Significance of Oxidative Damage to Proteins and DNA in the Blood of Patients with Parkinson’s Disease in Assessing the Severity of the Disease

Introduction.Fatigue syndrome is one of the nonmotor symptoms in Parkinson’s disease (PD). The aim of the study was assessment of prevalence of fatigue syndrome in PD and answering the question what are the independent risk factors connected with intensity of fatigue in PD.Methods. 114 patients with idiopathic PD (mean age 62.2 + 10.8 years) were enrolled. The fatigue was assessed according to the Fatigue Severity Scale (FSS). We analyzed associations between fatigue and sex, age, education, duration and severity of the disease, everyday activity, intensity of the main symptoms, treatment, presence of dyskinesias and fluctuations, depression and excessive sleep during the day, and presence of pain and nycturia.Results. The fatigue syndrome was detected in 57.9% of patients. The score in the FSS was 1 to 7 points, 4.3 average. Greater fatigue intensity correlated with higher total daily levodopa equivalent dose. Patients with moderate depression had significantly greater fatigue.Conclusions. Fatigue syndrome affects 57.9% of patients with PD. Use of higher LED and presence of moderate depression are independent risk factors of greater intensity of fatigue.

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Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

Brain Research ◽

10.1016/j.brainres.2010.02.031 ◽

2010 ◽

Vol 1328 ◽

pp. 139-151 ◽

Cited By ~ 142

Author(s):

Mohd.Moshahid Khan ◽

Ajmal Ahmad ◽

Tauheed Ishrat ◽

M. Badruzzaman Khan ◽

Md. Nasrul Hoda ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Oxidative Damage ◽

Rat Model ◽

Dopamine Depletion ◽

6 Hydroxydopamine

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Neurodegenerative changes of retina in Parkinson disease

Russian neurological Journal ◽

10.30629/2658-7947-2021-26-6-29-34 ◽

2022 ◽

Vol 26 (6) ◽

pp. 29-34

Author(s):

E. Yu. Fedotova ◽

N. V. Polkina ◽

E. N. Mikhailova ◽

S. N. Illarioshkin

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Structural Changes ◽

Diagnostic Value ◽

Control Group ◽

Rnfl Thickness ◽

Neurodegenerative Pathology ◽

Systemic Nature ◽

Severity Of The Disease ◽

Inferior Quadrant

In Parkinson’s disease (PD), some structural changes in the retina have been shown using optical coherence tomography (OCT). Among them most attractive are atrophic changes in retinal nerve fi ber layer (RNFL). However, diagnostic signifi cance of the OCT method in PD remains debatable. Objective: to investigate a thickness of RNFL in Parkinson’s disease patients and to determine the signifi cance of the OCT method in the PD diagnostics. Materials and methods. In PD patients (n = 24) and in a control group (n = 20) OCT was used to study the thickness of RNFL — average, in quadrants and in 10 sectors. Results. In patients with PD thinning of RNFL in the inferior quadrant was revealed (p = 0.009). The sensitivity and specifi city of the method were 56% and 82%, respectively. The thickness of RNFL was not associated with parkinsonian symptoms asymmetry, duration and severity of the disease. In the control group and in PD patients, there was a relationship between the RNFL thickness and age. Conclusion. PD is characterized by atrophic changes in the retina in the form of thinning of RNFL in the inferior quadrant, which confi rms the systemic nature of neurodegenerative pathology in this disease going beyond the substantia nigra and brain tissue. At the same time, the thickness of RNFL showed limited diagnostic value for detecting PD cases.

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The protective effects of citrullus colocynthis on inhibiting oxidative damage and autophagy-associated cell death in Parkinson's disease

Journal of the Taiwan Institute of Chemical Engineers ◽

10.1016/j.jtice.2019.04.003 ◽

2019 ◽

Vol 100 ◽

pp. 18-25 ◽

Cited By ~ 1

Author(s):

Yanmei Chen ◽

Yuliang Sa ◽

Guan Wang ◽

Xiaoli Pan ◽

Yongqi Zhen ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cell Death ◽

Oxidative Damage ◽

Protective Effects ◽

Citrullus Colocynthis

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Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype

International Journal of Molecular Sciences ◽

10.3390/ijms21176047 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6047

Author(s):

Huifangjie Li ◽

William C. Knight ◽

Pengfei Yang ◽

Yingqiu Guo ◽

Joel S. Perlmutter ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Oxidative Damage ◽

Lewy Body ◽

Dopamine Metabolism ◽

Tau Proteins ◽

Translocator Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Microglial Phenotype ◽

Tau Fibrils

We found interactions between dopamine and oxidative damage in the striatum involved in advanced neurodegeneration, which probably change the microglial phenotype. We observed possible microglia dystrophy in the striatum of neurodegenerative brains. To investigate the interactions between oxidative damage and microglial phenotype, we quantified myeloperoxidase (MPO), poly (ADP-Ribose) (PAR), and triggering receptors expressed on myeloid cell 2 (TREM2) using enzyme-linked immunosorbent assay (ELISA). To test the correlations of microglia dystrophy and tauopathy, we quantified translocator protein (TSPO) and tau fibrils using autoradiography. We chose the caudate and putamen of Lewy body diseases (LBDs) (Parkinson’s disease, Parkinson’s disease dementia, and Dementia with Lewy body), Alzheimer’s disease (AD), and control brains and genotyped for TSPO, TREM2, and bridging integrator 1 (BIN1) genes using single nucleotide polymorphisms (SNP) assays. TREM2 gene variants were absent across all samples. However, associations between TSPO and BIN1 gene polymorphisms and TSPO, MPO, TREM2, and PAR level variations were found. PAR levels reduced significantly in the caudate of LBDs. TSPO density and tau fibrils decreased remarkably in the striatum of LBDs but increased in AD. Oxidative damage, induced by misfolded tau proteins and dopamine metabolism, causes microglia dystrophy or senescence during the late stage of LBDs. Consequently, microglia dysfunction conversely reduces tau propagation. The G allele of the BIN1 gene is a potential risk factor for tauopathy.

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Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

Journal of Neural Transmission ◽

10.1007/s00702-019-02119-4 ◽

2019 ◽

Vol 127 (5) ◽

pp. 779-783 ◽

Cited By ~ 1

Author(s):

Hanxiang Liu ◽

Xianwen Wei ◽

Wen Yang ◽

Gavin P. Reynolds

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Uric Acid ◽

Risk Factor ◽

Oxidative Damage ◽

Southern China ◽

Substantial Reduction ◽

Agricultural Workers ◽

Neuroprotective Effects ◽

Established Risk Factor

AbstractMonoamine oxidase type B inhibitors act in Parkinson’s disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Another risk factor is low circulating uric acid (UA), which may relate to UA being the major endogenous antioxidant in the human body. We have undertaken a study of 192 initial admissions for PD in a general hospital neurology department in a partly rural region of Southern China to determine if there is an increased rate of PD in agricultural workers who have a high risk of exposure to pesticides, and how it may relate to deficits in UA. We found a disproportionately high number of agricultural workers admitted with PD (66.7% vs. 54.3% of all neurology admissions) and that PD subjects have a substantial reduction in UA. This is further reduced in agricultural workers and thus may contribute to the increased vulnerability of this group to PD.

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