. 560-567 ◽  
Author(s):  
Ruipu Xin ◽  
Suijian Qi ◽  
Chaoxi Zeng ◽  
Faez Iqbal Khan ◽  
Bo Yang ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Natural Deep Eutectic Solvent

scholarly journals Experimental investigation on the correlation between the physicochemical properties and catalytic activity of six DESs in Kabachnik-Fields reaction

2020 ◽  
Author(s):  
Shaibuna Machingal ◽  
Sreekumar Krishnapillai
Keyword(s):  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Reaction Medium ◽  
Deep Eutectic Solvents ◽  
One Pot ◽  
Dimethyl Phosphite ◽  
Type Iv ◽  
Short Period ◽  
Regular Work ◽  
Work Up

Physicochemical properties of six Type IV- Deep eutectic solvents formed from ZrOCl2.8H2O/ CeCl3.7H2O   with urea, ethylene glycol & glycerol were compared. The study was performed by correlating the properties of DESs with their activity in Kabachnik-Fields reaction. Among the six DESs, lower density, viscosity, higher acidity & thermal stability were observed for DES 1(Deep eutectic solvent developed from ZrOCl2.8H2O and urea at 1: 5 ratio) and is reported as an excellent catalyst and reaction medium for the productive synthesis of α-aminophosphonates within a short period of time. One pot reaction of an aldehyde, dimethyl phosphite and amine (Kabachnik-Fields/ Phospha-Mannich reaction) took place at room temperature to give the corresponding α-aminophosphonates in good yield and the precipitation of these products in to water avoided the regular work up process. Catalyst was recycled up to five times without any loss in its activity.

scholarly journals Binary mixtures of choline chloride-based deep eutectic solvents as green extractants for the extraction of benzene from n-hexane

2021 ◽  
Author(s):  
Mohammed Awwalu Usman ◽  
Olumide Kayode Fagoroye ◽  
Toluwalase Olufunmilayo Ajayi ◽  
Abiola John Kehinde
Keyword(s):  
Physicochemical Properties ◽  
Binary Mixtures ◽  
Extraction Efficiency ◽  
Separation Efficiency ◽  
Choline Chloride ◽  
Mixed Solvents ◽  
Deep Eutectic Solvent ◽  
Volume Ratio ◽  
Ternary Systems ◽  
Distribution Coefficients

AbstractA suitable green solvent for extraction of aromatics from aliphatics must possess good solvation and physicochemical properties, a rare occurrence in a single deep eutectic solvent (DES). Mixture of DESs could enable synergy and provide a good candidate extractant. In this study, DESs of glyceline, ethaline, and reline were synthesized and their binary mixtures (glyceline/ethaline, reline/ethaline, and glyceline/reline) produced by blending in various volume proportions. Twelve of such mixed solvents were prepared and their extraction efficiency for separating benzene from n-hexane investigated in a batch equilibrium process. Liquid–liquid equilibria (LLE) data for the pseudo-ternary systems of n-hexane + benzene + mixed DESs were measured at 303 K and 101.3 kPa. The distribution coefficient (D) and selectivity (S) of each pseudo-ternary system were determined to elicit extraction efficiency. The physicochemical properties of the mixed DESs were also measured. The results show that generally the distribution coefficients, selectivities, and physicochemical properties of the mixed DESs lie between the corresponding values for the constituent DES. The best performance was given by the mixed solvent of glyceline and ethaline in the 80:20 volume ratio, respectively, with D = 0.75 and S = 422.485. This assertion was further corroborated by higher percent recovery of benzene obtained from the said mixed DES (57.88%) relative to other mixed DESs (≤ 49.11%) examined in this study. Furthermore, its separation efficiency is superior to sulfolane but lower than glyceline, though there was a 9.4% reduction in its viscosity relative to glyceline.

Sign in / Sign up

Export Citation Format

Share Document