Abstract 17237: Physical Inactivity, Mortality and Incident Coronary Heart Disease in Blacks: The Jackson Heart Study

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Daisuke Kamimura ◽  
Loretta Cain ◽  
Donald T Clark ◽  
Cameron S Guild ◽  
Paul D Loprinzi ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sex Education ◽  
Physical Inactivity ◽  
Jackson Heart Study ◽  
Incident Coronary Heart Disease ◽  
Heart Study ◽  
Increased Risk ◽  
Significant Difference ◽  
Overall Mortality

Introduction: Despite reductions in overall mortality in recent decades, blacks continue to have higher death rates compared to whites. According to a recent CDC report, blacks were more likely to have a higher prevalence of unhealthy behaviors such as physical inactivity/sedentariness compared to whites. We assessed the associations between physical activity (PA) and incident coronary heart disease (CHD) and overall mortality in blacks in the Jackson Heart Study (JHS). Methods: Among the 5306 participants enrolled in JHS at baseline (2000-2004), we examined overall mortality through 2016, and among 3507 participants without prevalent CHD at baseline, clinically adjudicated incident CHD events (CHD hospitalizations and fatal myocardial infarction). Based on participant responses and the American Heart Association’s Life’s Simple 7 metrics, participants were classified as having poor (0 minutes/week), intermediate (&rt;0 and <75 minutes/week) or ideal (<=150 minutes/week) PA based on number of minutes of moderate of vigorous PA per week. Cox proportional hazard ratios (HR) were used to assess the relationships between PA categories and incident CHD and overall mortality. Results: Through 2016, there were 992 deaths (18.7% mortality rate) with higher rates in men (21.5%) compared with women (17.1%, p<0.0001). After adjustment for age, sex, education, systolic blood pressure, hypertension medications, diabetes, cholesterol, alcohol use and current smoking at baseline, poor PA was associated with increased mortality (HR 1.53, 95% CI 1.18, 1.98) compared to those with ideal PA. However, there was no significant difference in incident CHD events between those with ideal and poor PA (HR 1.05, 95% CI 0.66, 1.67). Compared with ideal PA, there was no significant difference in mortality in those with intermediate PA (HR 1.23, 95% CI 0.93, 1.62). Conclusions: In a large community-based cohort of blacks, lower PA was associated with higher overall mortality but was not associated with increased risk of incident CHD events.

scholarly journals Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study

2013 ◽  
Vol 74 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Ida K Haugen ◽  
Vasan S Ramachandran ◽  
Devyani Misra ◽  
Tuhina Neogi ◽  
Jingbo Niu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lower Limb ◽  
Framingham Heart Study ◽  
Cardiovascular Events ◽  
Physical Inactivity ◽  
Hand Osteoarthritis ◽  
Coronary Insufficiency ◽  
Heart Study ◽  
Increased Risk

ObjectivesTo study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed.MethodsWe examined whether symptomatic (≥1 joint(s) with radiographic OA and pain in the same joint) and radiographic hand OA (≥1 joint(s) with radiographic OA without pain) were associated with mortality and incident cardiovascular events (coronary heart disease, congestive heart failure and/or atherothrombotic brain infarction) using Cox proportional hazards models. In the adjusted models, we included possible confounding factors from baseline (eg, metabolic factors, medication use, smoking/alcohol). We also adjusted for the number of painful joints in the lower limb and physical inactivity.ResultsWe evaluated 1348 participants (53.8% women) with mean (SD) age of 62.2 (8.2) years, of whom 540 (40.1%) and 186 (13.8%) had radiographic and symptomatic hand OA, respectively. There was no association between hand OA and mortality. Although there was no significant relation to incident cardiovascular events overall or a relation of radiographic hand OA with events, we found a significant association between symptomatic hand OA and incident coronary heart disease (myocardial infarction/coronary insufficiency syndrome) (HR 2.26, 95% CI 1.22 to 4.18). The association remained after additional adjustment for pain in the lower limb or physical inactivity.ConclusionsSymptomatic hand OA, but not radiographic hand OA, was associated with an increased risk of coronary heart disease events. The results suggest an effect of pain, which may be a possible marker of inflammation.

scholarly journals Allostatic load in the association of depressive symptoms with incident coronary heart disease: The Jackson Heart Study

2019 ◽  
Vol 109 ◽  
pp. 104369 ◽  
Author(s):  
Shannon L. Gillespie ◽  
Cindy M. Anderson ◽  
Songzhu Zhao ◽  
Yubo Tan ◽  
David Kline ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Depressive Symptoms ◽  
Allostatic Load ◽  
Jackson Heart Study ◽  
Incident Coronary Heart Disease ◽  
Heart Study

Abstract P283: Associations of Adiponectin and Leptin with Incident Coronary Heart Disease and Ischemic Stroke in African Americans: The Jackson Heart Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Aurelian Bidulescu ◽  
Jiankang Liu ◽  
Zhimin Chen ◽  
Solomon K Musani ◽  
DeMarc A Hickson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
African Americans ◽  
Animal Models ◽  
Hdl Cholesterol ◽  
Jackson Heart Study ◽  
Incident Coronary Heart Disease ◽  
Heart Study

Background: In population studies leptin is directly associated with coronary heart disease (CHD) and ischemic stroke, but leptin’s proatherogenic properties in animal models are not clear. Opposite to leptin, adiponectin is atheroprotective in animal models but epidemiological investigations evaluating its role in cardiovascular disease (CVD) have been contradictory. Because the predictive significance of previously reported racial differences in adipokine levels remains unclear, we assessed the prospective association of the two adipokines with the risk of incident CVD events in African Americans (AA), known to have a high prevalence of cardiometabolic risk factors. Methods: Serum specimens from 5,108 AA Jackson Heart Study (JHS) participants without prevalent CVD at baseline examination (2000-2004) were analyzed by ELISA for adiponectin levels and by a radioimmunoassay method for leptin levels. Age-adjusted correlation coefficients and Cox proportional hazards regression models were used to estimate the associations of the two adipokines with incident CHD and incident ischemic stroke. Results: During 6.2 years average of follow-up, 164 incident CHD and 122 incident ischemic stroke events were documented. Among our study participants (63% women; mean age 54 ± 13 years), the mean (standard deviation, SD) was 6.14 (4.55) μg/mL in women and 4.19 (3.51) μg/mL in men for adiponectin and 37.54 (24.02) ng/mL in women and 11.30 (10.36) ng/mL in men for leptin. Adiponectin statistically significantly correlated with insulin resistance, as measured continuously by the homeostasis assessment model for insulin resistance, HOMA-IR (r = - 0.41 in women and r = - 0.30 in men) and with high-density lipoprotein cholesterol, HDL-cholesterol (r = 0.37 in women and r = 0.39 in men). Leptin significantly correlated with body mass index, BMI (r = 0.66 in women and r = 0.73 in men) and with HOMA-IR (r = 0.38 in women and r = 0.50 in men). After multivariate adjustment that included age, BMI, HDL-cholesterol, triglycerides, HOMA-IR, systolic blood pressure, hypertension medication, smoking and physical activity, adiponectin was marginally directly associated among women with incident CHD (HR = 1.27, 95% CI = 1.00 - 1.61 per 1 SD; p = 0.05), but not among men (p = 0.29). It was associated among women with incident stroke, HR = 1.36 (1.05 - 1.76) per 1 SD (p = 0.02), but not among men (p = 0.09). Leptin was not associated with incident CHD nor incident stroke. Conclusion: In the largest community-based cohort of African Americans, a higher adiponectin level was associated among women with a higher risk of incident stroke and marginally with a higher risk of incident coronary heart disease. Whether adiponectin harbors harmful properties, or it is produced in response to vascular inflammation to counter the atherosclerotic process, or the putative ’adiponectin resistance’ phenomenon acts, should be further investigated.

scholarly journals Risk factors of coronary heart disease: attitude and behaviour in family practice in Saudi Arabia

1999 ◽  
Vol 5 (1) ◽  
pp. 35-45 ◽  
Author(s):  
M. S. Khattab ◽  
M. A. Abolfotouh ◽  
W. Alakija ◽  
M. A. Al Humaidi ◽  
S. Al Wahat
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family Practice ◽  
Physical Inactivity ◽  
Fat Intake ◽  
Significant Difference ◽  
Lifestyle Questionnaire ◽  
Males And Females ◽  
The Mean

To study risk factors of attitudes and behaviour towards coronary heart disease [CHD], 280 Saudis > or = 20 years attending a family practice answered a structured health and lifestyle questionnaire and had their weight, height, blood pressure and random total cholesterol measured. Significant difference was found between males and females in the mean number of cardiovascular risk factors [t = -3.03, P < 0.01]. Few people with high dietary fat intake, obesity or physical inactivity perceived their behaviour as harmful. The number of people who perceived an associated risk to their health increased with incidence of smoking and obesity but not with high fat intake. Physically inactive people were least likely to perceive their behaviour as harmful

scholarly journals Joint modeling of longitudinal lipids and time to coronary heart disease in the Jackson Heart Study

2020 ◽  
Author(s):  
Wondwosen Kassahun-Yimer ◽  
Karen A Valle ◽  
Adebamike A Oshunbade ◽  
Michael E Hall ◽  
Yuan-I Min ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Joint Modeling ◽  
Survival Outcome ◽  
Jackson Heart Study ◽  
Modeling Framework ◽  
Bivariate Model ◽  
Modeling Approach ◽  
Longitudinal Response ◽  
Heart Study

Abstract Background: Multiple longitudinal responses together with time-to-event outcome are common in biomedical studies. There are several instances where the longitudinal responses are correlated with each other and at the same time each longitudinal response is associated with the survival outcome. The main purpose of this study is to present and explore a joint modeling approach for multiple correlated longitudinal responses and a survival outcome. The method will be illustrated using the Jackson Heart Study (JHS), which is one of the largest cardiovascular studies among African Americans. Methods: Four longitudinal responses, i.e., total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG) and inflammation measured by high-sensitivity C-reactive protein (hsCRP); and time-to-coronary heart disease (CHD) were considered from the JHS. The repeated lipid and hsCRP measurements from a given subject overtime are likely correlated with each other and could influence the subject's risk for CHD. A joint modeling framework is considered. To deal with the high dimensionality due to the multiple longitudinal profiles, we use a pairwise bivariate model fitting approach that was developed in the context of multivariate Gaussian random effects models. The method is further explored through simulations. Results: The proposed model performed well in terms of bias and relative efficiency. The JHS data analysis showed that lipid and hsCRP trajectories could exhibit interdependence in their joint evolution and have impact on CHD risk. Conclusions: We applied a unified and flexible joint modeling approach to analyze multiple correlated longitudinal responses and survival outcome. The method accounts for the correlation among the longitudinal responses as well as the association between each longitudinal response and the survival outcome at once. This helps to explore how the combination of multiple longitudinal trajectories could be related to the survival process.

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