Differences in the strategies and potentials of human adaptation to hypoxia

2007 ◽  
Vol 33 (3) ◽  
pp. 309-319
Author(s):  
E. A. Burykh ◽  
S. I. Soroko
Keyword(s):  
Adaptation To Hypoxia ◽  
Human Adaptation

scholarly journals The role of nitrogen oxides in human adaptation to hypoxia

2011 ◽  
Vol 1 (1) ◽  
Author(s):  
Denny Z. Levett ◽  
◽  
Bernadette O. Fernandez ◽  
Heather L. Riley ◽  
Daniel S. Martin ◽  
...  
Keyword(s):  
Nitrogen Oxides ◽  
Adaptation To Hypoxia ◽  
Human Adaptation

HYPOXIC ADAPTATION AND TRAINING: HISTORIC, BIOMEDICAL AND SPORT ASPECTS

2021 ◽  
Vol 55 (1) ◽  
pp. 20-26
Author(s):  
M.Yu. Zenko ◽  
◽  
Е.А. Rybnikova ◽  
Keyword(s):  
Adaptation To Hypoxia ◽  
Human Adaptation ◽  
Russian Science ◽  
Hypoxic Adaptation ◽  
Hypoxic Training ◽  
And Training

The review outlines the milestones in studying the processes of human adaptation to hypoxia, and hypoxic training applications in medicine and sports. Contribution of the Russian science to these investigations is disclosed and literary data on the mechanisms of hypoxic adaptation, models and effectiveness of hypoxic training are summarized. The paper is concluded by discussion of hypoxic training potential in high achievements sports.

scholarly journals Caudwell Xtreme Everest: a field study of human adaptation to hypoxia

Critical Care ◽  
2007 ◽  
Vol 11 (4) ◽  
pp. 151 ◽  
Author(s):  
Mike Grocott ◽  
Alan Richardson ◽  
Hugh Montgomery ◽  
Monty Mythen
Keyword(s):  
Field Study ◽  
Adaptation To Hypoxia ◽  
Human Adaptation

Psychophysiological correlates of human adaptation in Antarctica.

1989 ◽  
Author(s):  
Lawrence A. Palinkas ◽  
E. Eric Gunderson ◽  
Ralph G. Burr
Keyword(s):  
Human Adaptation ◽  
Psychophysiological Correlates

Narrative as active inference

2020 ◽  
Author(s):  
Nabil Bouizegarene ◽  
maxwell ramstead ◽  
Axel Constant ◽  
Karl Friston ◽  
Laurence Kirmayer
Keyword(s):  
Well Being ◽  
Social Practices ◽  
Human Adaptation ◽  
Active Inference ◽  
Future Projection ◽  
Future Developments ◽  
The Social ◽  
Parsimonious Model ◽  
Living Organisms ◽  
Theory Research

The ubiquity and importance of narratives in human adaptation has been recognized by many scholars. Research has identified several functions of narratives that are conducive to individuals’ well-being and adaptation as well as to coordinated social practices and enculturation. In this paper, we characterize the social and cognitive functions of narratives in terms of the framework of active inference. Active inference depicts the fundamental tendency of living organisms to adapt by creating, updating, and maintaining inferences about their environment. We review the literature on the functions of narratives in identity, event segmentation, episodic memory, future projection, storytelling practices, and enculturation. We then re-cast these functions of narratives in terms of active inference, outlining a parsimonious model that can guide future developments in narrative theory, research, and clinical applications.

LEVELS OF FREE PLASMA AMINO ACIDS UNDER ACUTE NORMOBARIC HYPOXIA IN VOLUNTEERS IN FASTED AND POSTPRANDIAL STATES

2020 ◽  
pp. 108-117
Author(s):  
A.A. Chernykh ◽  
N.N. Potolitsyna ◽  
E.A. Burykh ◽  
E.R. Boyko
Keyword(s):  
Amino Acids ◽  
Normobaric Hypoxia ◽  
Adaptation To Hypoxia ◽  
Plasma Amino Acids ◽  
Fed State ◽  
Metabolic Substrates ◽  
Overnight Fasting ◽  
Group 2 ◽  
Free Plasma ◽  
Group 1

The aim of the study was to assess the effect of acute normobaric hypoxia on free plasma amino acids (AA) in volunteers after overnight fasting and in the fed state. Materials and Methods. Group 1 (n=13, aged 22–32) participated in the study in the morning after overnight fasting. Group 2 (n=9, aged 22–32) took part in the study after a light fat-free breakfast. Acute normobaric hypoxia was achieved by breathing a hypoxic gas mixture (9 % O2 and 91 % N2) through a mask. According to the experimental protocol, blood sampling from the cubital vein was performed for analysis. Free plasma amino acids were analyzed using the Aracus amino acid analyzer. Results. Prior to the hypoxia onset, at the 5th and 20th minutes of hypoxia, no statistically significant differences in free AA levels were observed in the groups (p>0.05). At the 10th minute of hypoxia the levels of four AAs (serine, threonine, glutamine, and histidine) were significantly higher in Group 1 than in Group 2 (p<0.05). This was probably due to differences in functioning of several key “harmonizing” AA transporters (ASCT1 (SLC1A4), ASCT2 (SLC1A5) and LAT1 (SC7A5)), for which the AAs were metabolic substrates. It can be assumed, that such changes were caused by currently unclear mechanisms of fast regulation of AA transporter activity, associated with nutritional status. Conclusion. We believe that our findings may be important for providing better adaptation to hypoxia, and for more efficient correction of hypoxic negative effects. Keywords: acute normobaric hypoxia, free plasma amino acids, human. Цель исследования: изучить воздействие острой нормобарической гипоксии на метаболизм свободных аминокислот (АК) плазмы крови у добровольцев, участвовавших в исследовании натощак и после лёгкого завтрака. Материалы и методы. Первая группа добровольцев (22–32 года, n=13) участвовала в исследовании утром натощак, вторая группа (22–32 года, n=9) – через 2–3 ч после лёгкого безжирового завтрака. Гипоксия создавалась путём подачи через маску дыхательной смеси, содержащей 9 % О2 и 91 % N2. В соответствии с протоколом проводился периодический забор крови из локтевой вены для анализа. Оценка уровней свободных АК плазмы крови производилась с помощью аминокислотного анализатора Aracus. Результаты. До начала гипоксии, на 5-й и 20-й мин гипоксии уровни свободных АК в первой и второй группах значимо не различались (p>0,05). На 10-й мин гипоксии между первой и второй группами наблюдались статистически значимые различия уровней четырёх АК: глутамина, серина, треонина и гистидина (p<0,05). Это, вероятно, было обусловлено изменениями в работе «гармонизирующих» мембранных транспортёров (ASCT1 (SLC1A4), ASCT2 (SLC1A5) и LAT1 (SC7A5)), для которых эти АК являются обменными субстратами. Можно предположить, что данные изменения были опосредованы пока неясными механизмами быстрой регуляции активности этих транспортёров, зависящими от питания. Выводы. Мы полагаем, что полученные результаты могут иметь значение для обеспечения адаптации организма человека к острой гипоксии и эффективной коррекции последствий гипоксического воздействия. Ключевые слова: острая нормобарическая гипоксия, свободные аминокислоты плазмы крови, человек.

scholarly journals Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1102
Author(s):  
Alexander E. Kabakov ◽  
Anna O. Yakimova
Keyword(s):  
Heat Shock ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Liver Tumors ◽  
Oxygen Deficiency ◽  
Transarterial Embolization ◽  
Antiangiogenic Therapy ◽  
Adaptation To Hypoxia ◽  
Mesenchymal Transition

Within aggressive malignancies, there usually are the “hypoxic zones”—poorly vascularized regions where tumor cells undergo oxygen deficiency through inadequate blood supply. Besides, hypoxia may arise in tumors as a result of antiangiogenic therapy or transarterial embolization. Adapting to hypoxia, tumor cells acquire a hypoxia-resistant phenotype with the characteristic alterations in signaling, gene expression and metabolism. Both the lack of oxygen by itself and the hypoxia-responsive phenotypic modulations render tumor cells more radioresistant, so that hypoxic tumors are a serious challenge for radiotherapy. An understanding of causes of the radioresistance of hypoxic tumors would help to develop novel ways for overcoming this challenge. Molecular targets for and various approaches to radiosensitizing hypoxic tumors are considered in the present review. It is here analyzed how the hypoxia-induced cellular responses involving hypoxia-inducible factor-1, heat shock transcription factor 1, heat shock proteins, glucose-regulated proteins, epigenetic regulators, autophagy, energy metabolism reprogramming, epithelial–mesenchymal transition and exosome generation contribute to the radioresistance of hypoxic tumors or may be inhibited for attenuating this radioresistance. The pretreatments with a multitarget inhibition of the cancer cell adaptation to hypoxia seem to be a promising approach to sensitizing hypoxic carcinomas, gliomas, lymphomas, sarcomas to radiotherapy and, also, liver tumors to radioembolization.

scholarly journals Global evidence of constraints and limits to human adaptation

2021 ◽  
Vol 21 (3) ◽  
Author(s):  
Adelle Thomas ◽  
Emily Theokritoff ◽  
Alexandra Lesnikowski ◽  
Diana Reckien ◽  
Kripa Jagannathan ◽  
...  
Keyword(s):  
Climate Change ◽  
Systematic Review ◽  
Behavioral Adaptation ◽  
Human Adaptation ◽  
Small Islands ◽  
Intergovernmental Panel ◽  
Natural Systems ◽  
Adaptation Response ◽  
Cultural Constraints ◽  
Global Evidence

AbstractConstraints and limits to adaptation are critical to understanding the extent to which human and natural systems can successfully adapt to climate change. We conduct a systematic review of 1,682 academic studies on human adaptation responses to identify patterns in constraints and limits to adaptation for different regions, sectors, hazards, adaptation response types, and actors. Using definitions of constraints and limits provided by the Intergovernmental Panel on Climate Change (IPCC), we find that most literature identifies constraints to adaptation but that there is limited literature focused on limits to adaptation. Central and South America and Small Islands generally report greater constraints and both hard and soft limits to adaptation. Technological, infrastructural, and ecosystem-based adaptation suggest more evidence of constraints and hard limits than other types of responses. Individuals and households face economic and socio-cultural constraints which also inhibit behavioral adaptation responses and may lead to limits. Finance, governance, institutional, and policy constraints are most prevalent globally. These findings provide early signposts for boundaries of human adaptation and are of high relevance for guiding proactive adaptation financing and governance from local to global scales.

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