scholarly journals Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine Study

2010 ◽  
Vol 69 (12) ◽  
pp. 2102-2106 ◽  
Author(s):  
Gregory Livshits ◽  
Sergey Ermakov ◽  
Maria Popham ◽  
Alex J MacGregor ◽  
Philip N Sambrook ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Degenerative Disc Disease ◽  
Large Population ◽  
Population Sample ◽  
Population Based ◽  
Mineral Density ◽  
Disc Disease ◽  
Degenerative Disc

ObjectiveOsteoarthritis (OA) and osteoporosis are often considered to lie at opposite ends of a spectrum of bone phenotypes. Lumbar degenerative disc disease (LDD) may be associated with low back pain (LBP) and is similar in many ways to OA. LDD is reported in small studies to be associated with increased spine bone mineral density (BMD). The present work aimed to confirm this association in a large population sample using MRI and explore the relationship further, in particular to determine whether it is mediated genetically.MethodsA population based sample (N=908, age range 32–74 years) of UK female twins having MRI of the lumbar spine was used in this study. LDD traits and summary measures and their relationship with BMD at the lumbar spine and hip were examined using multivariate multiple regression and maximum likelihood based variance decomposition.ResultsThere was a significant positive correlation between LDD and BMD at the lumbar spine and hip, which remained significant after adjustment for confounders. Both traits were highly heritable and the associations between them were mediated genetically.ConclusionsA clear, significant and independent association of BMD at hip and lumbar spine with LDD was found which is, in part, genetically mediated. The association with the non-axial site, the hip, is of particular interest and suggests a systemic bone effect. This should encourage the search for pleiotropic genes to help in the understanding of the bone–cartilage relationship. Moreover, genetic variants identified could provide novel therapeutic targets in the management of LBP.

The impact of degenerative disc disease on regional volumetric bone mineral density (vBMD) measured by quantitative computed tomography

2020 ◽  
Vol 20 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Ichiro Okano ◽  
Stephan N. Salzmann ◽  
Conor Jones ◽  
Courtney Ortiz Miller ◽  
Toshiyuki Shirahata ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Degenerative Disc Disease ◽  
Quantitative Computed Tomography ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Disc Disease ◽  
Degenerative Disc ◽  
The Impact

Prospective evaluation of risk of vertebral fractures using quantitative ultrasound measurements and bone mineral density in a population-based sample of postmenopausal women: results of the Basel Osteoporosis Study

2008 ◽  
Vol 68 (3) ◽  
pp. 391-396 ◽  
Author(s):  
R Hollaender ◽  
F Hartl ◽  
M-A Krieg ◽  
A Tyndall ◽  
C Geuckel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Vertebral Fracture ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Vertebral Fractures ◽  
Population Based ◽  
Mineral Density ◽  
Incident Vertebral Fracture ◽  
Incident Vertebral Fractures

Objective:Prospective studies have shown that quantitative ultrasound (QUS) techniques predict the risk of fracture of the proximal femur with similar standardised risk ratios to dual-energy x-ray absorptiometry (DXA). Few studies have investigated these devices for the prediction of vertebral fractures. The Basel Osteoporosis Study (BOS) is a population-based prospective study to assess the performance of QUS devices and DXA in predicting incident vertebral fractures.Methods:432 women aged 60–80 years were followed-up for 3 years. Incident vertebral fractures were assessed radiologically. Bone measurements using DXA (spine and hip) and QUS measurements (calcaneus and proximal phalanges) were performed. Measurements were assessed for their value in predicting incident vertebral fractures using logistic regression.Results:QUS measurements at the calcaneus and DXA measurements discriminated between women with and without incident vertebral fracture, (20% height reduction). The relative risks (RRs) for vertebral fracture, adjusted for age, were 2.3 for the Stiffness Index (SI) and 2.8 for the Quantitative Ultrasound Index (QUI) at the calcaneus and 2.0 for bone mineral density at the lumbar spine. The predictive value (AUC (95% CI)) of QUS measurements at the calcaneus remained highly significant (0.70 for SI, 0.72 for the QUI, and 0.67 for DXA at the lumbar spine) even after adjustment for other confounding variables.Conclusions:QUS of the calcaneus and bone mineral density measurements were shown to be significant predictors of incident vertebral fracture. The RRs for QUS measurements at the calcaneus are of similar magnitude as for DXA measurements.

Rates of Bone Loss in Peri- and Postmenopausal Women: A 4 Year, Prospective, Population-Based Study

1996 ◽  
Vol 91 (3) ◽  
pp. 307-312 ◽  
Author(s):  
R. Young ◽  
H. May ◽  
S. Murphy ◽  
C. Grey ◽  
J. E. Compston
Keyword(s):  
Bone Mineral Density ◽  
Hormone Replacement Therapy ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Replacement Therapy ◽  
Bone Mineral ◽  
Proximal Femur ◽  
Hormone Replacement ◽  
Population Based ◽  
Mineral Density

1. Age-related bone loss is well established but reported rates of bone loss in the spine and femur vary widely. The aim of the present study was to investigate changes in bone mineral density in the lumbar spine and proximal femur in healthy postmenopausal women. 2. One hundred and thirty-eight population-based women, aged 45–65 years, recruited from general practice registers in 1990, were assessed at baseline; 108 returned for repeat assessment 4 years later, of whom 31 had taken hormone replacement therapy for 12 months or more of the 4-year study period. Bone densitometry of the lumbar spine and proximal femur was performed by dual-energy X-ray absorptiometry. Serum 25-hydroxyvitamin D and oestradiol were measured by RIA and serum intact parathyroid hormone by radio-immunometric assay. 3. The mean age at follow-up was 62 years (mean of 13.6 years after menopause). Lumbar spine bone mineral density was significantly higher in women who had received hormone replacement therapy for more than 12 months during the study period than in those who had not (P < 0.01). There was no difference between these two groups in the femoral neck or trochanteric bone mineral density. In the lumbar spine, the annual change in bone mass in untreated women was −0.39% (95% confidence intervals −0.60 to −0.09; P < 0.02) whereas there was a small gain in women receiving hormone replacement therapy [+0.36% (−0.12 to 0.84; P not significant)]. The annual change in bone mass in the femoral neck and trochanter was −0.51 and −0.45 respectively in untreated women (P < 0.01 and P < 0.02), and −0.16 and −0.15 in those receiving hormone replacement therapy (P not significant). 4. Our results demonstrate relatively low rates of bone loss in the spine and proximal femur in these healthy, population-based peri- and postmenopausal women. Hormone replacement therapy appeared to be associated with a significant protective effect on spinal, but not femoral, bone mineral density.

Association between bone mineral density and C-reactive protein in a large population-based sample

2012 ◽  
Vol 64 (8) ◽  
pp. 2624-2631 ◽  
Author(s):  
Paola de Pablo ◽  
Mark S. Cooper ◽  
Christopher D. Buckley
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Large Population ◽  
Population Based ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

scholarly journals Osteoporoseforskning i Tromsø

2009 ◽  
Vol 5 (2) ◽  
Author(s):  
Gro K.R. Berntsen m.fl.
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Large Population ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
English Summary ◽  
Font Size ◽  
Mineral Density ◽  
Population Based Study ◽  
Access To Data

<strong><span style="font-family: TimesNewRomanPS-BoldMT;"><span style="font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p></span></span><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">SAMMENDRAG</span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">Tromsø Osteoporose Studie (TROST) er knyttet til den fjerde store befolkningsundersøkelsen som</p><p align="left">gjennomføres i Tromsø. Vår tilgang til Tromsøundersøkelsenes kartlegging av livsstilsfaktorer,</p><p align="left">risikofaktorer for hjerte-kar sykdom samt flere kliniske- og laboratoriemålinger i befolkningen gjennom de</p><p align="left">siste 20 år gjør TROST til en unik studie i verdenssammenheng. Pr 1. oktober 1995 vil vi ha undersøkt</p><p align="left">bentetthet i underarm hos ca. 8 000 personer. De fire delprosjektene som drives under TROST tar for seg</p><p align="left">bentetthet, biokjemiske markører for osteoporose, klinisk osteoporose og brudd. En nærmere presentasjon</p><p align="left">av hvert prosjekt gis i teksten.</p><p align="left">Berntsen GKR, Midtby M, Ringberg TM, Joakimsen RM, Magnus JH, Tollan A, Fønnebø V, Søgaard AJ.</p></span></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><p align="left">Research on osteoporosis in Tromsø.</p></span></span></strong></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p></span></strong></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">ENGLISH SUMMARY</span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">The Tromsø Osteoporosis Study (TROST) is part of the fourth large population based study being</p><p align="left">conducted in Tromsø, Norway. Our access to data from the current and previous Tromsø studies providing</p><p align="left">information on lifestyle factors, risk factors for cardiovascular disease, and several clinical and laboratory</p><p align="left">measurements in the population throughout the last 20 years makes TROST a unique study internationally.</p><p align="left">By October 1, 1995, we will have examined bone mineral density in the forearm of 8 000 subjects. The four</p><p align="left">research projects under TROST focus on determinants of bone mineral density, biochemical markers of</p><p align="left">osteoporosis, clinical osteoporosis and determinants of osteoporotic fractures. A presentation of each</p><p>project is given in the text.</p></span></span></strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;">Nor J Epidemiol </span></span></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">1995; </span></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">5 </span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">(2): 171-174.</span></span>

Association between reproductive factors and postmenopausal osteoporosis

2011 ◽  
Vol 20 (03) ◽  
pp. 248-251
Author(s):  
H. R. Meybodi ◽  
N. Khalili ◽  
P. Khashayar ◽  
R. Heshmat ◽  
A. Hossein-nezhad ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Reproductive Factors ◽  
Population Based ◽  
Age At Menarche ◽  
Mineral Density ◽  
Cross Sectional ◽  
Number Of Children ◽  
Menstrual History ◽  
Duration Of Breastfeeding

SummaryThe present cross-sectional research was designed to study possible correlations between clinical reproductive factors and bone mineral density (BMD) values.Using the data gathered by the population-based Iranian Multicenter Osteoporosis Study (IMOS), we investigated the correlation found between reproductive factors and osteoporosis. Subjects were recruited from five major cities of Iran. Bone mineral density was measured using Dual-Energy X-ray Absorptiometry and the results were analyzed against the age at menarche and at menopause, number of pregnancies, children and abortions, and the history (and duration) of breastfeeding.Data was available for 2528 women. Gravidity and number of children were reversely correlated with BMD. Younger age at menarche was associated with higher BMD values, whereas there was no significant correlation between age at menopause and menstrual history and BMD.Our study suggests that clinical reproductive factors, particularly number of children and breastfeeding, could be incorporated as predictors of BMD levels in women. Given the controversial results obtained in different studies, longitudinal studies should be carried out to enlighten the importance of these factors and the rationale of their use to predict BMD values in different settings.

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