Maternal weight and infections in early childhood: a cohort study

ObjectiveThe aim of this study was to examine this association between maternal weight during pregnancy and the incidence of hospitalisations for infectious diseases during early childhood.DesignA population-based cohort study.SettingA national cohort was created by combining data from the Swedish Medical Birth Register, the National Inpatient Register, the Cause of Death Register, the Total Population Register and the Longitudinal integration database for health insurance and labour market studies.Patients693 007 children born in Sweden between 1998 and 2006.Main outcome measuresNumber of hospitalisations for infectious diseases during the first 5 years of life, overall and for categories of infectious diseases (lower respiratory, enteric, upper respiratory, genitourinary, perinatal, skin and soft tissue, neurological and eye, digestive tract, bloodstream and other infections).ResultsOverweight (body mass index (BMI) 25.0–29.9) and obesity (BMI≥30) during pregnancy were associated with a higher overall incidence of hospitalisations for infectious diseases, adjusted incidence rate ratio (IRR) 1.05 (95% CI 1.03 to 1.06) and adjusted IRR 1.18 (95% CI 1.16 to 1.21). Overweight and obesity during pregnancy were strongly associated with perinatal infections, adjusted IRR 1.34 (95% CI 1.25 to 1.44) and adjusted IRR 1.72 (95% CI 1.57 to 1.88). In contrast, we found no association between maternal weight during pregnancy and infections of skin and soft tissue, the nervous system, the digestive tract or the bloodstream.ConclusionsWe observed an association between overweight and obesity during pregnancy, and hospitalisations for infectious diseases during early childhood.

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P08 Epidemiology of epilepsy in early childhood and predictors of outcome: a national population-based prospective cohort study

10.1136/archdischild-2020-rcpch.19 ◽

2020 ◽

Author(s):

JD Symonds ◽

KS Elliott ◽

JC Knight ◽

A Jollands ◽

E Pilley ◽

...

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Population Based ◽

Predictors Of Outcome ◽

National Population

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Gestational Age and Cognitive Ability in Early Childhood: a Population-based Cohort Study

Paediatric and Perinatal Epidemiology ◽

10.1111/ppe.12058 ◽

2013 ◽

Vol 27 (4) ◽

pp. 371-379 ◽

Cited By ~ 43

Author(s):

Gry Poulsen ◽

Dieter Wolke ◽

Jennifer J Kurinczuk ◽

Elaine M Boyle ◽

David Field ◽

...

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Cognitive Ability ◽

Gestational Age ◽

Population Based

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Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2006.12.639 ◽

2007 ◽

Vol 119 (4) ◽

pp. 930-936 ◽

Cited By ~ 33

Author(s):

Aida Semic-Jusufagic ◽

Claus Bachert ◽

Philippe Gevaert ◽

Gabriele Holtappels ◽

Lesley Lowe ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Early Childhood ◽

Cohort Study ◽

Birth Cohort ◽

Allergic Disease ◽

Population Based ◽

Birth Cohort Study ◽

Childhood Population

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Perinatal outcomes of maternal overweight and obesity in term infants: a population-based cohort study in Canada

Scientific Reports ◽

10.1038/srep09334 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 16

Author(s):

Angela Elena Vinturache ◽

Sheila McDonald ◽

Donna Slater ◽

Suzanne Tough

Keyword(s):

Cohort Study ◽

Perinatal Outcomes ◽

Population Based ◽

Overweight And Obesity ◽

Term Infants ◽

Maternal Overweight

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Prevalence and prognostic impact of comorbidity in soft tissue sarcoma: A population-based cohort study

Acta Oncologica ◽

10.3109/0284186x.2014.888494 ◽

2014 ◽

Vol 53 (9) ◽

pp. 1188-1196 ◽

Cited By ~ 14

Author(s):

Katja Maretty-Nielsen ◽

Ninna Aggerholm-Pedersen ◽

Akmal Safwat ◽

Steen Baerentzen ◽

Alma B. Pedersen ◽

...

Keyword(s):

Cohort Study ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Population Based ◽

Prognostic Impact

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Early Childhood Infectious Diseases and the Development of Asthma up to School Age: A Birth Cohort Study

PEDIATRICS ◽

10.1542/peds.110.s2.447a ◽

2002 ◽

Vol 110 (Supplement_2) ◽

pp. 447-448

Author(s):

Wanda Phipatanakul

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Infectious Diseases ◽

Birth Cohort ◽

Birth Cohort Study ◽

School Age

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Is maternal weight gain between pregnancies associated with risk of large-for-gestational age birth? Analysis of a UK population-based cohort

BMJ Open ◽

10.1136/bmjopen-2018-026220 ◽

2019 ◽

Vol 9 (7) ◽

pp. e026220 ◽

Cited By ~ 7

Author(s):

Nida Ziauddeen ◽

Sam Wilding ◽

Paul J Roderick ◽

Nicholas S Macklon ◽

Nisreen A Alwan

Keyword(s):

Weight Gain ◽

Gestational Age ◽

Population Based ◽

Overweight And Obesity ◽

Large For Gestational Age ◽

Adjusted Relative Risk ◽

Maternal Weight ◽

Overweight Women ◽

Increased Risk ◽

Maternal Overweight

ObjectiveMaternal overweight and obesity during pregnancy increases the risk of large-for-gestational age (LGA) birth and childhood obesity. We aimed to investigate the association between maternal weight change between subsequent pregnancies and risk of having a LGA birth.DesignPopulation-based cohort.SettingRoutinely collected antenatal healthcare data between January 2003 and September 2017 at University Hospital Southampton, England.ParticipantsHealth records of women with their first two consecutive singleton live-birth pregnancies were analysed (n=15 940).Primary outcome measureRisk of LGA, recurrent LGA and new LGA births in the second pregnancy.ResultsOf the 15 940 women, 16.0% lost and 47.7% gained weight (≥1 kg/m2) between pregnancies. A lower proportion of babies born to women who lost ≥1 kg/m2(12.4%) and remained weight stable between −1 and 1 kg/m2(11.9%) between pregnancies were LGA compared with 13.5% and 15.9% in women who gained 1–3 and ≥3 kg/m2, respectively. The highest proportion was in obese women who gained ≥3 kg/m2(21.2%). Overweight women had a reduced risk of recurrent LGA in the second pregnancy if they lost ≥1 kg/m2(adjusted relative risk (aRR) 0.69, 95% CI 0.48 to 0.97) whereas overweight women who gained ≥3 kg/m2were at increased risk of new LGA after having a non-LGA birth in their first pregnancy (aRR 1.35, 95% CI 1.05 to 1.75). Normal-weight women who gained weight were also at increased risk of new LGA in the second pregnancy (aRR 1.26, 95% CI 1.06 to 1.50 with gain of 1–3 kg/m2and aRR 1.34, 95% CI 1.09 to 1.65 with gain of ≥3 kg/m2).ConclusionsLosing weight after an LGA birth was associated with a reduced LGA risk in the next pregnancy in overweight women, while interpregnancy weight gain was associated with an increased new LGA risk. Preventing weight gain between pregnancies is an important measure to achieve better maternal and offspring outcomes.

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