Percutaneous balloon pulmonary valvuloplasty in a pregnant woman with severe pulmonary valve restenosis

2021 ◽  
Vol 14 (11) ◽  
pp. e246368
Author(s):  
Dilip Johny ◽  
Kodangala Subramanyam ◽  
Sanjana Shivanand ◽  
Vishanthika Rajamony

A 34-year-old woman, a known case of valvular heart disease, post balloon pulmonary valvuloplasty done 8 years ago during her first pregnancy, presented with progressive exertional breathlessness with New York Heart Association class III symptoms in her third trimester of pregnancy. On examination, she had features of right heart failure. ECG showed right axis deviation, right ventricular hypertrophy with strain pattern. Transthoracic echocardiography showed severe pulmonary valve stenosis, right ventricular hypertrophy, right ventricular and atrial dilatation with reduced right ventricular function. As the patient was symptomatic, she underwent percutaneous balloon pulmonary valvuloplasty. The procedure was successful with a significant reduction in the pulmonary valve gradient and the patient was discharged in stable condition with reduced symptoms. The timely intervention of the valvular stenotic lesion in pregnancy reduces the mortality risk to both the mother and the fetus.

2020 ◽  
Vol 21 (17) ◽  
pp. 6421
Author(s):  
Eduardo Pena ◽  
Julio Brito ◽  
Samia El Alam ◽  
Patricia Siques

High altitude (hypobaric hypoxia) triggers several mechanisms to compensate for the decrease in oxygen bioavailability. One of them is pulmonary artery vasoconstriction and its subsequent pulmonary arterial remodeling. These changes can lead to pulmonary hypertension and the development of right ventricular hypertrophy (RVH), right heart failure (RHF) and, ultimately to death. The aim of this review is to describe the most recent molecular pathways involved in the above conditions under this type of hypobaric hypoxia, including oxidative stress, inflammation, protein kinases activation and fibrosis, and the current therapeutic approaches for these conditions. This review also includes the current knowledge of long-term chronic intermittent hypobaric hypoxia. Furthermore, this review highlights the signaling pathways related to oxidative stress (Nox-derived O2.- and H2O2), protein kinase (ERK5, p38α and PKCα) activation, inflammatory molecules (IL-1β, IL-6, TNF-α and NF-kB) and hypoxia condition (HIF-1α). On the other hand, recent therapeutic approaches have focused on abolishing hypoxia-induced RVH and RHF via attenuation of oxidative stress and inflammatory (IL-1β, MCP-1, SDF-1 and CXCR-4) pathways through phytotherapy and pharmacological trials. Nevertheless, further studies are necessary.


2011 ◽  
Vol 7 (1) ◽  
pp. 66-70
Author(s):  
Ari M. Cedars ◽  
Cylen Javidan-Nejad ◽  
Manu Goyal ◽  
Joseph Billadello ◽  
Philip Ludbrook

1992 ◽  
Vol 54 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Chia-Ming Hsieh ◽  
Gregory J. Mishkel ◽  
Paulo F.G. Cardoso ◽  
Harry Rakowski ◽  
Stephen C. Dunn ◽  
...  

2012 ◽  
Vol 58 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Mirella Pessoa Sant’Anna ◽  
Roberto José Vieira de Mello ◽  
Luciano Tavares Montenegro ◽  
Mônica Modesto Araújo

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
J Neumann ◽  
W Janssen ◽  
B Kojonazarov ◽  
C Döbele ◽  
HA Ghofrani ◽  
...  

iScience ◽  
2021 ◽  
pp. 102232
Author(s):  
Philippe Chouvarine ◽  
Joachim Photiadis ◽  
Robert Cesnjevar ◽  
Jens Scheewe ◽  
Ulrike MM. Bauer ◽  
...  

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