scholarly journals OP0184 The frequency of flares in subjects with chronic refractory gout treated with pegloticase is related to variation in the level of plasma urate

2018 ◽  
Author(s):  
L. Calabrese ◽  
T. Fields ◽  
A. Yeo ◽  
P. Lipsky
Keyword(s):  
Plasma Urate

Net urate reabsorption in the Dalmatian coach hound with a note on automated measurement of urate in species with low plasma urate

1982 ◽  
Vol 60 (12) ◽  
pp. 1499-1504 ◽  
Author(s):  
B. Moulin ◽  
P. Vinay ◽  
N. Duong ◽  
A. Gougoux ◽  
G. Lemieux
Keyword(s):  
Glomerular Filtration Rate ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Progressive Reduction ◽  
Clearance Ratio ◽  
Plasma Urate ◽  
Urate Reabsorption ◽  
Dalmatian Dog ◽  
Pyrazinoic Acid

A progressive reduction of renal blood flow and glomerular filtration rate induced by the stepwise clamping of a Goldblatt clamp increases the urate over creatinine clearance ratio from 1.2 to 1.9 in normal urate-secreting Dalmatian dogs. These clearance data support the existence of a predominant postreabsorptive secretory flux of urate in the normal Dalmatian dog. In contrast, in Dalmatians loaded with pyrazinoic acid which suppresses urate secretion, net reabsorption of urate is unmasked and the urate over creatinine clearance ratio decreases with the progressive reduction in glomerular filtration rate (down to 0.44). It is concluded that the net reabsorption of urate measured by conventional clearance techniques after pharmacologic depression of the urate secretory flux probably reflects true urate reabsorption in the nephron of this species.

scholarly journals RE: "PLASMA URATE AND RISK OF PARKINSON'S DISEASE"

2007 ◽  
Vol 167 (6) ◽  
pp. 752-753 ◽  
Author(s):  
B. L. Wise ◽  
T. Neogi ◽  
Y. Zhang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Plasma Urate

THE NORMAL RANGE OF PLASMA URATE LEVELS

1963 ◽  
Vol 12 (1) ◽  
pp. 46-52 ◽  
Author(s):  
B. T. EMMERSON ◽  
PAMELA SANDILANDS
Keyword(s):  
Normal Range ◽  
Plasma Urate

Uric acid metabolism in homozygous and heterozygous muscular dystrophic mice.

1978 ◽  
Vol 234 (4) ◽  
pp. E421
Author(s):  
M Y Dju ◽  
T F Yü
Keyword(s):  
Uric Acid ◽  
Acid Metabolism ◽  
Basal Diet ◽  
Elevated Plasma ◽  
Histological Evidence ◽  
Uric Acid Excretion ◽  
Plasma Urate ◽  
Dystrophic Mice ◽  
Uricase Activity ◽  
Oxonic Acid

The homozygous muscular dystrophic mice (dydy) were found to have significantly higher plasma uric acid than their heterozygous littermate controls (Dydy), and the Swiss albino mice. Because the rate of uric acid excretion did not compensate for the elevated plasma levels, U/P (urine/plasma) urate was lower in dydy mice. With RNA supplement, plasma and urinary urate were increased in both dydy and Dydy mice; again U/P urate was lower in dydy mice. It appears that the dydy mice to a certain extent are comparable to some gouty subjects, whose hyperuricemia is not accompanied by a corresponding increase in urinary uric acid. There was no difference in converting uric acid to allantoin either on basal diet alone or with RNA supplement. Oxonic acid effectively, though transiently, blocked the uricase activity in both dydy and Dydy mice resulting in hyperuricemia and hyperuricosuria with decreased allantoin. Uric acid content was increased markedly in the kidney without histological evidence of urate deposition, apparently related to the unsustained effect of oxonic acid, which was rapidly excreted.

Nature of urate transport in isolated rabbit proximal tubules

1981 ◽  
Vol 241 (5) ◽  
pp. F565-F578
Author(s):  
A. Shimomura ◽  
A. Chonko ◽  
R. Tanner ◽  
R. Edwards ◽  
J. Grantham
Keyword(s):  
Proximal Tubule ◽  
Kinetic Analysis ◽  
Plasma Levels ◽  
Proximal Tubules ◽  
Passive Component ◽  
Unidirectional Fluxes ◽  
Plasma Urate ◽  
The Relationship ◽  
Hill Plots ◽  
Urate Secretion

Unidirectional fluxes of [14C]-urate from bath to lumen and from lumen to bath were measured in isolated perfused rabbit proximal tubules. The absorption of urate from the perfusate was small in magnitude and relatively insensitive to alteration by luminal probenecid or D-glucose. By contrast, peritubular probenecid inhibited urate secretion from bath to lumen in all three segments. To estimate the facilitated component of urate secretion for each bath concentration of the anion, the passive component of urate influx (probenecid-resistant influx) was subtracted from the total influx of urate. Urate secretion was strongly dependent on concentration of urate in the bath, the relationship being sigmoidal in many S1 and S2 segments. The S0.5 values of 187,251, and 234 X 10(-6) M obtained from Hill plots of mean data from S1, S2, S3 segments, respectively, indicated that the secretory mechanism had a relatively uniform affinity for urate along the proximal tubule. Vmax values for urate secretion were 568,592, and 55 X 10(-15) mol . min-1 . mm-1 for the same segments. Kinetic analysis indicated that axial heterogeneity of urate secretion is probably due to differences in the relative densities of urate transporters of common affinity along the proximal tubule. We suggest that in intact rabbits with low plasma levels urinary urate is the product of glomerular filtration, passive reabsorption, and minimal proximal secretion. With elevation of plasma urate above endogenous levels, S1 and S2 segments secrete urate at an accelerated rate, possibly reflecting action of a transporter with allosteric features.

scholarly journals Ascorbate dynamics and oxygen consumption during arousal from hibernation in Arctic ground squirrels

2001 ◽  
Vol 281 (2) ◽  
pp. R572-R583 ◽  
Author(s):  
Ø. Tøien ◽  
K. L. Drew ◽  
M. L. Chao ◽  
M. E. Rice
Keyword(s):  
Peak Plasma ◽  
Plasma Concentrations ◽  
Metabolic Stress ◽  
Ground Squirrels ◽  
Electromyographic Activity ◽  
Spermophilus Parryii ◽  
Plasma Ascorbate ◽  
Leukocyte Counts ◽  
Plasma Urate ◽  
Arctic Ground Squirrels

During hibernation in Arctic ground squirrels ( Spermophilus parryii), O2 consumption and plasma leukocyte counts decrease by >90%, whereas plasma concentrations of the antioxidant ascorbate increase fourfold. During rewarming, O2 consumption increases profoundly and plasma ascorbate and leukocyte counts return to normal. Here we investigated the dynamic interrelationships among these changes. Plasma ascorbate and uric acid (urate) concentrations were determined by HPLC from blood samples collected at ∼15-min intervals via arterial catheter; leukocyte count and hematocrit were also determined. Body temperature, O2 consumption, and electromyographic activity were recorded continuously. Ascorbate, urate, and glutathione contents in body and brain samples were determined during hibernation and after arousal. During rewarming, the maximum rate of plasma ascorbate decrease occurred at the time of peak O2 consumption and peak plasma urate production. The ascorbate decrease did not correlate with mouth or abdominal temperature; uptake into leukocytes could account for only a small percentage. By contrast, liver and spleen ascorbate levels increased significantly after arousal, which could more than account for ascorbate clearance from plasma. Brain ascorbate levels remained constant. These data suggest that elevated concentrations of ascorbate {[Asc]} in plasma {[Asc]p} provide an antioxidant source that is redistributed to tissues during the metabolic stress that accompanies arousal.

scholarly journals Plasma urate concentrations and possible REM sleep behavior disorder

2019 ◽  
Vol 6 (12) ◽  
pp. 2368-2376
Author(s):  
Yun Shen ◽  
Junjuan Li ◽  
Michael Schwarzschild ◽  
Milena Pavlova ◽  
Songbin He ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Plasma Urate
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