AB1377 Clinical interest of bone marrow examination in rheumatology practice: An observationnal study of 257 patients

Pancytopenia is an important clinico-haematological entity and striking feature of many serious and life-threatening illnesses. Many haematological and non-haematological diseases involve the bone marrow primarily or secondarily and cause pancytopenia. Decrease in haemopoietic cell production, ineffective haemopoiesis and peripheral sequestration or destruction of the cells are the main pathophysiology of pancytopenia. The cause of pancytopenia thus may be lying in the bone marrow or in the periphery or both. Careful history, physical examination, simple blood work, review of the peripheral blood smear, sometimes bone marrow examination and trephine biopsy are required for diagnosis. Treatment and prognosis depend on the severity of pancytopenia and underlying pathology.

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Granulocytopenia Associated With Thymoma in a Domestic Shorthaired Cat

Journal of the American Animal Hospital Association ◽

10.5326/0440210 ◽

2008 ◽

Vol 44 (4) ◽

pp. 210-217 ◽

Cited By ~ 10

Author(s):

Janean L. Fidel ◽

Indira S. Pargass ◽

Michael J. Dark ◽

Shannon P. Holmes

Keyword(s):

Bone Marrow ◽

Radiation Therapy ◽

Immune Suppression ◽

Bone Marrow Examination ◽

Coarse Fraction ◽

External Beam ◽

Mass Treatment ◽

Left Shift ◽

Immune Mediated ◽

Blood Neutrophils

A 5-year-old, spayed female cat was referred because of a mass in the cranial mediastinum noted on thoracic radiographs. A thymoma was diagnosed following ultrasound and biopsy of the mass. Treatment was initiated with coarse-fraction radiation therapy using external-beam therapy (four fractions of 5 Gy). The mass responded, but granulocytopenia developed. Bone marrow examination showed a myeloid to erythroid ratio of approximately 1:1, with a left shift within the myeloid line. These findings, as well as the lack of toxic changes within the peripheral blood neutrophils, suggested immune-mediated destruction of peripheral granulocytes. Immune suppression with prednisone and cyclosporine was instituted. After 7 weeks, the neutrophil count returned to normal. The tumor was removed, and cyclosporine was reduced and eventually discontinued 3 weeks postsurgery.

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BONE MARROW PROFILE IN HEMATOLOGICAL DISORDERS IN YEMENI PATIENS

10.36106/ijar/2316392 ◽

2021 ◽

pp. 61-65

Author(s):

Saeed Thabet Nasher ◽

Fayed Alyousufy ◽

Khaled Alkubati ◽

Sadam Al Halimy ◽

Ramia Al Athwary

Keyword(s):

Bone Marrow ◽

Visceral Leishmaniasis ◽

Lymphoblastic Leukemia ◽

Bone Marrow Examination ◽

Myeloproliferative Disorder ◽

Lymphocytic Leukemia ◽

Published Data ◽

Hematological Disorders ◽

Hematological Diseases ◽

Age Related

There is paucity of information about the prevalence of hematological disorders in Yemen and neighboring countries .This is the rst project to evaluate the relative spectrum of hematological diseases in Taiz and Ibb governorate Yemen ,by method of bone marrow examination which is considered an important valuable diagnostic tool, for evaluation and nal diagnosis of various hematological and non-hematological disorders especially when CBC and peripheral blood lm study and other investigation failed to give a diagnosis . OBJECTIVES: The aim of this study was to evaluate the spectrum of haematological diseases diagnosed by bone marrow examination in Taiz and IBB governorates Yemen between September 2016 and October 2020 .Patients and method : A total of 1108 patients aged between (1 -100 )years old were evaluated by bone marrow examination at referral hematological center in IBB city Yemen . Relevant investigations were performed when needed. After exclusion of 98 patients with normal bone marrow ndings ,a total of 1010 patients had hematological disorders , and their data were analyzed. There were 527 (52.2 %) males and 483(47.8 %) females . A total of 655(64.9%) patients had benign hematological diseases and 355 (35.1% ) patients had malignant hematological diseases . RESULTS :A total of 138 patients had Iron deciency anemia ,107 had immune thrombocytopenic purpura (ITP) , 92 had hypersplenism,84 had Acute lymphoblastic leukemia ,79 had Acute myeloid leukaemia, 71 had megaloblastic anemia 58 had myeloproliferative disorder , 53 had Chronic myeloid leukemia , 45 had hemolytic anemia ,45had visceral leishmaniasis. 44 had malaria, 38 had chronic lymphocytic leukemia 38 had anemia of chronic disease ,25 had aplastic anemia ,25 had myelodysplastic syndromes, ,21 had anemia of infection ,19 had congenital syndroms,7had multiple myeloma ,6 had mixed deciency anemia and 5 had metastatic deposits , 4 had myeloid leukomoid reaction ,4 had lymphoma inltration and 2 had hairy cell leukemia . Sex- and age-related distribution of the various disorders was also presented. CONCLUSION: The anemias of all types were the most frequently encountered diagnosis followed by acute and chronic leukemias , ITP , Hypersplenism , ,myeloproliferative disorder , visceral leishmaniasis , malaria, myelodysplastic syndrome and congenital syndromes respectively. The other haematological disorders were less common. These ndings are comparable with published data in previous studies done in Yemen and other developing countries

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Myeloproliferative Neoplasm with Prominent Eosinophilia

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v31i3.20985 ◽

2014 ◽

Vol 31 (3) ◽

pp. 162-167

Author(s):

S Giti ◽

MN Bhuiyan ◽

MR Hossain ◽

MS Islam ◽

F Ahmed ◽

...

Keyword(s):

Bone Marrow ◽

Intensive Care ◽

Haematological Malignancy ◽

Past History ◽

Myeloproliferative Neoplasm ◽

Oral Prednisolone ◽

Bone Marrow Examination ◽

Atrial Thrombus ◽

Care Facilities ◽

History Of

The patient, a young soldier aged 36 years having past history of malaria, was admitted in CMH Dhaka on 17 August 2011 as a transferred case from CMH Saidpur and died on 22 August 2011. The deceased was admitted in CMH Saidpur on 05 August 2011 with high fever for 05 days along with generalized joint and muscle pain. In spite of all available treatment the patient was deteriorating and he was then transferred to CMH Dhaka. At that time the patient was febrile, dehydrated and toxic with lymphadenopathy, extremely tender joints and muscles. The patient rapidly developed acute kidney failure and gradually developed features of DIC. His bone marrow examination revealed dyserythropoiesis with predominantly eosinophilic granulopoiesis, suggestive of myeloproliferative neoplasm with prominent eosinophilia. The patient was treated with injectable antibiotics, antimalarial and oral prednisolone with all intensive care facilities. Ultimately all attempts were proved unsuccessful and he died on 22 August 2011 at 1700 hrs. On autopsy the deceased had intra atrial thrombus and possibly that was the immediate cause of death. A haematological malignancy, myeloproliferative neoplasm with prominent eosinophilia, can very well produce such a fatal condition. DOI: http://dx.doi.org/10.3329/jbcps.v31i3.20985 J Bangladesh Coll Phys Surg 2013; 31: 162-167

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THE UTILITY OF BLOOD AND BONE MARROW FILMS AND TREPHINE BIOPSY SECTIONS IN THE DIAGNOSIS OF PARASITIC INFECTIONS

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2015.039 ◽

2015 ◽

Vol 7 ◽

pp. e2015039 ◽

Cited By ~ 2

Author(s):

Clare Miller ◽

Barbara Bain

Keyword(s):

Bone Marrow ◽

Iron Deficiency Anaemia ◽

Parasitic Infection ◽

Clinical History ◽

Bone Marrow Examination ◽

Accurate Diagnosis ◽

Parasitic Infections ◽

Trephine Biopsy ◽

Deficiency Anaemia ◽

Blood Examination

The laboratory haematologist has a role in the diagnosis of parasitic infections. Peripheral blood examination is critical in the diagnosis of malaria, babesiosis, filariasis and trypanosomiasis. Bone marrow examination is important in the diagnosis of leishmaniasis and occasionally leads to the diagnosis of other parasitic infections. The detection of eosinophilia or iron deficiency anaemia can alert the laboratory haematologist or physician to the possibility of parasitic infection. In addition to morphological skills, an adequate clinical history is important for speedy and accurate diagnosis, particularly in non-endemic areas.

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Excess of Plasma Cells with Pseudo-Gaucher Cells in a Case of Tuberculosis - A Case Report

SAARC Journal of Tuberculosis Lung Diseases and HIV/AIDS ◽

10.3126/saarctb.v9i2.7976 ◽

2013 ◽

Vol 9 (2) ◽

pp. 30-32

Author(s):

A Palta ◽

P Dhiman ◽

J Ram

Keyword(s):

Bone Marrow ◽

Case Report ◽

Inflammatory Reaction ◽

Lung Diseases ◽

Plasma Cells ◽

Bone Marrow Examination ◽

Lytic Lesion ◽

Rare Finding ◽

Antitubercular Treatment ◽

Chronic Inflammatory Reaction

This report describes a case of 50 year old woman fever and bony pains with lytic lesion in skull. A polyclonal band was seen in γregion on serum electrophoresis. Bone marrow examination showed excess of plasma cells along with many Pseudo- Gaucher cells. The diagnosis of chronic inflammatory reaction was made. Although stain for AFB was negative, the patient responded to antitubercular treatment. The presence of pseudo-gaucher cells along with plasmacytosis is a rare finding in tuberculosis. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS; 2012; IX(2) 30-32 DOI: http://dx.doi.org/10.3126/saarctb.v9i2.7976

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An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature

Case Reports in Hematology ◽

10.1155/2018/7863943 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Kosuke Miki ◽

Naoshi Obara ◽

Kenichi Makishima ◽

Tatsuhiro Sakamoto ◽

Manabu Kusakabe ◽

...

Keyword(s):

Multiple Myeloma ◽

Bone Marrow ◽

Chronic Myeloid Leukemia ◽

Myeloid Leukemia ◽

Plasma Cells ◽

Bone Marrow Examination ◽

Bone Lesions ◽

Dexamethasone Treatment ◽

Lytic Bone Lesions

We report the case of a 76-year-old man who was diagnosed as having chronic myeloid leukemia (CML) with p190 BCR-ABL while receiving treatment for symptomatic multiple myeloma (MM). The diagnosis of MM was based on the presence of serum M-protein, abnormal plasma cells in the bone marrow, and lytic bone lesions. The patient achieved a partial response to lenalidomide and dexamethasone treatment. However, 2 years after the diagnosis of MM, the patient developed leukocytosis with granulocytosis, anemia, and thrombocytopenia. Bone marrow examination revealed Philadelphia chromosomes and chimeric p190 BCR-ABL mRNA. Fluorescence in situ hybridization also revealed BCR-ABL-positive neutrophils in the peripheral blood, which suggested the emergence of CML with p190 BCR-ABL. The codevelopment of MM and CML is very rare, and this is the first report describing p190 BCR-ABL-type CML coexisting with MM. Moreover, we have reviewed the literature regarding the coexistence of these diseases.

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