Thyroid-like low-grade papillary adenocarcinoma of nasopharynx

We report a 35-year-old woman with complaints of nasal obstruction and mild post-nasal drip for 6 months. She did not improve with medical treatment. Clinical examination had no positive finding. She was evaluated with a CT scan and MRI that revealed a polypoid mass lesion in nasopharynx without any adhesion to adjacent tissue. Endoscopic examination of nasopharynx revealed an exophytic nasopharyngeal mass in anterior wall of nasopharynx that complete macroscopic transnasal endoscopic resection was performed. The histopathological examination reported thyroid-like low-grade nasopharyngeal papillary adenocarcinoma that was confirmed on immunohistochemical staining. After complete macroscopic resection of the mass, patient was regularly followed-up for 6 years and there was no evidence of recurrence. This example has the educational tips of the optimal therapeutic strategies for primary nasopharyngeal adenocarcinomas with long follow-up.

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A Case of Basaloid Squamous Cell Carcinoma of Polypoid Type in the Esophagus

Case Reports in Gastroenterology ◽

10.1159/000479312 ◽

2017 ◽

Vol 11 (3) ◽

pp. 559-563

Author(s):

Ki Hun Lee ◽

Sang Jin Lee ◽

Hak Soo Kim ◽

Sung Eun Kim ◽

Soo Yong Choi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Endoscopic Examination ◽

Basaloid Squamous Cell Carcinoma ◽

Polypoid Mass ◽

Carcinoma Of The Esophagus ◽

Ivor Lewis ◽

Basaloid Squamous

Basaloid squamous cell carcinoma of the esophagus is very rare. Further, polypoid type of esophageal cancer is also rare. We have recently treated a case of basaloid squamous cell carcinoma which presented as a 1.3-cm esophageal polyp. A 48-year-old woman was referred to our hospital because of a polypoid mass at 36 cm distance from the upper incisor on endoscopic examination, and the result of the biopsy was basaloid squamous cell carcinoma. The patient underwent Ivor Lewis operation with lymph node dissection. Two basaloid squamous cell carcinomas, of 1.3 and 0.4 cm, were diagnosed in the final pathologic examination. Regular periodic follow-up showed no evidence of recurrence or metastasis in the 5-month postoperative period.

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Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review

Case Reports in Pathology ◽

10.1155/2017/2346316 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6

Author(s):

Nicolas Macagno ◽

Stéphane Fuentes ◽

Gonzague de Pinieux ◽

André Maues de Paula ◽

Sébastien Salas ◽

...

Keyword(s):

Histopathological Examination ◽

Soft Tissue Sarcomas ◽

Fish Analysis ◽

Low Grade ◽

Central Mass ◽

Divergent Differentiation ◽

Paravertebral Muscles ◽

Well Differentiated ◽

The Right

Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine. The authors present the case of a 67-year-old man with progressive history of back pain. Physical examination revealed a mass located within the right paravertebral muscles. MR and CT imaging showed a heavily ossified central mass surrounded by a peripheral fatty component. No connection with the underlying bone was detected on imagery and during surgery. After surgical resection, histopathological examination revealed a tumor harboring combined features of well-differentiated liposarcoma and low-grade osteosarcoma. Tumor cells displayed overexpression of MDM2, CDK4, and P16 by immunohistochemistry and CGH revealed amplification of 12q13-15 as the only genetic imbalance. MDM2 FISH analysis was performed but was inconclusive. The pathological, immunohistochemical, and genetic features, the differential diagnoses, and the therapeutic management of this unusual tumor are discussed. No complementary treatment was performed initially. Following first treatment, two recurrences occurred 6 and 9 years later, both displaying histological features similar to the first occurrence. Radiotherapy was started after the second recurrence. Follow-up shows no evidence of disease 11 years after initial diagnosis. This case was unusual due to the paravertebral location of the tumor and its divergent differentiation.

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Calcified Right Ventricular Fibroma in an Adult: A Case Report

10.22541/au.162281012.24531442/v1 ◽

2021 ◽

Author(s):

Huanhuan Gao ◽

Shuai Yuan ◽

Zhiqiang Hu ◽

Zhelan Zheng ◽

Shengjun Wu

Keyword(s):

Right Ventricular ◽

Histopathological Examination ◽

Tumor Resection ◽

Anterior Wall ◽

Benign Tumors ◽

Troublesome Symptom ◽

History Of ◽

The Right ◽

Operative Recovery

Background: Cardiac fibromas are rare benign tumors of the heart composed of fibroblasts and collagen. They are common among children and adolescents but are rarely present in adults. Case presentation: We here report the case of a fifty-seven-year-old man who complaining of a 2-year history of chest tightness at rest. Transthoracic echocardiography detected a severe calcified mass protruding outside the right ventricular anterior wall near the apex. The patient was referred for tumor resection. The calcified mass was determined to be a cardiac fibroma with postoperative histopathological examination. The patient experienced an unremarkable post-operative recovery and was discharged 8 days later. Subsequent follow-up has shown complete freedom from his troublesome symptom. Conclusions: Preoperative diagnosis with various imaging modalities and early surgery are the keys to improve prognosis of patients with cardiac fibromas.

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HYPERPLASTIC GASTRIC POLYPS PRESENTING WIT MASSIVE UPPER GASTRO-INTESTINAL BLEED

Journal of Nepal Medical Association ◽

10.31729/jnma.579 ◽

2004 ◽

Vol 43 (154) ◽

Author(s):

Prahlad Karki ◽

J A Ansari ◽

A Sinha ◽

S Rijal

Keyword(s):

Hyperplastic Polyp ◽

Histopathological Examination ◽

Epigastric Pain ◽

Occult Blood ◽

Anterior Wall ◽

Intestinal Bleeding ◽

Polypoid Mass ◽

Large Size ◽

Usual Site ◽

Gi Bleed

A 39 year old man presented with massive upper Gastro-intestinal (GI) Bleed of 4 days duration. There wash/o chronic epigastric pain of 6 months duration. Upper Gl Endoscopy revealed a large polypoid mass of 6cms x 5 cms in diameter on anterior wall of body. After resuscitation surgical exploration was done. Biopsyand histopathological examination revealed hyperplastic polyp. Cornual polyp of very large size (5 cm x 6cms) with presentation with massive upper gastrointestival bleeding is quite unusual. These polyp are foundin people older than 50, usual site is antrum and they usually present with occult blood loss.Key Words: Hyperplastic polyp, upper gastro-intestinal bleeding.

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Endobronchial Mucoepidermoid Carcinoma in a child

10.22541/au.161819321.12100667/v1 ◽

2021 ◽

Author(s):

Sara Fonseca ◽

Sónia Silva ◽

Adriana Magalhães ◽

Rita Lago ◽

Norberto Estevinho ◽

...

Keyword(s):

Mucoepidermoid Carcinoma ◽

Invasive Procedure ◽

Rigid Bronchoscopy ◽

Functional Improvement ◽

Low Grade ◽

Polypoid Mass ◽

Exertional Dyspnea ◽

Chronic Respiratory Insufficiency ◽

Laser Excision

Endobronchial mucoepidermoid tumors are rare neoplasms but most cases are reported in children. Due to nonspecific symptoms, diagnosis can be challenging, but early diagnosis and treatment are crucial for prognosis. We present the case of a boy, with chronic respiratory insufficiency due to bronchiolitis obliterans, that presented worsening exertional dyspnea at 12 years. Spirometry showed a frank deterioration of respiratory function and CT scan revealed an obstructive polypoid mass in the intermediate bronchus. Given the severe basal ventilatory compromise and risk associated with surgical treatment, rigid bronchoscopy and laser excision, and photocoagulation were performed, with clinical and functional improvement. The histological examination revealed a low-grade mucoepidermoid carcinoma. The option for a minimally invasive procedure requires careful follow-up due to the risk of tumor recurrence.

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Laparoscopic Distal Pancreatectomy of a Solid Pseudopapillary Tumor (SPT) Achieves Long-Term Oncologic Safety and Multiorgan Preservation

European Journal of Pediatric Surgery Reports ◽

10.1055/s-0039-1693999 ◽

2019 ◽

Vol 07 (01) ◽

pp. e58-e62

Author(s):

Ahmed ElHaddad ◽

Paolo Gasparella ◽

Christoph Castellani ◽

Georg Singer ◽

Erich Sorantin ◽

...

Keyword(s):

Distal Pancreatectomy ◽

Histopathological Examination ◽

Laparoscopic Approach ◽

Solid Pseudopapillary Tumor ◽

Low Grade ◽

Cancer Antigen 125 ◽

Pancreatic Tail ◽

Oncological Safety

AbstractThe oncological safety of a laparoscopic approach for solid pseudopapillary tumors (SPTs) of the pancreas remains a matter of debate. We present the long-term follow-up of an adolescent girl with an SPT in the pancreatic tail. A multimodality workup including magnetic resonance imaging (MRI) revealed a complex, spherical mass of 4.4 cm × 3.6 cm × 4 cm most likely located in the pancreatic tail. All routine laboratory investigations and tumor markers were within normal limits (alpha fetoprotein [AFP], cancer antigen 125 [CA125], CA 19–9, carcinoembryonic antigen [CEA], adrenocorticotropic hormone [ACTH]). Diagnostic laparoscopy was performed to verify the origin of the tumor in the pancreatic tail. In a three-port technique the tumor was mobilized of the splenic vessels until a distal pancreatectomy could be completed. Histopathological examination confirmed the complete resection of a low-grade malignant SPT. The postoperative course was unremarkable. Regular pediatric oncological follow-up examinations for 3 years, including MRI every 6 months, ruled out recurrence and confirmed preservation of splenic and pancreatic functions. While data about the technical feasibility of a laparoscopic approach to pancreatic SPT are already available, this pediatric case report adds a long-term oncological and functional success to the available literature.

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Giant Hypopharyngeal Fibrovascular Polyp: A Case Report and Review of the Relevant Literature

Case Reports in Otolaryngology ◽

10.1155/2015/670302 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Suheyl Haytoglu ◽

Birgul Tuhanioglu ◽

Abdurrahman Bozkurttan ◽

Osman Kursat Arikan

Keyword(s):

Histopathological Examination ◽

Relevant Literature ◽

Normal Mucosa ◽

Endoscopic Examination ◽

Fibrous Stroma ◽

Fibrovascular Polyp ◽

Vascular Structures ◽

One Year ◽

Progressive Dysphagia

Fibrovascular polyps occur most commonly in the cervical esophagus and are extremely rare in the hypopharynx. In this paper, we report a case of fibrovascular polyp of a 52-year-old female, who presented with progressive dysphagia and weight loss and regurgitating a mass from her mouth. By the endoscopic examination, a polyp covered by normal mucosa with a wide stalk was detected at the hypopharynx. The pedicle of the mass was identified under general anesthesia and the 13 × 3 × 2 cm mass was completely resected perorally. Histopathological examination of the tumor showed oedematous subepithelial fibrous stroma, surrounded by squamous epithelium and containing many congested vascular structures. No recurrence was detected over one year of follow-up. This case highlights the need for clinicians to be aware of this rare entity and to develop the best approach to patient management.

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Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz082 ◽

2019 ◽

Vol 152 (5) ◽

pp. 582-589 ◽

Cited By ~ 1

Author(s):

Fengbo Huang ◽

Xueping Xiang ◽

Bo Hong ◽

Jie Min ◽

Jinfan Li

Keyword(s):

Hot Spot ◽

Gene Mutations ◽

Papillary Adenocarcinoma ◽

Morphological Characterization ◽

Low Grade ◽

Ki 67 ◽

Appropriate Treatment ◽

Rule Out

Abstract Objectives Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLGNPPA) is a relatively rare nasopharyngeal tumor. We performed morphological characterization, immunohistochemical profiling, and investigated gene mutations. We also provide clinical follow-up data and brief review of the literature. Methods Immunohistochemistry was used to evaluate the expression of TTF-1, CK19, CK7, EMA, TG, Pax-8, CK5/6, S100, and Ki-67. Additionally, in situ hybridization was utilized to identify the presence of EBV. We investigated mutations in hot-spot exons of KRAS/NRAS/BRAF to rule out common mutations seen in thyroid tumors. Results Histopathologic examination of four cases identified tumors that were mainly occupied by papillary architectures. One case had a predominantly glandular structure. The tumors expressed TTF-1 and CK19, while TG and Pax-8 were negative. S100 was moderately expressed focally in three cases. Conclusions While TLLGNPPA displays a morphological resemblance to papillary thyroid carcinoma (PTC), it is vital to differentiate nasopharyngeal metastasis from PTC for appropriate treatment.

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Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology

Case Reports in Pathology ◽

10.1155/2020/3275916 ◽

2020 ◽

Vol 2020 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Rusella Mirza ◽

Nestor Dela Cruz ◽

Guillermo A. Herrera

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Mitotic Rate ◽

Papillary Adenocarcinoma ◽

Primary Adenocarcinoma ◽

Low Grade ◽

Papillary Thyroid ◽

Spindle Cells ◽

S 100

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare primary adenocarcinoma of nasopharynx. The immunohistochemical pattern of this tumor is similar to that of papillary thyroid carcinoma making this neoplasm a challenging diagnosis. A case of TL-LGNPPA with biphasic morphology is presented. The removed tumor from the nasopharynx exhibited a polypoid appearance. Microscopically, it was composed of papillary structures admixed with a few solid areas of spindle cells. The papillae were lined by columnar epithelium. Both the epithelium and the spindle cells were strongly positive for TTF-1 and CK19 and negative for CK5/6, S-100, and thyroglobulin. Cellular atypia, necrosis, and high mitotic rate were absent. Ki67 was less than 2% in the neoplastic cells. No local recurrence or distant metastasis was reported after 12 months of follow-up. Caution should be taken to differentiate TL-LGPPA from other TTF-1-positive neoplasms, especially papillary thyroid carcinoma, as the prognosis for these two tumors is entirely different.

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Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder

Healthcare ◽

10.3390/healthcare9020217 ◽

2021 ◽

Vol 9 (2) ◽

pp. 217

Author(s):

Chih-Wei Luan ◽

Chih-Cheng Chen ◽

Kam-Fai Lee ◽

Ming-Shao Tsai ◽

Yao-Te Tsai ◽

...

Keyword(s):

Organ Transplantation ◽

Lymphoproliferative Disorder ◽

Histopathological Examination ◽

Solid Organ Transplantation ◽

Low Grade ◽

Solid Organ ◽

Hematopoietic Stem ◽

Post Transplant ◽

Low Dose Radiotherapy

(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD.

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