scholarly journals Partial breast resection for multifocal lower quadrant breast tumour using virtual reality

2021 ◽  
Vol 14 (3) ◽  
pp. e241608
Author(s):  
Enora Laas ◽  
Mohamed El Beheiry ◽  
Jean-Baptiste Masson ◽  
Caroline Malhaire
Keyword(s):  
Breast Cancer ◽  
Virtual Reality ◽  
Breast Surgery ◽  
Breast Tumour ◽  
Oncoplastic Surgery ◽  
Breast Volume ◽  
Cancer Treatments ◽  
Lower Quadrant ◽  
Multiple Lesions ◽  
Multifocal Lesions

Oncoplastic surgery allows an increase in the number of indications for conservative breast cancer treatments. However, uncertainty as to whether it can be performed still exists in certain situations such as with multicentric or multifocal lesions, even when the breast volume can accommodate it. With the aid of a virtual reality software, DIVA, allowing the precise visualisation of tumours and breast volumes based entirely on the patient’s MRI, we report the ability to rapidly confirm and secure an indication for partial surgery of multiple lesions in a 31-year-old patient. With the described approach, the patient did not have to suffer significant disfigurement from cancerous breast surgery without compromising safety.

scholarly journals Investigation into breast cancer and partial breast reconstruction: A review

2019 ◽  
Vol 29 (2) ◽  
Author(s):  
Mohammad Reza Ebadi ◽  
Maryam Kazemi Aghdam ◽  
Zeinab Safarpour Lima ◽  
Ladan Younesi
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Breast Surgery ◽  
Oncoplastic Surgery ◽  
Partial Mastectomy ◽  
Dominant Type ◽  
Advantages And Disadvantages ◽  
Malignant Breast Tissue ◽  
Surgical Methods ◽  
Malignant Breast

Growing increasingly in South America, Africa and Asia, breast cancer is known as the dominant type of cancer in women. Different treatments are available for breast cancer, among which surgery is the most widely used, but researchers are trying to develop new strategies. One of the most prominent surgical methods is referred to as oncoplastic surgery, that helps to remove segments of malignant breast tissue. This type of surgery aims to obtain vast surgical margins, while the remaining tissue is rearranged so that the better cosmetic outcome is obtained. This review will investigate the breast cancer and then discuss partial breast reconstruction. Before outlining the procedures, the different types of partial breast reconstruction will be discussed. Finally, advantages and disadvantages will be outlined. MEDLINE database was used to conduct the search. The main terms used were ‘Conservation Breast Surgery Reconstruction’ AND ‘Oncoplastic Surgery’, ‘Partial Mastectomy Reconstruction’ AND ‘Conservative Breast Surgery Reconstruction’, ‘oncoplastic’ [All Fields], ‘breast’ AND ‘surgery’ OR ‘surgery’ operative’, ‘oncoplastic’ (‘breast’)’. The bibliographies of relevant papers were manually searched up to October 2018, but more recent voices are also included.

scholarly journals Study of serum fucose level in breast malignancy

2019 ◽  
Vol 6 (10) ◽  
pp. 3749
Author(s):  
Ashok S. Kamble ◽  
Raj Kanthawar ◽  
N. Vijayan
Keyword(s):  
Breast Cancer ◽  
Serum Level ◽  
Breast Tumour ◽  
High Serum ◽  
Old Patients ◽  
Lower Quadrant ◽  
Outer Quadrant ◽  
Breast Malignancy ◽  
Malignant Breast ◽  
Average Serum

Background: Although for advanced tumour of breast have certain obvious physical characteristics, seldom is such physical finding seen in early malignant breast tumour. Keeping all these in mind, the present study aims at estimation of serum fucose which may help in early detection of breast malignancy.Methods: The present study was carried out over a period of one and a half year. A total of 68 patients were studied. Out of these 68 cases, 32 cases were having breast malignancy. After noting details history, through examination was done according to the proforma. Investigations were carried out as shown in proforma. Estimation of serum fucose was done in all these cases. Estimation of serum fucose was also done pre-operatively and in post-operative period.Results: It is evident from this that 70% of malignant lumps were seen in upper and outer quadrant of breast, 25% lumps in lower quadrant. It is obvious that as age advances average serum fucose level in breast cancer, starts decreasing. Thus younger patients have high Serum level as compared to old patients. Rise in serum level with the progression of stage of breast cancer. There was significant reduction observed in serum fucose level after surgery (p<0.0001).Conclusions:The estimation of serum fucose level can be used to screen cases of breast malignancy though neither as a strong arbiter, nor as a distinct diagnostic test. Its use is only as an ancillary investigation which may provide collaborative evidence only.  

Modern Trends in the Breast Cancer Conserving Surgery and Oncoplastic Breast Surgery

2018 ◽  
Vol 63 (6) ◽  
pp. 51-58
Author(s):  
А. Зикиряходжаев ◽  
A. Zikiryahodjaev ◽  
М. Ермощенкова ◽  
M. Ermoshchenkova ◽  
А. Каприн ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Social Life ◽  
Breast Surgery ◽  
Malignant Tumors ◽  
Radical Resection ◽  
Oncoplastic Surgery ◽  
Disease Stage ◽  
Oncoplastic Breast Surgery ◽  
One Stage ◽  
Oncology Research

Introduction: The highest priority for modern clinical oncology is functionally-sparing and organ-conserving treatment. In Russia, breast cancer (BC), among all malignant tumors, accounted for 21.1 % of women in 2017. Oncoplastic radical resections (OPS-BCS = oncoplastic surgery – breast conserving surgery) have been widely used. This term means resection of the breast for cancer using plastic surgery to restore the shape of the breast, in most cases with one-stage correction of the contralateral breast. Purpose: It was the creation of various techniques of oncoplastic breast surgery, applicable for the appropriate localization of breast cancer and the evaluation of surgical, oncological and aesthetic results. Methods: From 2013 to 2017, in the P.A. Hertsen Moscow Oncology Research Center, organ-conserving surgery were performed in 570 patients with BC with an average age of 54.2. Stage 0 was diagnosed in 4.6 %, I – 5.9 %, IIA – 28.7 %, IIB – 6 %, IIIA – 5.1 %, IIIC – 3.3 %, IIIB – 0.2 %, IV – 0.2 %. Radical resection in the standard version was performed in 290 patients with breast cancer, oncoplastic breast surgery in various modifications – in 280. All patients after the organ-conserving surgical treatment received radiation therapy. Patients received chemotherapy, targeted therapy and hormone therapy according to the indications in depending the disease stage and the immunohistochemical type of the tumor. Results: After an urgent and planned morphological study positive margins of resection were revealed in 10 patients, which required reresection of the edges to a negative state of them in case of an urgent intraoperative response and mastectomy – in case of a planned response. Within 4 years, local recurrences were detected in 4 patients (0.7 %), which required a mastectomy with a one-stage reconstruction. In 1 patient (0.2 %), the disease progressed as metastases to the lung – in this case lobectomy and a necessary chemotherapy were conducted. Cosmetic results were defined as excellent in 70 % cases, good – 25 %, satisfactory – 5 %. Conclusion: If there are indications for organ-conserving treatment of breast cancer and the patient’s decision concerning this surgery, the patient should be offered methods of oncoplastic surgery for the prevention of psychological and emotional stress, effective rehabilitation, and a quick return to active social life.

scholarly journals Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Samia Al-Hattali ◽  
Sarah J. Vinnicombe ◽  
Nazleen Muhammad Gowdh ◽  
Andrew Evans ◽  
Sharon Armstrong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Core Biopsy ◽  
Breast Surgery ◽  
Complete Response ◽  
Breast Tumour ◽  
Nodal Metastasis ◽  
Axillary Node ◽  
Tumour Type ◽  
Axillary Node Clearance

Abstract Background In patients who have had axillary nodal metastasis diagnosed prior to neoadjuvant chemotherapy for breast cancer, there is little consensus on how to manage the axilla subsequently. The aim of this study was to explore whether a combination of breast magnetic resonance imaging (MRI) assessed response and primary tumour pathology factors could identify a subset of patients that might be spared axillary node clearance. Methods A retrospective data analysis was performed of patients with core biopsy-proven axillary nodal metastasis prior to commencement of neoadjuvant chemotherapy (NAC) who had subsequent axillary node clearance (ANC) at definitive breast surgery. Breast tumour and axillary response at MRI before, during and on completion of NAC, core biopsy tumour grade, tumour type and immunophenotype were correlated with pathological response in the breast and the number of metastatic nodes in the ANC specimens. Results Of 87 consecutive patients with MRI at baseline, interim and after neoadjuvant chemotherapy who underwent ANC at time of breast surgery, 33 (38%) had no residual macrometastatic axillary disease, 28 (32%) had 1–2 metastatic nodes and 26 (30%) had more than 2 metastatic nodes. Factors that predicted axillary nodal complete response were MRI complete response in the breast (p < 0.0001), HER2 positivity (p = 0.02) and non-lobular tumour type (p = 0.015). Conclusion MRI assessment of breast tumour response to NAC and core biopsy factors are predictive of response in axillary nodes, and can be used to guide decision making regarding appropriate axillary surgery.

scholarly journals SURGICAL TREATMENT OF BREAST CANCER: FROM THE CONCEPT OF ERADICATION TO AESTHETIC SURGERY

2018 ◽  
Vol 14 (2) ◽  
pp. 42-53 ◽  
Author(s):  
I. K. Vorotnikov ◽  
V. P. Letyagin ◽  
I. V. Vysotskaya ◽  
V. Yu. Sel’chuk ◽  
D. A. Burov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Surgical Technique ◽  
Historical Development ◽  
Breast Surgery ◽  
Aesthetic Surgery ◽  
Oncoplastic Surgery ◽  
Oncoplastic Breast Surgery

This article discusses the historical development of oncoplastic surgery, describes the main stages of oncoplastic breast surgery, indications and contraindications for it, and the algorithms for choosing an appropriate surgical technique for patients with breast cancer.

scholarly journals Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance

2017 ◽  
Vol 24 (10) ◽  
pp. R349-R366 ◽  
Author(s):  
Catherine Zabkiewicz ◽  
Jeyna Resaul ◽  
Rachel Hargest ◽  
Wen Guo Jiang ◽  
Lin Ye
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Bone Morphogenetic Proteins ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Breast Tumour ◽  
Cellular Functions ◽  
Foetal Development ◽  
Key Factor ◽  
The Right

Bone morphogenetic proteins (BMPs) belong to the TGF-β super family, and are essential for the regulation of foetal development, tissue differentiation and homeostasis and a multitude of cellular functions. Naturally, this has led to the exploration of aberrance in this highly regulated system as a key factor in tumourigenesis. Originally identified for their role in osteogenesis and bone turnover, attention has been turned to the potential role of BMPs in tumour metastases to, and progression within, the bone niche. This is particularly pertinent to breast cancer, which commonly metastasises to bone, and in which studies have revealed aberrations of both BMP expression and signalling, which correlate clinically with breast cancer progression. Ultimately a BMP profile could provide new prognostic disease markers. As the evidence suggests a role for BMPs in regulating breast tumour cellular function, in particular interactions with tumour stroma and the bone metastatic microenvironment, there may be novel therapeutic potential in targeting BMP signalling in breast cancer. This review provides an update on the current knowledge of BMP abnormalities and their implication in the development and progression of breast cancer, particularly in the disease-specific bone metastasis.

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