scholarly journals SAT0202 Short-term erosive progression on magnetic resonance images is highly correlated with long-term radiographic progression in rheumatoid arthritis wrists

Author(s):  
M Østergaard ◽  
M Hansen ◽  
M Stoltenberg ◽  
KE Jensen ◽  
M Szkudlarek ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Andreas M. Weng ◽  
Herbert Köstler ◽  
Thorsten A. Bley ◽  
Christian O. Ritter

Abstract Background The effect of smoking on coronary vasomotion has been investigated in the past with various imaging techniques in both short- and long-term smokers. Additionally, coronary vasomotion has been shown to be normalized in long-term smokers by L-Arginine acting as a substrate for NO synthase, revealing the coronary endothelium as the major site of abnormal vasomotor response. Aim of the prospective cohort study was to investigate coronary vasomotion of young healthy short-term smokers via magnetic resonance cold pressor test with and without the administration of L-Arginine and compare obtained results with the ones from nonsmokers. Methods Myocardial blood flow (MBF) was quantified with first-pass perfusion MRI on a 1.5 T scanner in healthy short-term smokers (N = 10, age: 25.0 ± 2.8 years, 5.0 ± 2.9 pack years) and nonsmokers (N = 10, age: 34.3 ± 13.6) both at rest and during cold pressor test (CPT). Smokers underwent an additional examination after administration of L-Arginine within a median of 7 days of the naïve examination. Results MBF at rest turned out to be 0.77 ± 0.30 (smokers with no L-Arginine; mean ± standard deviation), 0.66 ± 0.21 (smokers L-Arginine) and 0.84 ± 0.08 (nonsmokers). Values under CPT were 1.21 ± 0.42 (smokers no L-Arginine), 1.09 ± 0.35 (smokers L-Arginine) and 1.63 ± 0.33 (nonsmokers). In all groups, MBF was significantly increased under CPT compared to the corresponding rest examination (p < 0.05 in all cases). Additionally, MBF under CPT was significantly different between the smokers and the nonsmokers (p = 0.002). MBF at rest was significantly different between the smokers when L-Arginine was given and the nonsmokers (p = 0.035). Conclusion Short-term smokers showed a reduced response to cold both with and without the administration of L-Arginine. However, absolute MBF values under CPT were lower compared to nonsmokers independently of L-Arginine administration.


2008 ◽  
Vol 8 (3) ◽  
pp. 292-294 ◽  
Author(s):  
Steven W. Hwang ◽  
Rafeeque A. Bhadelia ◽  
Julian Wu

✓Iophendylate (Pantopaque or Myodil) was commonly used from the 1940s until the late 1980s for myelography, cisternography, and ventriculography. Although such instances are rare, several different long-term sequelae have been described in the literature and associated with intrathecal iophendylate. The authors describe an unusual case of arachnoiditis caused by residual thoracic iophendylate imitating an expansile intramedullary lesion on magnetic resonance images obtained 30 years after the initial myelographic injection.


Author(s):  
Thafar S. A. Safar ◽  
Karmen B. Katay ◽  
Reem H. Khamis

At the end of 2019, coronavirus disease (COVID-19) outbreak is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Worldwide researchers and physician try to explore the mechanisms of damage induced by virus, they focus on the short-term and long-term immune-mediated consequences induced by the virus infection. Every day discover a new pathological condition induced by virus and new symptoms and disease may occur after recovery from disease. Our case report is 41 years old, Indian lady who presented to our primary health care centre complaining of multiple small hand joints pain, both elbows and knees pain with swelling of them and prolonged morning stiffness, diagnosed seropositive rheumatoid arthritis (RA) (arthritis, positive rheumatoid factor (RF), and X-ray changes) after 1 month recovery from COVID-19 infection. She did not have any joint pain and she had negative RF before COVID-19 infection with no family history of RA.


2020 ◽  
Vol 40 (1) ◽  
pp. 315-319
Author(s):  
W. Damman ◽  
R. Liu ◽  
M. Reijnierse ◽  
F. R. Rosendaal ◽  
J. L. Bloem ◽  
...  

AbstractAn exploratory study to determine the role of effusion, i.e., fluid in the joint, in pain, and radiographic progression in patients with hand osteoarthritis. Distal and proximal interphalangeal joints (87 patients, 82% women, mean age 59 years) were assessed for pain. T2-weighted and Gd-chelate contrast-enhanced T1-weighted magnetic resonance images were scored for enhanced synovial thickening (EST, i.e., synovitis), effusion (EST and T2-high signal intensity [hsi]) and bone marrow lesions (BMLs). Effusion was defined as follows: (1) T2-hsi > 0 and EST = 0; or 2) T2-hsi = EST but in different joint locations. Baseline and 2-year follow-up radiographs were scored following Kellgren-Lawrence, increase ≥ 1 defined progression. Associations between the presence of effusion and pain and radiographic progression, taking into account EST and BML presence, were explored on the joint level. Effusion was present in 17% (120/691) of joints, with (63/120) and without (57/120) EST. Effusion on itself was not associated with pain or progression. The association with pain and progression, taking in account other known risk factors, was stronger in the absence of effusion (OR [95% CI] 1.7 [1.0–2.9] and 3.2 [1.7–5.8]) than in its presence (1.6 [0.8–3.0] and 1.3 [0.5–3.1]). Effusion can be assessed on MR images and seems not to be associated with pain or radiographic progression but attenuates the association between synovitis and progression. Key Points• Effusion is present apart from synovitis in interphalangeal joints in patients with hand OA.• Effusion in finger joints can be assessed as a separate feature on MR images.• Effusion seems to be of importance for its attenuating effect on the association between synovitis and radiographic progression.


2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Chien-Wei Huang ◽  
Tsung-Han Yang ◽  
Guan-Bo Lin

Potholes, one of the major types of distress on pavement surfaces, damage vehicles and are a safety hazard for the travelling public. In order to mitigate the effect of potholes, cold-mix asphalt (CMA) patching materials are commonly used for urgent repair of pavement surfaces before resurfacing can be undertaken. Therefore, the short-term (initial stability) and long-term (in-service durability) performance evaluation of CMA patching materials is necessary. This study conducted several curing conditions in the laboratory to investigate short-term, long-term, and moisture effects on pavement surfaces. Moreover, this study compared the Marshall stability of samples prepared under various compaction conditions. Marshall stability, Cantabro abrasion, and UK wheel tracking tests were conducted to evaluate the performance of CMA patching materials. The results indicated that the Marshall stability of dense-gradation (DG) CMA patching materials was higher than that of open-graded (OG) CMA patching materials and the Marshall stability of OG CMA patching materials was highly influenced by the coarse aggregate proportion. The DG and OG CMA patching materials exhibited comparable abrasion resistance, and the Cantabro abrasion ratio was highly correlated to the estimated asphalt film thickness for the OG CMA patching materials. A moisture indicator (MI) was proposed, and the effect of moisture damage on Marshall stability and Cantabro abrasion ratio was related to the proposed MI. The rutting resistance of the DG CMA patching materials was higher than that of the OG CMA patching materials, which is consistent with the Marshall stability result.


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