scholarly journals AB0868-HPR ADHERENCE TO DISEASE-MODIFYING ANTIRHEUMATIC DRUGS IN RHEUMATIC DISEASES DURING COVID-19 PANDEMIC

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1458.1-1458
Author(s):  
I. A. Moreno-Arquieta ◽  
G. G. Sánchez Mendieta ◽  
D. E. Flores Alvarado ◽  
J. A. Esquivel Valerio ◽  
D. Á. Galarza-Delgado
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Sclerosis ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Electronic Monitoring ◽  
The United States ◽  
Self Report ◽  
University Hospital ◽  
Inflammatory Myopathies ◽  
Systemic Lupus

Background:The pandemic COVID-19 has set a new challenge in adherence to treatment in patients with rheumatic diseases. Prior studies in Latin America had reported adherence of 16.4% on Rheumatoid Arthritis (RA) and 45.9% in Systemic Lupus Erythematous (SLE). There is evidence that these patients believe their treatment increases the risk and gravity of COVID-19 and therefore, suspending the treatment could reduce this risk. It has been shown that a “Good adherence” is associated to a better survival.Objectives:Describe the adherence to DMARDs in patients with Rheumatic diseases during COVID-19.Methods:Descriptive, cross-sectional, self-report study conducted in rheumatology outpatient clinic of University Hospital in Monterrey, México. Consecutive patients with RA, SLE, Inflammatory Myopathies and Systemic Sclerosis, were approached during their routine appointments, March 2020 to December 2020 period during COVID-19 pandemic. They were asked how many days of the month they took the DMARD indicated in the previous appointment, with Based on this, adherence was classified into four categories: Good 100-75% (> 21 days), Regular 74-50% (21-15 days), Bad 49-25% (14-8 days) and Null <25% (<7 days). Data was obtained from our internal electronic patient record registry and analyzed with SPSS V.22.Results:n (DMARDs)GoodRegularBadNulln (%)n (%)n (%)n (%)Rheumatoid Arthritis302255 (84.4)13 (4.3)20 (6.6)14 (4.6)Systemic Lupus Erithematous126111 (88)3 (2.3)8 (6.3)4 (3.1)Inflammatory Myopathies1110 (90.9)0 (0)1 (9)0 (0)Systemic Sclerosis3027 (90)2 (6.6)1 (3.3)0 (0)TOTAL469Conclusion:Despite what it is believed, patients are not changing therapeutic regimes. The adherence found in this group of patients was good, for the definition used in this study. It should be considered that the self-report method may overestimate adherence, so the data found must be correlated with objective methods in the future.References:[1]Resende Prudente L, Souza Diniz J, Matteucci Ferreira TXA, Marçal Lima D, Antônio Silva N, Saraiva G, et al. Medication adherence in patients in treatment for rheumatoid arthritis and systemic lupus erythematosus in a university hospital in Brazil. Patient Preference and Adherence. 2016:10 863–870.[2]Michaud K, Wipfler K, Shaw Y, et al. Experiences of patients with rheumatic diseases in the United States during early days of the COVID-19 pandemic. ACR Open Rheumatol 2020. doi:10.1002/acr2.11148.[3]Waimann ChA, Marengo MF, de Achaval S, Cox VL, Garcia-Gonzalez A, Reveille JD. Electronic Monitoring of Oral Therapies in Ethnically Diverse and Economically Disadvantaged Patients With Rheumatoid Arthritis. Arthritis & Rheumatism. 2013:6 1421-1429.Disclosure of Interests:None declared

scholarly journals Autoimmune thyroid disease and associated rheumatic disorders

2005 ◽  
Vol 133 (Suppl. 1) ◽  
pp. 55-60 ◽  
Author(s):  
Djunajdar Kerimovic-Morina
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Systemic Lupus ◽  
Autoimmune Thyroid ◽  
Antithyroid Antibodies

Musculosceletal manifestations were found in patients with hyperthyroidism as well as hypothyroidism. This article will review the available evidence that autoimmune thyroid disease is associated with: Sj?gren?s sydrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis, rheumatoid arthritis (RA) and spondyloarthropathies. Possible pathogenesis of these manifestations has not been completely established. Sj?gren?s syndrome occurs in about 1/10 of patients with autoimmune thyroid disease; patients with SLE and antithyroid antibodies were significantly older than those pattiens without antibodies. Patients with systemic sclerosis and thyroid disease were significantly younger than those without antibodies. Thyroid disfunction was found three times more often in women with RA than in women with noninflammatory rheumatic diseases, and those with thyroid disease tended to have a shorter duration of arthritis.

scholarly journals AB0427 ANTI-NOR90 AUTOANTIBODIES: FAVORABLE OR UNFAVORABLE PROGNOSIS?

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1241.3-1242
Author(s):  
C. Valero ◽  
J. P. Baldivieso ◽  
I. Llorente ◽  
E. F. Vicente-Rabaneda ◽  
L. Esparcia Pinedo. ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Rna Polymerase ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Sjogren's Syndrome ◽  
Organ Involvement ◽  
Systemic Lupus

Background:Anti-NOR 90 autoantibodies (anti-NOR90 Ab) are autoantibodies that target nucleolar transcription factor 1 or hUBF, involved in transcription of RNA polymerase I. These autoantibodies have been detected in 6.1% of patients with Systemic Sclerosis (SSc), but their clinical or prognostic significance has not been clearly defined. Anti-NOR90 Ab have been mostly associated with limited scleroderma with mild organ involvement and can also be found in other rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus or Sjogren’s syndrome.Objectives:The aim of this study was to identify the main clinical characteristics of patients with positive anti-NOR90 in our Centre.Methods:This is a retrospective, descriptive, cross-sectional study of all patients with positive anti-NOR90 Ab between January 2013 and December 2020 in a single center. Autoantibodies testing was performed using Euroimmun EUROLINE SSc profile IgG autoAb assay kit. Patient demographics, clinical characteristics, associated diagnoses, laboratory and immunological findings were collected.Results:We identified a total of 26 patients with at least a positive value for anti-NOR90 Ab (Table 1). In most cases anti-NOR90 patients were ANA positive, predominantly with nucleolar pattern and coexisted with other SSc autoantibodies. 12 patients had rheumatic diseases and two had SSc, both with limited cutaneous SSc and absence of organ involvement. 14 patients had no definite diagnosis. Clinical features of anti-NOR90 patients are represented in Figure 1. Five patients presented Raynaud’s phenomenon, two cases with pathological nailfold capillaroscopy and one patient had SSc. There was no patient with skin ulcers, calcinosis, interstitial lung disease or pulmonary hypertension. Four patients had gastroesophageal reflux disease and one patient presented antral vascular ectasia. Six patients developed some neoplasm.Figure 1.Clinical characteristics of anti-NOR90 Ab patients.Conclusion:In our case series anti-NOR90 Ab were associated with multiple rheumatic diseases with heterogeneity of clinical manifestations. We did not observe a further progression to SSc or presence of organ involvement or severe scleroderma, so these autoantibodies could be related with a favorable prognosis. In contrast with previous reports, a striking association with cancer has been detected in our population.Table 1.Demographic characteristics and main diagnoses of anti-NOR90 positive patients.CharacteristicsTotal Anti-NOR90: 26 patientsSex, n19 women/ 7 menAge, mean (years)58,9 IQR [46,3-72,2]Race, nAsian: 1; Hispanic: 7; Caucasian: 18Smoker, n3Positive ANA (>1/160), nPattern, n247 Homogeneous, 4 Nucleolar, 4 Speckled, 1 Centromere, 5 Speckled -nucleolar, 3 Homogeneous-nucleolar.Positive ENA, n32 Anti-SSA-Ro52 and Ro60, 1 anti-RNP and anti-SmSystemic sclerosisautoantibodies, n•Anti-Ku: 7•Anti-U3RNP (Fibrilarin): 6•Anti-RNA polymerase III: 5•Anti Th/To: 4•Anti-centromere: 4 (CENP B +/- CENPA)•Anti-topoisomerase I: 2•Anti-Ro52: 3•Anti-PM-Scl: 3Main diagnosis, n12 Rheumatic diseases:2 systemic Sclerosis (2 limited/0 diffuse)1 rheumatoid arthritis1 LES1 Sjögren’s syndrome,3 undifferentiated conective tissue disease2 overlap (1 Sjögren + LES, 1 Sjögren + MCTD 1)s: 1 morphea, 1 cutaneous graft versus host diseaseNeoplasm, n6: 2 solid organ cancer (bladder, kidney), 1 lung adenocarcinoma, 1multiple myeloma, 1 acute myeloid leukemia: 1 basal cell carcinoma.Abbreviations: LES: systemic lupus erythematosus; MCTD: mixed connective tissue diseaseDisclosure of Interests:None declared

Pericyte Ultrastructural Pathology in Autoimmune Inflammatory Myopathies

1998 ◽  
Vol 4 (S2) ◽  
pp. 1080-1081
Author(s):  
H.J. Finol ◽  
A. Marquez ◽  
M. Pulido-Mendez ◽  
B. Muller ◽  
I. Montes de Oca ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lupus Erythematosus ◽  
University Hospital ◽  
Inflammatory Myopathies ◽  
Systemic Lupus ◽  
Cell Degeneration ◽  
Ultrastructural Pathology ◽  
Transmission Electron ◽  
Capillary Endothelial Cells ◽  
Muscle Biopsies

Ultrastructural Pathology of capillary endothelial cells in autoimmune inflammatory myopathies has been intensively investigated in the last two decades, but much less is known about the alterations of capillary pericytes. In other diseases as diabetes and arterial hypertension perycites abnormalities have been reported. In this work we report the pericyte ultrastructural pathology in autoimmune inflammatory myopathies.Patients admitted to the study were attending the rheumatology clinics at the Caracas University Hospital. Diagnoses were systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and muscle paraneoplastic phenomenon.Needle muscle biopsies were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.Two different processes were observed, pericyte hypertrophy and cell degeneration. In the first one cytoplasmic proliferation is evident (Fig. 1). Some capillaries embraced by the pericyte were found (Fig. 2). In the second one cytoplasmic vacuolation and capillary necrosis (Fig. 3) were evident. Usually, pericyte and endothelial degeneration were concomitant.

scholarly journals Patients with Systemic Sclerosis with and without Overlap Syndrome Show Similar Microvascular Abnormalities

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1606
Author(s):  
Gabriella Nagy ◽  
László Czirják ◽  
Gábor Kumánovics
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Sclerosis ◽  
Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Capillary Density ◽  
Overlap Syndrome ◽  
Inflammatory Myopathies ◽  
Systemic Lupus ◽  
Control Groups ◽  
Morphology Parameters

Introduction: Nailfold video capillaroscopy (NVC) is a useful tool for measuring capillary density (CD) and capillary morphology parameters and is mainly used in systemic sclerosis (SSc). Objective: We aimed to assess the prevalence of an SSc pattern and CD in different connective tissue diseases (CTDs). Methods: NVC was performed on 268 patients with CTDs. Control groups consisted of 104 healthy volunteers (HVs) and 36 primary Raynaud’s patients (PRPs). Results: Decreased CD was more prevalent in SSc, systemic lupus erythematosus (SLE), inflammatory myopathies (IIM), and overlap CTD patients compared with both controls. Average CD, the prevalence of decreased CD, and the prevalence of an SSc pattern did not differ significantly between SSc patients with (n = 39) and without (n = 50) overlap syndrome. An SSc pattern was significantly more prevalent in SLE (23%), SSc (82%), IIM (35%), and rheumatoid arthritis (17%) compared with both control groups. The prevalence of an elevated microangiopathy evaluation score (MES) was significantly higher in SLE, SSc, and IIM than in the HVs. Conclusion: The presence of another CTD in SSc did not influence CD or morphology. An SSc pattern may also be present in CTDs other than SSc. The MES is a useful instrument to distinguish between patients with CTDs and controls.

scholarly journals Osteoporosis in Rheumatic Diseases

2019 ◽  
Vol 20 (23) ◽  
pp. 5867 ◽  
Author(s):  
Adami ◽  
Fassio ◽  
Rossini ◽  
Caimmi ◽  
Giollo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Special Focus ◽  
Systemic Lupus ◽  
Treatment Of Osteoporosis ◽  
Increased Risk ◽  
Crystal Induced Arthritis

Osteoporosis is a chronic disease characterized by an increased risk of fragility fracture. Patients affected by rheumatic diseases are at greater risk of developing osteoporosis. The purpose of the present review is to discuss the pathogenesis, epidemiology, and treatment of osteoporosis in patients affected by rheumatic diseases with special focus for rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, systemic lupus erythematosus, systemic sclerosis, vasculitides, Sjogren syndrome, and crystal-induced arthritis.

Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis

2014 ◽  
Vol 33 (8) ◽  
pp. 1093-1098 ◽  
Author(s):  
Lisbeth Aranbicia Aguila ◽  
Michelle Remião Ugolini Lopes ◽  
Flavia Zon Pretti ◽  
Percival Degrava Sampaio-Barros ◽  
Fernando Henrique Carlos de Souza ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Lupus Erythematosus ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Systemic Lupus ◽  
Overlap Syndromes ◽  
Laboratory Features

scholarly journals POS1172 COVID-19 ACROSS RHEUMATOLOGY: A BIBLIOMETRIC STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 866.2-867
Author(s):  
B. Doskaliuk ◽  
R. Yatsyshyn ◽  
I. Stoika ◽  
K. Fedorovych ◽  
O. Drogomeretska ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Systemic Sclerosis ◽  
Open Access ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Scientific Data ◽  
Research Field ◽  
Systemic Lupus ◽  
Biological Drugs

Background:The Coronavirus disease 2019 (COVID-19) outbreak spread rapidly among the whole world, becoming the greatest pandemic for the decades. It triggered the enormous challenges for the global health system, forcing doctors and patients to adapt to new realities and the field of rheumatology was not an exclusion.Objectives:The aim of this study was to analyze articles covering interconnection between COVID-19 and rheumatic diseases; to investigate the common features of papers in this category and indicate the most influential among them; to determine which rheumatic nosologies were most represented.Methods:For retrieving of literature data, we applied the bibliometric database Scopus and conducted our search on 12th of January using following keywords: “rheumatoid arthritis” OR “systemic lupus erythematosus” OR “systemic sclerosis” OR “vasculitis” OR “myositis” OR “rheumatology” AND “COVID-19”. All selected articles were analyzed according to various aspects: type of document, authorship, journal, citations score, rheumatology field, country of origin, language, and keywords. We have built the visualizing keywords network (Figure 1) with the help of software tool VOSviewer version 1.6.15 (the minimum keyword occurrence threshold was set at 5).Figure 1.Results:A total of 844 literature items were obtained. After screening of title, abstract and keywords we excluded 106 records as they were not emphasized the rheumatological perspective on COVID-19 and as a result were inapplicable for this study. The 738 retrieved articles were mostly (86.8%) open access publications. The top five journals that contributed most to the coverage of this topic were: Annals Of The Rheumatic Diseases (n=59), Clinical Rheumatology (n=41), Lancet Rheumatology (n=24), Arthritis And Rheumatology (n=20) and Rheumatology International (n=19). The origin of most studies was not surprisingly from those countries, which belong to the top ten according to the total cases of COVID-19 [1] (USA – 167; Italy – 148; UK – 76; India – 60 and Spain – 58). Most items were written in English but articles in German (n=12), Spanish (n=11), Russian (n=5) and Chinese (n=2) could also be found. Analyzed studies were designed in the form of Original Articles (41.2%), Reviews (23.7%), Letters (21.8), Notes (6.9%), Editorials (5.1%). According to the citations scores, articles of highest interest were dedicated to clinical course of COVID-19 in patients with autoimmune pathologies. The other highly cited studies were about cytokine storm and perspective usage of biological drugs for severe cases of COVID-19. Our analysis of keywords showed that the most widely discussed rheumatic disease in the view of COVID-19 was systemic lupus erythematosus (n=188), followed by vasculitis (n=132), rheumatoid arthritis (n=90), systemic sclerosis (n=32) and psoriatic arthritis (24). The liveliest discussion about disease-modifying antirheumatic drugs in COVID-19 revolved around hydroxychloroquine (n=305), corticosteroids (n=161), tocilizumab (n=83), methotrexate (n=46) and anakinra (n=34).Conclusion:As far as we know, it is the first bibliometric overview of studies dedicated to interrelation between COVID-19 and rheumatic pathology. The high number of open access items contributes to the increase of research visibility in this emergently developing research field and facilitates the process of scientific data sharing. The conducting of bibliographic studies may provide a valuable guide through this area of knowledge.References:[1]https://www.worldometers.info/coronavirus/ Accessed on January 12, 2021Disclosure of Interests:None declared.

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