scholarly journals Prevalence of glaucoma in the Lao People’s Democratic Republic: the Vientiane Eye Study

2021 ◽  
pp. bjophthalmol-2020-317658
Author(s):  
Brad Guo ◽  
Yiran Tan ◽  
Stephen Nygaard ◽  
Cesar Carrillo ◽  
Kham Od Nouansavanh ◽  
...  
Keyword(s):  
Rural Areas ◽  
Democratic Republic ◽  
Open Angle Glaucoma ◽  
Population Based ◽  
Angle Closure ◽  
Lao People’S Democratic Republic ◽  
Lao People's Democratic Republic ◽  
Primary Angle Closure Glaucoma ◽  
Snellen Visual Acuity ◽  
Urban And Rural Areas

AimsTo determine the prevalence and subtypes of glaucoma in Vientiane Province.MethodsWe conducted a population-based study of 1264 participants aged ≥40 years of age from urban and rural areas of Vientiane Province. Data collection included Snellen visual acuity, slip lamp examination, tonometry, gonioscopy, dilated stereoscopic disc examination and perimetry. Glaucoma was categorised by clinical subtype.ResultsThe mean age of the 1264 participants was 57.6 years; 91.9% of eyes had a gradable disc. The prevalence of glaucoma of any category in at least one eye was 1.54% (95% CI 0.66% to 3.59%). The overall prevalence of primary open-angle glaucoma, primary angle-closure glaucoma and secondary glaucoma was 0.62% (95% CI 0.19% to 1.98%), 0.55% (95% CI 0.12% to 2.54%) and 0.37% (95% CI 0.07% to 1.86%); 12 (66.7%) of participants with glaucoma were at least unilaterally blinded by WHO definition.ConclusionsThe prevalence of glaucoma in the Vientiane Eye Study is relatively low compared with the prevalence reported in other studies from Asian regions; however, the median age in this study was low, reflecting the age group of the population and the rapid urbanisation occurring in the Lao People’s Democratic Republic. Nevertheless, glaucoma remains a blinding disease in this population.

Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma

2021 ◽  
pp. 112067212110425
Author(s):  
Altaf A Kondkar ◽  
Tahira Sultan ◽  
Abdullah S Alobaidan ◽  
Taif A Azad ◽  
Essam A Osman ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Statistical Tests ◽  
Population Based ◽  
Angle Closure ◽  
Allelic Association ◽  
Pseudoexfoliation Glaucoma ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Genome Wide ◽  
Clinical Indices

Objective: Previous genome-wide studies have demonstrated significant pathogenic association between variants rs35934224 within TXNRD2 and rs6478746 near LMX1B in primary open-angle glaucoma. We investigated the association between these variants in primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) patients of Saudi origin. Methods: In a case-control study, DNA samples from 249 controls (135 men and 114 women), 100 PACG cases (44 men and 56 women), and 95 PXG cases (61 men and 34 women) were genotyped by TaqMan® based real-time PCR. Statistical tests were performed to evaluate genetic association with glaucoma types and related clinical indices. Results: The allele frequencies of rs35934224 and rs6478746 did not show significant variation in PACG and PXG than controls, except that the rs35934224[T] allele was found to be significantly low among PXG women (0.10) as compared to controls (0.21) (odds ratio = 0.38, 95% confidence interval = 0.16–0.94, p = 0.024). Rs35934224 genotypes showed a nominal-to-borderline protective association with PACG and PXG among women in different genetic models. However, except for the over-dominant model in PACG ( p = 0.0095), none of the effects survived Bonferroni’s correction ( p < 0.01). Rs6478746 showed no significant genotype or allelic association with PACG and PXG. Regression analysis showed no influence on disease outcome, and neither showed any correlation with intraocular pressure and cup/disk ratio in both PACG and PXG. Conclusions: Variants rs35934224 in TXNRD2 and rs6478746 near LMX1B are not associated with PACG and PXG in the Saudi cohort, but rs35934224 may confer modest protection among women. Further population-based studies are needed to validate these results.

scholarly journals Risk of Glaucoma Associated with Components of Metabolic Disease in Taiwan: A Nationwide Population-Based Study

2021 ◽  
Vol 19 (1) ◽  
pp. 305
Author(s):  
Ya-Wen Chang ◽  
Fung-Chang Sung ◽  
Ya-Ling Tzeng ◽  
Chih-Hsin Mou ◽  
Peng-Tai Tien ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Open Angle Glaucoma ◽  
Population Based ◽  
Incidence Rates ◽  
Angle Closure ◽  
Health Providers ◽  
Population Based Study ◽  
Primary Angle Closure Glaucoma ◽  
Patients With Diabetes ◽  
Insurance Claims Data

Purpose: This retrospective cohort study was conducted to determine the glaucoma risk associated with metabolic disease (MetD) using insurance claims data of Taiwan. Methods: From the database, we identified patients with newly diagnosed hypertension, diabetes and/or hyperlipidemia from the years 2000 to 2002 as the MetD cohort (N = 42,036) and an age-gender-diagnosis-date matched control cohort without MetD with a two-fold sample size than that of the MetD cohort. Both cohorts were followed until the development of glaucoma, death, or withdrawal, until December 31, 2013. The incidence of glaucoma, and the Cox method estimated hazard ratio (HR) of glaucoma were calculated. Results showed that the incidence of glaucoma was two-fold higher in the MetD cohort than in the controls (1.99 versus 0.99 per 1000 person-years), with an adjusted HR of 1.66 (95% CI: 1.50–1.85). The glaucoma incidence was higher in patients with diabetes than those with hypertension and hyperlipidemia (2.38 versus 1.95 and 1.72 per 1000 person-years, respectively). The incidence increased to 5.67 per 1000 person-years in patients with all three comorbidities, with an aHR of 4.95 (95% CI: 2.35–10.40). We also found higher incidence rates of primary open-angle glaucoma and primary angle-closure glaucoma with aHRs of 2.03 and 1.44, respectively. It was concluded that glaucoma risk increased with the number of MetD. Health providers need to monitor patients with MetD to prevent glaucoma.

Sign in / Sign up

Export Citation Format

Share Document