Optic perineuritis in polyarthritis nodosa

2021 ◽  
Vol 14 (7) ◽  
pp. e237988
Author(s):  
Sijgje Maria Droger ◽  
Jan-Hein Hensen ◽  
Lucas Cornelis van Rooij
Keyword(s):  
Optic Nerve ◽  
Clinical Outcome ◽  
Neurological Examination ◽  
Outpatient Clinic ◽  
Laboratory Tests ◽  
Rapid Diagnosis ◽  
High Dose ◽  
Good Clinical Outcome ◽  
Main Symptom ◽  
Orbital Pain

A 52-year-old male patient with polyarthritis nodosa (PAN) was referred to our neurology outpatient clinic. His main symptom was paroxysmal alternating bilateral blindness. Subsequently, he developed retro-orbital pain. Neurological examination including funduscopy was normal and laboratory tests showed no relevant abnormalities. MRI orbits showed remarkable perineural thickening and contrast enhancement of the optic nerve sheaths with sparing of the central optic nerve. These findings are pathognomonic for the clinical-radiological diagnosis of optic perineuritis (OPN). The patient was treated with high-dose immunosuppressants and had a good clinical outcome. Rapid diagnosis of OPN is important because early treatment is associated with a better outcome.

scholarly journals Efficacy of Mechanical Thrombectomy using Penumbra ACETM Aspiration Catheter Compared to Stent Retriever SolitaireTM FR in Patients with Acute Ischemic Stroke

2021 ◽  
Vol 11 (4) ◽  
pp. 504
Author(s):  
Dalibor Sila ◽  
Markus Lenski ◽  
Maria Vojtková ◽  
Mustafa Elgharbawy ◽  
František Charvát ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Acute Ischemic Stroke ◽  
Clinical Outcomes ◽  
Mechanical Thrombectomy ◽  
Binary Logistic Regression ◽  
Stent Retriever ◽  
Good Clinical Outcome ◽  
Significant Difference ◽  
Aspiration Technique

Background: Mechanical thrombectomy is the standard therapy in patients with acute ischemic stroke (AIS). The primary aim of our study was to compare the procedural efficacy of the direct aspiration technique, using Penumbra ACETM aspiration catheter, and the stent retriever technique, with a SolitaireTM FR stent. Secondarily, we investigated treatment-dependent and treatment-independent factors that predict a good clinical outcome. Methods: We analyzed our series of mechanical thrombectomies using a SolitaireTM FR stent and a Penumbra ACETM catheter. The clinical and radiographic data of 76 patients were retrospectively reviewed. Using binary logistic regression, we looked for the predictors of a good clinical outcome. Results: In the Penumbra ACETM group we achieved significantly higher rates of complete vessel recanalization with lower device passage counts, shorter recanalization times, shorter procedure times and shorter fluoroscopy times (p < 0.001) compared to the SolitaireTM FR group. We observed no significant difference in good clinical outcomes (52.4% vs. 56.4%, p = 0.756). Predictors of a good clinical outcome were lower initial NIHSS scores, pial arterial collateralization on admission head CT angiography scan, shorter recanalization times and device passage counts. Conclusions: The aspiration technique using Penumbra ACETM catheter is comparable to the stent retriever technique with SolitaireTM FR regarding clinical outcomes.

scholarly journals Plasma IL-7 and IL-15 Levels Vary Greatly after Low-Intensity Conditioning and May be Associated with Clinical Outcome in Recipients of High-Dose Sirolimus GVHD Prophylaxis

2015 ◽  
Vol 21 (2) ◽  
pp. S266-S267
Author(s):  
Syed Abbas Ali ◽  
Seth M. Steinberg ◽  
Miriam Mossoba ◽  
Joseph Rimando ◽  
Scott Rowley ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
High Dose ◽  
Low Intensity ◽  
Gvhd Prophylaxis

OC-0104 high-dose rate brachytherapy in localized penile cancer: clinical outcome analysis

2021 ◽  
Vol 158 ◽  
pp. S72-S73
Author(s):  
N. Martz ◽  
Y. Bodokh ◽  
M. Gauthier ◽  
R. Schiappa ◽  
B. Thamphya ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Dose Rate ◽  
Penile Cancer ◽  
High Dose Rate ◽  
Outcome Analysis ◽  
High Dose ◽  
High Dose Rate Brachytherapy

Improving surgical reduction in radial fractures using a ‘dowel’ pinning technique in miniature and toy breed dogs

2011 ◽  
Vol 24 (01) ◽  
pp. 45-49 ◽  
Author(s):  
C. E. DeCamp ◽  
R. Rooks ◽  
J. Yu
Keyword(s):  
Clinical Outcome ◽  
Bone Healing ◽  
Medical Records ◽  
Closed Reduction ◽  
Surgical Repair ◽  
Reduction Technique ◽  
Good Clinical Outcome ◽  
Distal Radial Fractures ◽  
Radiographic Images ◽  
Small Delay

Summary Objectives: A retrospective approach was used to detail and evaluate a ‘dowel’ pinning technique in distal radial fractures in miniature and toy breed dogs. Methods: Medical records and radiographs from 2003–2009 of miniature and toy breed dog radial fractures were examined. Sixty cases were divided into two groups: 51 radial fractures repaired with a ‘dowel’ pinning and external skeletal fixation (ESF) and nine radial fractures repaired with closed reduction and ESF. Each dog was evaluated and radiographic images were obtained at presentation, postoperatively, and at 1, 2, 4, 8, and 12 weeks postoperatively. Signalment, reduction, alignment, time to clinical bone healing and ESF removal, and implant morbidity were determined for each group. Results: Radial fractures repaired with a ‘dowel’ pin and ESF had improved reduction compared to closed reduction and ESF alone (p <0.0001 as evaluated with lateral radiographs and p <0.0004 with cranial/caudal radiographs). Both surgical groups resulted in good clinical outcome with low morbidity, however it was observed that the time to clinical union and ESF removal was an average of 2.5 weeks less with closed reduction technique compared to the open reduction and ‘dowel’ pinning technique (p <0.031). Clinical Significance: Incorporating a ‘dowel’ pin to the surgical repair enhances the reduction of distal radial fractures in miniature and toy breed dogs and results in excellent clinical outcomes but causes a small delay in bone healing.

scholarly journals Lack of Neuropathological Changes in Rats Administered Tedizolid Phosphate for Nine Months

2014 ◽  
Vol 59 (1) ◽  
pp. 475-481 ◽  
Author(s):  
Michael J. Schlosser ◽  
Hiromi Hosako ◽  
Ann Radovsky ◽  
Mark T. Butt ◽  
Dragomir Draganov ◽  
...  
Keyword(s):  
Body Weight ◽  
Optic Nerve ◽  
Body Weight Gain ◽  
Maximum Tolerated Dose ◽  
High Dose ◽  
Once Daily ◽  
Clinical Observations ◽  
Activity Measures ◽  
Dose Levels ◽  
Neurobehavioral Effects

ABSTRACTTedizolid, a novel oxazolidinone antibacterial, was administered to Long Evans rats by oral gavage once daily for up to 9 months at doses near the maximum tolerated dose (MTD) to evaluate for potential neurotoxicity. Mean plasma exposures of tedizolid at the low-, medium-, and high-dose levels (7.5, 15, and 30 mg/kg of body weight/day for males; 2.5, 5, and 10 mg/kg/day for females) were similar between males and females and were 1.8-, 3.9-, and 8.0-fold greater than exposures in patients at the therapeutic dose (200 mg once daily). Evaluated endpoints included survival, clinical observations, body weight, and food consumption. At 1, 3, 6, and 9 months, ophthalmic examinations, functional observational batteries, and locomotor activity measures were conducted, brain weights/sizes were recorded, and perfusion-fixed tissues were collected from 12 rats/sex/group/time point. A detailed morphological assessment was conducted on brain, eyes, optic nerve/tract, spinal cord, peripheral nerves (includes sciatic, sural, tibial, peroneal, trigeminal), and skeletal muscle. At the end of 9 months, less body weight gain was seen in high-dose males (−6.7%) and females (−5.8%) compared with that seen in controls. There were no tedizolid-related adverse neurobehavioral effects or tedizolid-related histopathologic changes in the central/peripheral nervous systems, including the optic nerve. Results of this study indicate that tedizolid was not neurotoxic when administered long term to pigmented rats at doses near the MTD, which were up to 8-fold higher than the human therapeutic exposure.

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