Molecular Variant Estimation of SLC11A1 Related Microsatellites in Chinese Indigenous Goats

2019 ◽  
Vol 55 (8) ◽  
pp. 993-999
Author(s):  
W.-W. Ni ◽  
G.-X. E ◽  
W.-D. Basang ◽  
Y.-B. Zhu ◽  
Y.-F. Huang
Diabetes ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1204-1208 ◽  
Author(s):  
D. G. Fogarty ◽  
J. C. Harron ◽  
A. E. Hughes ◽  
N. C. Nevin ◽  
C. C. Doherty ◽  
...  

2010 ◽  
Vol 44 (2) ◽  
pp. 115-116 ◽  
Author(s):  
G. Cossio – Gurrola ◽  
E. Arámbula – Meraz ◽  
M. Perea ◽  
N. García ◽  
A. Samudio Correa ◽  
...  

1988 ◽  
Vol 111 (2) ◽  
pp. 363-368 ◽  
Author(s):  
F. Ruvuna ◽  
T. C. Cartwright ◽  
H. Blackburn ◽  
M. Okeyo ◽  
S. Chema

SummaryData on gestation period of 701 indigenous East African and Galla does and pre- and postweaning growth of 810 pure-bred and cross-bred kids were analysed by least squares statistical analysis. Breeds of kids were East African, Galla, Toggenburg × East African, Toggenburg × Galla, Anglo-Nubian × East African and Anglo-Nubian × Galla. Average gestation length was 149 days and was significantly (P < 0·05) affected by type of birth of the kid, year–month of kidding, and age of dam. Does carrying twins had shorter gestation length than does carrying singles. Sex and breed of kid did not have significant effect on gestation length.Significant (P < 0·05) factors affecting birth weight, weight at 30, 60, 90, 120, 150, 210 and 270 days of age, and preweaning growth rate were breed and sex of kid, type of birth, year–month and age of dam. Male kids grew faster and were heavier than females. Kids born single were heavier and grew faster than twin-born kids. Kids from dams less than 3 years old weighed less than kids from older dams. Cross-bred kids had higher preweaning growth rates than indigenous pure-bred kids. The Anglo-Nubian × Galla cross was heaviest while the East African ranked lowest. The results point to importance of cross-breeding with temperate breeds to increase growth rates of indigenous goats. Comparison of Toggenburg and Anglo-Nubian sires for cross-breeding showed both buck breeds produced kids with roughly equal growth rates. Evaluation of indigenous Galla and East African dams for cross-breeding showed Galla dams produced heavier kids than East African but preweaning growth rates were not significantly different.


1989 ◽  
Vol 120 (2) ◽  
pp. 155-160 ◽  
Author(s):  
R. Swaminathan ◽  
R. K. Chin ◽  
T. T. H. Lao ◽  
Y. T. Mak ◽  
N. S. Panesar ◽  
...  

Abstract. Plasma total T4 (TT4), T3 (TT3), free T4 (FT4), free T3 (FT3), thyroxine binding globulin, hCG, and erythrocyte zinc content were measured in 43 women with uncomplicated pregnancy and in 71 patients admitted with hyperemesis gravidarum. Plasma concentration of thyroid hormones in hyperemesis subjects showed wide variability and 32% of subjects had high TT4 (higher than mean +2 sd of normal pregnant subjects), 33% had high FT4, 20% had high TT3, and 20% had high FT3. Red cell zinc content, a tissue marker of thyroid status, in the hyperthyroxinemic subjects was not different from that of normothyroxinemic hyperemesis subjects or of subjects with uncomplicated pregnancy. The elevated TT4 concentration decreased spontaneously in all but two of the hyperemesis subjects to normal pregnant levels. The plasma FT4 concentration at presentation correlated with plasma hCG in hyperemesis gravidarum (partial correlation coefficient r = 0.411, P< 0.01), but not in normal pregnancy (partial correlation coefficient r = 0.043) after allowing for the effect of gestational age. We conclude that approximately one third of hyperemesis subjects show transient hyperthyroxinemia and suggest that hCG or a molecular variant of hCG may stimulate the thyroid gland.


Author(s):  
Chao Yuan ◽  
Ting-ting Guo ◽  
Jian-bin Liu ◽  
Yao-jing Yue ◽  
Bo-hui Yang
Keyword(s):  

2019 ◽  
Vol 14 (2) ◽  
pp. 42-48
Author(s):  
N. G. Lyukshina

Pitt–Hoppkins syndrome is rare genetic disorder caused by a molecular variant of TCF4 which is involved in embryologic neuronal differentiation. The syndrome is characterized by specific facial dysmorphism, phychomotor delay, autistic behavior and intellectual disability. Other associated features include ealy-onset myopia, seizures, constipation and hyperventilation-apneic spells. We introduced a clinical case of the patient with molecularly confirmed TCF4 variant and previously undescribed combination with syndrome of the electrical status epilepticus during sleep.


2020 ◽  
Author(s):  
Raymond F. Robledo ◽  
Steven L. Ciciotte ◽  
Joel H. Graber ◽  
Yue Zhao ◽  
Amy J. Lambert ◽  
...  

AbstractStudies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5-13.5 due to severe hemorrhage and decreased fetal liver erythropoiesis. Conditional deletion in hematopoietic stem and progenitor cells (HSPCs) using Vav-Cre recapitulates the null phenotype demonstrating that RASA3 is required at the stem and progenitor level to maintain blood vessel development and integrity and effective blood production. In adults, bone marrow blood cell production and spleen stress erythropoiesis are suppressed significantly upon induction of RASA3 deficiency, leading to pancytopenia and death within two weeks. Notably, RASA3 missense mutations in mouse models scat (G125V) and hlb381 (H794L) show dramatically different hematopoietic consequences specific to both genetic background and molecular variant. Global transcriptomic studies in scat suggest potential targets to ameliorate disease progression.Author SummaryHematopoiesis is the process by which blood cells are formed. The individual must have a normal complement of red blood cells to prevent anemia, platelets to control bleeding, and white blood cells to maintain immune functions. All blood cells are derived from hematopoietic stem cells that differentiate into progenitor cells that then develop into mature circulating cells. We studied several mouse strains carrying different mutations in RASA3. We show that RASA3 is required at the earliest stages of blood formation, the stem and progenitor cells, and that the complement of genes other than RASA3, or the genetic background of the mutant strain, profoundly alters the overall effect on blood formation. Further, the molecular nature of the mutation in RASA3 also has a profound and independent effect on overall blood formation. One strain, designated scat, suffers cyclic anemia characterized by severe anemic crisis episodes interspersed with remissions where the anemia significantly improves. Comparison of scat crisis and remission hematopoietic stem and progenitor cells reveals striking differences in gene expression. Analyses of these expression differences provide clues to processes that potentially drive improvement of anemia in scat and provide new avenues to pursue in future studies to identify novel therapeutics for anemia.


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