Normobaric interval hypoxytherapy in the correction of neuroimmunoendocrine disorders in children and adolescents with autoimmune thyroiditis

130 children and adolescents aged 6 to 16 years with a diagnosis of autoimmune thy-roiditis (AIT) at the stage of hypothyroidism underwent a course of hypoxytherapy. The high ef-ficiency of the normobaric interval hypoxic training method in the treatment of hypothyroidism on the background of AIT is shown. An increase in the function and number of CD8+ cells after a course of hypoxytherapy prevents the progression of the autoimmune process and promotes the restoration of thyroid function, which in turn leads to positive dynamics in the neurological status of patients: improved indicators of mental performance and fine coordination of move-ments. Key words: autoimmune thyroiditis, hypothyroidism, hypoxytherapy, interval hypoxic training, neuroimmunoendocrine disorders.

Exposure to Normobaric Hypoxia Combined with a Mixed Diet Contributes to Improvement in Lipid Profile in Trained Cyclists

This study aimed to analyze the effects of live high-train low method (LH-TL) and intermittent hypoxic training (IHT) with a controlled mixed diet on lipid profile in cyclists. Thirty trained male cyclists at a national level with at least six years of training experience participated in the study. The LH-TL group was exposed to hypoxia (FiO2 = 16.5%) for 11–12 h a day and trained under normoxia for 3 weeks. In the IHT group, participants followed the IHT routine three times a week under hypoxia (FiO2 = 16.5%) at lactate threshold intensity. The control group (N) lived and trained under normoxia. The results showed that the 3-week LH-TL method significantly improved all lipid profile variables. The LH-TL group showed a significant increase in HDL-C by 9.0% and a decrease in total cholesterol (TC) by 9.2%, LDL-C by 18.2%, and triglycerides (TG) by 27.6%. There were no significant changes in lipid profiles in the IHT and N groups. ∆TG and ∆TC were significantly higher in the LH-TL group compared to the N group. In conclusion, hypoxic conditions combined with a mixed diet can induce beneficial changes in lipid profile even in highly trained athletes. The effectiveness of the hypoxic stimulus is closely related to the hypoxic training method.

Effects of moderate-intensity intermittent hypoxic training on health outcomes of patients recovered from COVID-19: the AEROBICOVID study protocol for a randomized controlled trial

Background Recent studies point to a lower number and reduced severity of cases in higher altitude cities with decreased oxygen concentration. Specific literature has shown several benefits of physical training, so, in this sense, physical training with hypoxic stimulus appears as an alternative that supports the conventional treatments of the COVID-19 patient’s recovery. Thus, this study’s primary aim is to analyze the effects of moderate-intensity intermittent hypoxic training on health outcomes in COVID-19 recovered patients. Methods A clinical trial controlled double-blind study was designed. Participants (30–69 years old) will be recruited among those with moderate to severe COVID-19 symptoms, approximately 30 days after recovery. They will be included in groups according to the training (T) and recovery (R) association with hypoxia (H) or normoxia (N): (a) TH:RH, (b) TN:RH, (c) TN:RN, and last (d) the control group. The 8-week exercise bike intervention will be carried out with a gradual load increase according to the established periods, three times a week in sets of 5 min, 90 to 100% of the anaerobic threshold (AT), and a 2.5-min break. Blood will be collected for genotyping. First, after 4 weeks (partial), after 8 weeks, and later, 4 weeks after the end of the physical training intervention, participants will perform assessments. The primary outcome is the maximum oxygen consumption (VO2peak). The secondary outcomes include lung function, inflammatory mediators, hematological, autonomic parameters, AT, body composition analysis, quality of life, mental health, anthropometric measurements, and physical fitness. The statistical analysis will be executed using the linear regression model with mixed effects at a 5% significance level. Discussion This study is designed to provide evidence to support the clinical benefits of moderate-intensity intermittent hypoxic training as a part of the treatment of patients recovered from COVID-19. It may also provide evidence on the efficacy and safety of intermittent hypoxic training in different health conditions. Lastly, this study presents an innovative strategy enabling up to 16 participants in the same training session. Trial registration ClinicalTrials.gov RBR-5d7hkv. Registered after the start of inclusion on 3 November 2020 with the Brazilian Clinical Trials Registry

Effect of intermittent hypoxic intervention on aerobic and anaerobic performance of the elite athletes

Objective: The use of hypoxic training has increased to improve the performance of endurance athletes in recent years. Due to not having the suitable conditions and environment for each athlete and team, intermittent hypoxic training has been noted. The purpose of this study is to investigate the effect of intermittent hypoxic training on aerobic and anaerobic performance of elite athletes. Materials and Methods: A total of 40 elite distance athletes were taken into our study and divided into two groups as hypoxia and normoxia. While using the intermittent intervention for the hypoxic group 5 minutes intervals for a total of 1 hour per day, 3 days per week for a-4 week period, the same normoxic training protocol was used for the normoxic group. Aerobic and anaerobic performance parameters were measured with venous blood samples of the athletes in the first three days before and after hypoxic intervention. Results: When the hypoxia and normoxia groups were evaluated before and after intermittent hypoxia, there was no statistically change in aerobic and anaerobic performance values (p>0.05). Conclusion: We observed that there was not a statistical change of intermittent hypoxic intervention for the performances of hypoxic group. However, the more dose and the duration of hypoxic training, the more amount of performance gain can be achieved.

Nitric oxide and interval hypoxic training in COVID-19 rehabilitation— new research direction

COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, primarily affects lung tissue and disrupts gas exchange, leading to acute respiratory distress syndrome, systemic hypoxia, and lung damage. The search for methods of prevention and rehabilitation, especially after suffering from pneumonia caused by COVID-19, is on the agenda. This article discusses the possibilities of the interval hypoxic training (IHT) method for preventing infections by initiating nitric oxide production in the body. One of the main effects of IHT is the balanced stimulation of nitric oxide (NO) secretion. Over the past two decades, there has been an increasing interest in the function of nitric oxide (NO) in the human body. Nitric oxide plays a key role in maintaining normal vascular function and regulating inflammatory processes, including those leading to lung damage and the development of acute respiratory distress syndrome (ARDS). Our immune system destroys bacteria and viruses by oxidative burst, i.e. when oxygen accumulates inside the cell. This process also involves nitric oxide, a signaling molecule that has an antibacterial and antiviral effect, as well as regulates vascular tone and affects the permeability of the cell wall. Interval hypoxytherapy enhances endogenous oxidative protection and increases the amount of nitric oxide, thus allowing the body’s cells to resist infection more effectively. Mitochondrial NOS induction and mitochondrial NO synthesis increase under the action of pathogenic factors on the cell. By modulating the activity of mtNOS and the synthesis of mitochondrial NO, it is possible to increase the resistance to hypoxic effects. Interval hypo-hyperoxic training as an effective non-specific method of increasing the body’s defenses is indispensable not only in the prevention of viral infection, but also in rehabilitation after viral pneumonia, as well as as a method that reduces the severity of viral infection in the event of infection.

PECULIARITIES OF ETHANOL INTOXICATION OF ANIMALS AT APPLICATION OF INTERMITTENT HYPOXIC TRAINING AT THE BEGINNING OF ALCOHOL CONSUMPTION

Relevance. It was shown a wide therapeutic effects of intermittent hypoxic training (IHT) on the human organism which can increase the organism's resistance to damaging factors by inducing mechanisms of the safety use of energy resources. The objective: to investigate the protective effect of IHT applied at the beginning of the 30-day alcohol intoxication of rats on the redox processes and the state of the antioxidant system of blood and liver tissues. Materials and methods. The study was performed on white male rats, which were divided into four groups: the first - intact (control); animals of the second group received a 15% ethanol solution for 30 days as the only source of drink; third - animals under IHT; fourth - rats that IHT was applied at the beginning of 30 days alcohol intoxication. The amount of the consumed ethanol was monitored during the experiment. Intermittent hypoxic training was performed in the altitude chamber in the following mode: five 10-min “elevations” to a height of 6 km at a rate of 20 m/sec, intervals between the elevations being 30 min. The activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), total antioxidant activity (IAOA), as well as the content of lactic and pyruvic acids, malone dialdehyde and diene conjugates were determined. The research materials were homogenates of liver tissues and blood. The process is two-phase, which obviously reflects the stages of alcoholism. Results. It was found that alcohol intoxication of animals adapted to IHT is accompanied by an increase in the activity of superoxide dismutase and glutathione peroxidase in the blood and liver tissue against rats that consumed ethanol as the only source of drink. A tendency to increase IAOA and catalase activity against rats that received ethanol for a long time under these conditions was revealed. Analyzing the process of consumption of ethanol solution by animals, we can conclude that animals have a pronounced craving for alcohol in this model of alcoholization. The application of IHT at the beginning of alcohol intoxication as a protective agent delays the phase of formation of a pronounced craving for ethanol and reduces the amount of daily alcohol consumption. Conclusions. Thus, sessions of short-term hypoxic effects at the beginning of chronic ethanol consumption, provide an increase in the antioxidant defence of these animals relative to rats with alcohol intoxication.

THEORETICAL FOUNDATIONS OF STUDENTS ADAPTATION TO LEARNING LOADS BY MEANS OF HYPOXIC TRAINING

В данной статье указан литературный обзор о перспективном влиянии интервальной гипобарической гипоксии с нормоксии на учащихся высших учебных заведений. После длительного влияние сеансов наблюдалось корректировка их функционального состояние, повышение неспецифической резистентности к стрессу, снижения уровня холестерина, улучшение состояние сердечно-сосудистой системы. This article provides a literary review of the promising effect of interval hypobaric hypoxia with normoxia on students of higher educational institutions. After a longterm effect of the sessions, there was an adjustment in their functional state, an increase in nonspecific resistance to stress, a decrease in cholesterol levels, and an improvement in the state of the cardiovascular system.

Hypoxic training in qualified athletes

The paper presents the results of studies on the use of hypoxic training in athletes as a factor increasing physical performance.The article considers the use of altitude tents and hypoxic generators to create an artificial hypoxic environment in which an athlete spends time during night sleep and daytime rest.This work was aimed at testing an integrative approach to organizing the long-term training according to the Live High/Train Low method for qualified cross-country skiing athletes. Depending on the tasks and the availability of equipment, two options of artificial hypoxia are considered:Incrementally increasing hypoxic exposure without taking into account the individual athlete’s characteristics.Variable hypoxic exposure, taking into account individual characteristics.

Prevention and Treatment of Altitude Disease

The aim of the study is to determine the tactics of effective prevention and treatment of altitude sickness in the conditions of medium and high mountains. Materials and research methods. Domestic and foreign literature on altitude sickness are analyzed. The search was carried out using the electronic databases MEDLINE, Embase, Scopus, Web of Science, eLIBRARY for the period from 2013 to 2021. The following keywords and their combinations were used for the search: altitude sickness, treatment, prevention. Research results and their analysis. The features of the development of altitude sickness, risk factors, modern approaches to the treatment of this pathology, as well as the possibilities of pharmacological and non-pharmacological methods of prevention are considered. It is noted that the key method of preventing altitude sickness is a gradual ascent to great heights, and a promising method for its prevention can be an early implementation of interval hypoxic training. If one needs to quickly climb to heights of over 2.5 thousand meters, it is possible to use drugs such as acetazolamide and dexamethasone. In case of ineffectiveness of prevention and of development of any form of altitude sickness, the most effective treatment is an immediate descent to lower altitudes. If the descent is impossible, the use of oxygen and pharmacotherapy is justified, it is also possible to use hyperbaric chambers.