scholarly journals SAPHO syndrome with enthesopathy

2019 ◽  
Vol 12 (1) ◽  
pp. e225929 ◽  
Author(s):  
Chin-Fang Su ◽  
Yu-Chuan Shen ◽  
Hsien-Tzung Liao ◽  
Chang-Youh Tsai
Keyword(s):  
Clinical Manifestations ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Sapho Syndrome ◽  
Asian Woman ◽  
Imaging Features ◽  
Middle Aged ◽  
Multifocal Osteomyelitis

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was first described as chronic recurrent multifocal osteomyelitis. Because of its rarity, a thorough description of its clinical manifestations is lacking. Herein, we describe the clinical manifestations and imaging features, especially the enthesopathy in bilateral Achilles tendons, of a middle-aged Asian woman with SAPHO syndrome, who improved after diclofenac treatment.

scholarly journals Non-bacterial osteitis: Chronic Recurrent Multifocal Osteomyelitis or pediatric SAPHO?

2020 ◽  
pp. 26-28
Keyword(s):  
Innate Immunity ◽  
Clinical Features ◽  
Bone Disease ◽  
Bone Pain ◽  
Clinical Presentation ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Sapho Syndrome ◽  
Imaging Features ◽  
Common Clinical Presentation ◽  
Multifocal Osteomyelitis

Chronic Recurrent Multifocal Osteomyelitis (CRMO) and SAPHO syndrome represent the group of autoinflammatory bone disease responsible for recurrent non-bacterial osteitis (NBO). both are considered as defects of innate immunity. The most common clinical presentation is recurrent episodes of bone pain with or without fever.The clinical and imaging features are non-specific.This usually leads to late and confusing diagnosis. We hereby report a case of CRMO in a 12-year-old patient. The aim is to highlight the confusing overlap of clinical features between CRMO and SAPHO syndromes. Keywords: multifocal osteomyelitis, non-bacterial osteitis, SAPHO, bone pain.

THE "SAPHO" SYNDROME: A CASE REPORT OF A PATIENT WITH AN ACCIDENTAL FINDING OF HYPEROSTOSIS IN PLAIN X-RAYS OF THORAX

2008 ◽  
Vol 11 (01) ◽  
pp. 29-35
Author(s):  
M. Pyrgioti ◽  
E. Mahaira ◽  
G. Papagiannakis ◽  
A. Syrou ◽  
I. H. Alexandris ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Health Status ◽  
Bone Tissue ◽  
Laboratory Tests ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Sapho Syndrome ◽  
X Rays ◽  
Multifocal Osteomyelitis ◽  
Histopathologic Findings

The authors describe the clinical, bone scintigraphy, and histopathologic findings of chronic recurrent multifocal osteomyelitis (CRMO), which is considered to be part of the SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Knowledge of this disorder may help in the differential diagnosis of arthritis, and it will help avoid repeated biopsies. We report the case of a 52-year-old man who was admitted to hospital due to an accidental finding in plain X-rays during his first check-up of his health status. He underwent laboratory tests, imaging examinations, and biopsy and histopathologic examinations of bone tissue; and was diagnosed with the SAPHO syndrome (CRMO).

SAPHO and CRMO: The Value of Imaging

2018 ◽  
Vol 22 (02) ◽  
pp. 207-224 ◽  
Author(s):  
Rikke Klicman ◽  
Paolo Simoni ◽  
Philip Robinson ◽  
James Teh ◽  
Anne Jurik
Keyword(s):  
Interdisciplinary Approach ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Imaging Features ◽  
Invasive Procedures ◽  
Palmoplantar Pustulosis ◽  
Appropriate Treatment ◽  
Pathologic Features ◽  
Skeletal Site ◽  
Characteristic Imaging ◽  
Multifocal Osteomyelitis

AbstractThe syndromes synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) constitute a group of chronic relapsing inflammatory osteoarticular disorders with frequently associated skin eruptions such as palmoplantar pustulosis and acne conglobata and rather characteristic imaging features in the form of osteitis and/or hyperostosis. CRMO predominantly occurs in children/adolescents and SAPHO in adults. Any skeletal site can be involved, and the imaging appearances vary, depending on the patient's age and the stage/age of the lesion. The diagnosis may be difficult if there is no skin disease, but attention to characteristic imaging appearances may help avoid misdiagnosis (e.g., infection and tumor) and thereby unnecessary invasive procedures as well as facilitating early diagnosis and appropriate treatment. This article provides an overview of the radiologic appearances of SAPHO/CRMO and relevant pathogenetic, clinical, and pathologic features to facilitate the diagnosis that often requires an interdisciplinary approach including radiologists.

scholarly journals Role of Diagnostic Imaging in Chronic Recurrent Multifocal Osteomyelitis (CRMO) in Children: An Observational Study

Children ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 792
Author(s):  
Michał Kopeć ◽  
Magdalena Brąszewska ◽  
Mariusz Jarosz ◽  
Katarzyna Dylewska ◽  
Andrzej Kurylak
Keyword(s):  
Observational Study ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Conventional Radiography ◽  
Cortical Layer ◽  
Mri Findings ◽  
Multifocal Osteomyelitis ◽  
Magnetic Resonance Imaging Mri

The aim of this single-center observational study was to analyze the applicability of various imaging studies to the diagnosis and further evaluation of patients with chronic recurrent multifocal osteomyelitis (CRMO). The analysis included the data of 10 patients with CRMO treated between 2016 and 2021. The mean ages of the patients at the first manifestation of CRMO and ultimate diagnosis were 10 years and 7 months and 11 years and 10 months, respectively. Conventional radiography demonstrated focal loss of bone density in only 30% of the patients. Computed tomography showed disseminated foci with non-homogeneous osteolytic/osteosclerotic structure, with a massive loss of cortical layer and strong periosteal reaction. On magnetic resonance imaging (MRI), most patients presented with multifocal hypodense areas on T1-weighted images, with the enhancement of signal on T-weighted and STIR sequences. The duration of follow-up varied between 3 months and 3 years. In 40% of the patients, both clinical symptoms and the abnormalities seen on MRI resolved completely, whereas another 50% showed partial regression of clinical and radiological manifestations. MRI findings, co-existing with characteristic clinical manifestations, play a pivotal role in establishing the ultimate diagnosis of CRMO. MRI can also be used to monitor the outcomes of treatment in CRMO patients.

Chronic recurrent multifocal osteomyelitis in children: a new, MRI-based method of quantifying inflammation in the bone

2015 ◽  
Author(s):  
Dionysios Alexandrou ◽  
Benjamin Jacobs ◽  
O'Donnell Paul ◽  
Rikin Hargunani ◽  
Ananya Guha ◽  
...  
Keyword(s):  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis
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