FRI0432 Comparison of tests for lumbar flexion and hip function in patients with axial spondyloarthritis and in healthy controls

Objective.Enthesitis is the spondyloarthritis (SpA) landmark, but can also be seen after entheses overuse, such as during intensive sport.Methods.We aimed to compare entheses ultrasound (US) findings in a prospective cross-sectional study of 30 axial SpA cases, 30 athletes, and 29 controls.Results.Mean (SD) MAdrid Sonographic Enthesis Index (MASEI) score was 26.3 (13), 12.2 (7), and 10.4 (6) in patients with SpA, athletes, and non-athlete control groups, respectively (p < 0.0001).Conclusion.The MASEI score was significantly higher in patients with SpA compared with healthy controls, athletes, and non-athletes, and can be of value to distinguish SpA from healthy subjects, whatever their physical activity.

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Paravertebral Muscle Mechanical Properties in Patients with Axial Spondyloarthritis or Low Back Pain: A Case-Control Study

Diagnostics ◽

10.3390/diagnostics11101898 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1898

Author(s):

Sandra Alcaraz-Clariana ◽

Lourdes García-Luque ◽

Juan Luis Garrido-Castro ◽

I. Concepción Aranda-Valera ◽

Lourdes Ladehesa-Pineda ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Healthy Subjects ◽

Axial Spondyloarthritis ◽

Study Groups ◽

Healthy Controls ◽

Low Back ◽

Negative Consequences ◽

Muscle Properties ◽

Clinical Variables

Different musculoskeletal disorders are a source of pain in the spinal region; most of them can be divided into mechanical, such as low back pain (LBP), or inflammatory origins, as is the case of axial spondyloarthritis (axSpA). Nevertheless, insufficient information is available about the muscle negative consequences of these conditions. Thus, the objective of this study was to identify whether mechanical muscle properties (MMPs) of cervical and lumbar muscles are different between patients with axSpA, subacute LBP (sLBP), and healthy controls. Furthermore, we aimed identify whether MMPs were related to sociodemographic and clinical variables in various study groups. The MMPs, sociodemographic, and clinical variables were obtained in 43 patients with axSpA, 43 subjects with sLBP, and 43 healthy controls. One-way ANOVAs and ROC curves were applied to identify whether the MMPs could differentiate between the study groups. Intra-group Pearson r coefficients to test the associations between MMPs and the rest of the variables were calculated. The results showed that axSpA subjects have a higher tone and stiffness and a lower relaxation and creep than sLBP and healthy ones (p < 0.05). All lumbar and cervical MMPs, except for decrement, could correctly classify axSpA and healthy subjects and axSpA and sLBP patients (in both cases, Area Under the Curve > 0.8). However, no MMP could differentiate between sLBP and healthy subjects. Each group had a different pattern of bivariate correlations between MMPs and sociodemographic and clinical data, with a worse state and progression of the axSpA group associated with a higher tone and stiffness in both spinal regions. This study supports that MMPs are different and show different patterns of correlations depending on the type of spinal pain.

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Irritable bowel syndrome symptoms in axial spondyloarthritis more common than among healthy controls: is it an overlooked comorbidity?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2019-216134 ◽

2019 ◽

Vol 79 (1) ◽

pp. 159-161 ◽

Cited By ~ 1

Author(s):

Johan Karlsson Wallman ◽

Elisabeth Mogard ◽

Jan Marsal ◽

Kristofer Andréasson ◽

Anna Jöud ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Axial Spondyloarthritis ◽

Healthy Controls ◽

Irritable Bowel

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Differential expression of TLR2 and TLR4 in α4β7-positive leukocytes of patients with axial spondyloarthritis

Rheumatology ◽

10.1093/rheumatology/kez364 ◽

2019 ◽

Vol 59 (4) ◽

pp. 879-888

Author(s):

José Pablo Romero-López ◽

David Gómez-Martínez ◽

María Lilia Domínguez-López ◽

Luis Jiménez-Zamudio ◽

Julio César Casasola-Vargas ◽

...

Keyword(s):

Flow Cytometry ◽

T Cells ◽

Differential Expression ◽

Immune Cells ◽

Differentially Express ◽

Axial Spondyloarthritis ◽

Healthy Controls ◽

Toll Like Receptor ◽

Faecal Calprotectin ◽

Toll Like Receptor 2

Abstract Objectives Expression of α4β7 integrin can identify gut-homing immune cells. This study aimed to determine the expression of Toll-like receptor 2 (TLR2) and TLR4 in α4β7-positive leukocytes of patients with axial SpA (axSpA). Methods We analysed the frequencies of α4β7-positive T cells, Tγδ cells and monocytes in 14 patients with axSpA and 14 healthy controls, together with the expression of TLR2 and TLR4 by flow cytometry. Also, the concentration of faecal calprotectin was measured in all patients and controls. Results We found significantly higher percentages of α4β7-positive T (P = 0.026) and Tγδ cells (P = 0.0118) in the patients with axSpA than in controls; these cells showed differential expression of TLR2 and TLR4 when compared with α4β7-negative cells. Such differences were not correlated with disease activity or faecal calprotectin concentration. Conclusion There is an increase in circulating α4β7-positive T and Tγδ cells in patients with axSpA. These cells differentially express TLR2 and TLR4.

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