scholarly journals AB1297-HPR BONE AND MINERAL METABOLISM IN SPONDYLOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1939.1-1939
Author(s):  
D. Castro-Corredor ◽  
M. A. Ramírez Huaranga ◽  
A. I. Rebollo Giménez ◽  
M. D. Mínguez Sánchez ◽  
J. Anino-Fernández ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Mineral Metabolism ◽  
Meta Analysis ◽  
Mineral Density ◽  
Cross Sectional ◽  
Vitamin D Levels

Background:Spondyloarthritis is the term for a group of inflammatory chronic diseases primarily affecting the axial skeleton, as well as the peripheral joints. Regarding bone metabolism in these patients, several studies have reported higher levels of inflammatory activity (BASDAI, BASMI, ESR and CRP) in patients with osteoporosis compared to those without this disease, although no correlations were found.Objectives:To describe clinical, serological and biological characteristics, as well as bone and mineral metabolism, according to analytical and densitometric criteria in a patient cohort with spondyloarthritis.Methods:Observational, descriptive and cross-sectional study. A retrospective review was conducted of a database of patients with spondyloarthritis treated during outpatient visits at the Rheumatology Department of Hospital General Universitario de Ciudad Real between June 2018 and June 2019. Variables are described using measures of frequency and of central tendency and dispersion.Results:Cohort of 115 patients (64 men and 51 women). Average age 45.97 years (+/- 13.41 SD). Ankylosing spondylitis in 54 patients, psoriatic arthropathy in 24, spondyloarthropathy associated with inflammatory bowel disease in 8, undifferentiated spondyloarthritis in 18 and other types of spondyloarthritis in 11. Regarding treatment, 40.88% of patients received disease-modifying drugs (methotrexate, sulfasalazine, etc.) and 43.4% received biologic drugs (86% anti-TNF alpha, 12% anti-IL-17 and 2% anti-IL-12/23). Moreover, 53.04% had received corticosteroids during some phase of their disease. Vitamin D levels were 23.81 (+/- 10.5 SD) and 77.4% of patients had a vitamin D deficiency/insufficiency. Of the total cohort, 34.78% presented osteopenia and 3.58% osteoporosis (T-Score and Z-Score).Conclusion:In this study, patients with spondyloarthritis show high percentages of osteopenia and osteoporosis, undiagnosed until this time, along with vitamin D deficiency. This data suggests higher prevalences of these metabolic bone diseases. Osteoporosis prevention is essential due to the risk of developing early fractures resulting from increased bone fragility.References:[1]Pray C, Feroz NI, Nigil Haroon N. Bone Mineral Density and Fracture Risk in Ankylosing Spondylitis: A Meta-Analysis. Calcif Tissue Int. 2017 Aug;101(2):182-192.[2]Zhang M et al. The association between ankylosing spondylitis and the risk of any, hip, or vertebral fracture: A meta-analysis. Medicine (Baltimore). 2017 Dec; 96(50): e8458.[3]Erten S, Kucuksahin O, Sahin A, Altunoglu A, Akyol M, Koca C. Decreased plasma vitamin D levels in patients with undifferentiated spondyloarthritis and ankylosing spondylitis. Intern Med. 2013;52(3):339-44[4]Mermerci B, Pekin Dogan Y, Sivas F, Bodur H, Ozoran K. The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis. Rheumatol Int 2010;30:375-381.[5]Arends S, Spoorenberg A, Bruyn W, Houtman PM, Leijsma MK, Kallenberg CGM, Brouwer E, van der Veerce. The relation between bone mineral density, bone turnover markers, and vitamin D status in ankylosing spondylitis patients with active disease: a cross-sectional analysis. Osteoporos Int 2011;22:1431-1439.[6]Lange U, Teichmann J, Strunk J, Iler-Ladner U, Schmidt KL. Association of 1.25 vitamin D2 deficiency, disease activity and low bone mass in ankylosing spondylitis.Disclosure of Interests:None declared

scholarly journals AB1281-HPR THE LEVELS OF VITAMIN D IN THE SPONDYLOARTHRITIS. DOES THE DEFICIT CORRESPOND TO THE INFLAMMATORY ACTIVITY?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1931.1-1931
Author(s):  
D. Castro-Corredor ◽  
M. A. Ramírez Huaranga ◽  
A. I. Rebollo Giménez ◽  
M. D. Mínguez Sánchez ◽  
J. Anino-Fernández ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Inflammatory Activity ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Inflammatory Bowel

Background:Spondyloarthritis is a group of chronic inflammatory diseases with involvement of the axial skeleton (mainly), and also of peripheral joints. Patients with spondyloarthritis have a significant prevalence of vitamin D levels below normal and that would correlate with the degree of activity of the disease.Objectives:To determine the association between vitamin D deficiency and the degree of activity of the disease (inflammatory activity) in a cohort of patients with spondyloarthritis.Methods:Case-control type analytical observational study. We propose a retrospective review of the database of patients with spondyloarthritis (according ASAS2010 criteria) who were treated in the outpatient clinics of the Rheumatology Service of the General University Hospital of Ciudad Real during June 2018 to June 2019. Patients with the data will be selected. necessary for the analysis of the variables under study. The numerical variables of normal distribution evaluated will be described using measures of frequency and measures of central tendency / dispersion as appropriate. To assess the association between vitamin D levels and activity index, the odds ratio (OR) is calculated, with a 95% confidence level and the T-student for related samples.Results:The final results of the study are presented. 115 patients were analyzed, of which 64 were men and 51 women, with an average age of 45.97 years (+/- 13.41 DE). 47% were ankylosing spondylitis, 21% psoriatic arthropathy, 16% undifferentiated spondyloarthritis, 7% spondyloarthropathy associated with inflammatory bowel disease and 9% were spondyloarthropathy associated with inflammatory bowel disease. The average of the activity was a BASDAI of 4.57 (+/- 2.35 SD) and measured by DAPSA was 12.61 (+/- 6.76 SD). 63 and 14 patients had activity measured by BASDAI and DAPSA, respectively. 49.56% patients presented an elevation of acute phase reactants. Vitamin D levels were 23.81 (+/- 10.5 SD). 77.4% presented figures of vitamin D deficiency or insufficiency. When performing the association analysis, the vitamin D deficit / insufficiency presented an OR 10 (95% CI: 3.66-27.29, p=<0.0001) with the degree of activity measured with BASDAI and DAPSA and against the elevation of RCP it was 3.63 (95% CI 1.43-9.25, p = 0.0092) and against the elevation of ESR it was 2.76 (95% CI 1.09-7, 0, p = 0.0438). Regarding the comparative analysis of means between vitamin D deficiency/insufficiency and BASDAI/DAPSA it was +3.29 (95% CI: 1.34-8.09, p=0.0084).Conclusion:Patients with spondyloarthritis, as in other autoimmune diseases, vitamin D deficiency is associated with increased inflammatory activity (BASDAI, DAPSA, RCP and ESR), measured in different time periods. Therefore, an optimization of vitamin D levels can imply an improvement in the patient’s clinical situation, measured by both BASDAI and DAPSA, as well as by RCP and ESR.In addition, it is necessary to monitor bone mineral density due to the risk of fracture in these patients for their multietiology (corticosteroid treatments, biological FAMEs, inflammatory activity).References:[1]Lange U, Teichmann J, Strunk J, Müller-Ladner U, Schmidt KL. Association of 1.25 vitamin D3 deficiency, disease activity and low bone mass in ankylosing spondylitis. Osteoporos Int. 2005;16:1999-2004.[2]Durmus B, Altay Z, Baysal O, Ersoy Y. Does vitamin D affect disease severity in patients with ankylosing spondylitis? Chin Med J. 2012;125:2511-2515.[3]Mermerci Baskan B, Pekin Dogan y, Sivas F, Bodur H, Ozoran K. The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis. Rheumatol Int. 2010;30:375-381.Disclosure of Interests:None declared

scholarly journals The relation between disease activity, vitamin D levels and bone mineral density in men patients with ankylosing spondylitis

2013 ◽  
Vol 5 (1) ◽  
pp. 3 ◽  
Author(s):  
Ihsane Hmamouchi ◽  
Fadoua Allali ◽  
Btissam El Handaoui ◽  
Hanae Amine ◽  
Samira Rostom ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vitamin D Levels

Juvenile lupus and serum vitamin D levels: A cross-sectional study

Lupus ◽  
2020 ◽  
Vol 29 (13) ◽  
pp. 1752-1758
Author(s):  
Samar abd Alhamed Tabra ◽  
Hend Hassan Abdelnabi ◽  
Nivine Fathi Mahmoud Darwish ◽  
Amal Mohammed El-Barbary ◽  
Muhammad Tarek AbdelGhafar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Healthy Children ◽  
Z Score ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Significant Difference

Background Juvenile systemic lupus erythematosus (JSLE) is usually associated with vitamin D deficiency and low bone mineral density. Objectives To evaluate serum levels of 25-OH vitamin D in JSLE patients and to correlate these findings with disease activity and bone density. Methods This study was conducted on 100 patients with JSLE and 100 healthy children as controls. Disease duration and SLEDAI for disease activity were evaluated. CBC, anti-dsDNA, C3,C4,24hr urinary proteins, creatinine, estimated glomerular filtration rate(e-GFR),Ca,P,PTH, 25 (OH) D levels, and bone mineral density(BMD)Z score were measured. Results There were significant differences in mean 25(OH)D concentration between patients group (19.37 ± 9.72 ng/ml) and controls 35.90 ± 9.66 ng/ml(p < 0.05), with significant difference between active and inactive patients (p < 0.05).There were significant negative correlations between serum 25(OH)D and SLEDAI (r-0.545, p 0.001), steroid dose (r-0.561, p 0.001), anti-dsDNA (r-0.685, p 0.006), 24 hr-proteinuria (r-0.738, p 0.001) and PTH (r-0.335, p 0.001), significant positive correlations between 25(OH)D and C3 (r0.617, p 0.001),C4 (r0.544, p 0.001) serum Ca (r0.424, p 0.001) and Z score (r0.561, p 0.001),with non-significant correlations between 25(OH)D and serum P and both disease & steroid duration, (p > 0.05). Conclusion Vitamin D deficiency is common in JSLE, it’s correlated significantly with disease activity and bone mineral density.

AB0673 SHINING LIGHT ON AXIAL SPONDYLOARTHRITIS: DISEASE ACTIVITY AND VITAMIN D. WHAT’S THE LINK?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1631.1-1632
Author(s):  
G. A. Brown ◽  
K. M. Torsney ◽  
E. Nikiphorou
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Axial Spondyloarthritis ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly involving the axial skeleton and sacroiliac joints. Although the exact aetiology remains largely unknown, there is thought to be an immune-driven element. Vitamin D deficiency has been associated with a number of autoimmune diseases and is thought to play an important role in modulating the immune system. Low vitamin D levels may contribute to the development and progression of axSpA1.Objectives:To study the possible associations between low vitamin D and disease activity in axSpA.Methods:A systematic literature search using Medline, Embase and Cochrane was performed using MESH search terms “ankylosing spondylitis”, “axial spondyloarthropathy” and “vitamin D”. Articles examining disease activity measured by BASDAI, ASDAS-CRP, ESR and CRP identified through title/abstract screening, were included in the study, with relevant information extracted.Results:Out of 495 articles identified from the initial search, 19 observational studies which were mostly (89%) cross-sectional studies were identified. There was considerable heterogeneity between studies, including in the definition of vitamin D deficiency, latitude where study took place and seasonal variation. Vitamin D levels were often lower in patients with axSpA compared to controls. Seventeen studies found no association with vitamin D deficiency and disease activity. The exceptions included one study which measured serum vitamin D receptor levels as opposed to serum 25 (OH) D or 1,25 (OH)2 D concentrations, and another study whose recruitment occurred over four years and therefore seasonal variation may conflict results. Patients taking NSAIDs or anti-TNF had no difference in vitamin D levels.Conclusion:Vitamin D deficiency is more prevalent in axSpA but does not seem to associate with increased disease activity. Longitudinal studies are required to better define these links.References:[1]Sizheng Z, et al. Systematic review of association between vitamin D levels and susceptibility and disease activity of ankylosing spondylitis. Rheumatology 2014; 53:1595-1603.Disclosure of Interests:None declared

scholarly journals Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

2019 ◽  
Vol 12 (2) ◽  
pp. 44-49
Author(s):  
AKM Shaheen Ahmed ◽  
Wasim Md Mohosin Ul Haque ◽  
Khwaja Nazim Uddin ◽  
Fadlul Azim Abrar ◽  
Farhana Afroz ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Age Groups ◽  
Urban Hospital ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Ipth ◽  
Vitamin D Levels

Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD. Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined. Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively). Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status. IMC J Med Sci 2018; 12(2): 44-49

scholarly journals Bioavailable vitamin D levels are reduced and correlate with bone mineral density and markers of mineral metabolism in adults with nephrotic syndrome

Nephrology ◽  
2016 ◽  
Vol 21 (6) ◽  
pp. 483-489 ◽  
Author(s):  
Abhinav Aggarwal ◽  
Ashok K Yadav ◽  
Raja Ramachandran ◽  
Vinod Kumar ◽  
Vivek Kumar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Bioavailable Vitamin D

scholarly journals Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
bin Yi ◽  
Rui-han Lian ◽  
Ping-an Qi ◽  
Tao Yuan ◽  
Pei-jing Yan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Preterm Birth ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Second Trimester ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Vitamin D Levels

Abstract Background: Current studies suggest that vitamin D deficiency during pregnancy can produce a certain effect for preterm birth, but there is no research showing whether vitamin D deficiency has a consistent effect in different pregnancies; thus, we conducted a systematic review and meta-analysis of 24 observational studies, grouping them according to the gestational age at the time of serum sampling, to investigate whether vitamin D deficiency in different periods of gestation has different effects on preterm birth and to provide an evidence-based basis for pregnant women to measure and supplement vitamin D. Methods: The databases PubMed-Medline, EMBASE, the Cochrane Library, Web of Science, EBSCO, CBM, and CNKI were searched until July 2019. Two researchers independently assessed the eligibility and quality of studies, and STATA 12.0 software was used for meta-analysis. Result: Seven cohort studies, 13 case-control studies, and four cross-sectional studies were included from 2500 articles by inclusion and exclusion criteria. After adjusting for age, race, and other confounding factors, meta-analysis results showed that vitamin D deficiency in the first trimester, the second trimester and the third trimester did not increase the risk of preterm birth (odds ratio (OR) = 1.01, 95% confidence interval (CI) (0.88, 1.16), P = 0.867; OR = 1.12, 95%CI (0.92, 1.37), P = 0.249; OR = 1.05, 95%CI (0.87, 1.27), P = 0.602). However, there was moderate heterogeneity in the study of vitamin D deficiency in the second trimester, and subgroup analysis suggested that vitamin D deficiency in the second trimester may increase the risk of preterm birth (OR = 1.33, 95%CI (1.15, 1.54), P = 0.000). A sensitivity analysis of the second trimester showed that excluding any one study did not significantly change the results. Conclusions: Vitamin D deficiency in early and late pregnancy may not be associated with preterm birth, while vitamin D deficiency in middle pregnancy is likely to have an important effect on preterm birth. Vitamin D levels should be measured in the second trimester of pregnancy, and vitamin D supplements should be provided if necessary.

scholarly journals The Prevalence and Risk Factors of Osteoporosis among a Saudi Female Diabetic Population

2017 ◽  
Vol 5 (2) ◽  
pp. 177-181
Author(s):  
Ibrahim Abdulrazag AL-Homood ◽  
Iman Sheshah ◽  
Abdel Gaffar A. Mohammed ◽  
Gasim I. Gasim
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Self Report ◽  
Hypoglycemic Agents ◽  
Oral Hypoglycemic Agents ◽  
Mineral Density ◽  
Cross Sectional ◽  
Vitamin D Levels

 AIM: This study aimed to assess the prevalence and determinants of osteoporosis [lumbar spine (LS) and femoral neck (FN)] among patients with type 2 diabetes at King Salman Hospital.MATERIALS AND METHODS: One hundred seventy patients with type 2 diabetes were enrolled in this cross-sectional study in the period from the 1st of January until the 1st of July 2015. Patient selection was based on self-report of the previous diagnosis by a physician, being on an antidiabetic agent, or a fasting glucose of 126 mg/dl as per the American Diabetes Association criteria. A dual energy X-ray absorptiometry scan with the bone mineral density (BMD) categorization based on the WHO cut of levels of T-scores and determination of vitamin D levels were performed. A detailed questionnaire was used to collect demographic data.RESULTS: Out of 170 participants, 50 (29.4%) were diagnosed as having osteoporosis, while 68 (40%) were diagnosed with osteopenia. Age was determined as a risk factor for a decreased BMD in patients with osteopenia (odds ratio (OR) = 1.1, 95% confidence interval (CI) = (1.0-1.1), p = 0.039) and osteoporosis (OR = 1.1, CI = 1.0-1.2, p < 0.001). Similarly, oral hypoglycemic agents (OHA) increased the risk of decreased BMD in osteopenia (OR = 2.6; CI = 1.0-6.7; p = 0.023) as well as osteoporosis, (OR = 3.8; CI = 1.3-10.9; p = 0.013), while vitamin D deficiency increased the risk of osteopenia OR = 3.0; CI = 1.2-7.2; p = 0.012). Increased BMI decreased the risk of both osteopenia and osteoporosis (OR = 0.9; CI = 0.9-0.99; p = 0.031 vs. OR = 0.9; CI = 0.80-0.95; p = 0.003).CONCLUSION: Advanced age, OHA and vitamin D deficiency are determinants of decreased BMD in Saudi women with type 2 diabetes, while an increased BMI protects against low BMD.

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