Efficacy of foot orthoses for the treatment of plantar heel pain: a systematic review and meta-analysis

BackgroundPlantar heel pain (PHP) is common. Foot orthoses are often applied as treatment for PHP, even though there is little evidence to support this.ObjectiveTo investigate the effects of different orthoses on pain, function and self-reported recovery in patients with PHP and compare them with other conservative interventions.DesignSystematic review and meta-analysis.Data sourcesA systematic literature search was conducted in MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL and Google Scholar up to January 2017.Eligibility criteria for selecting studiesRandomised controlled trials comparing foot orthoses with a control (defined as no intervention, sham or other type of conservative treatment) reporting on pain, function or self-reported recovery in patients with PHP.ResultsTwenty studies investigating eight different types of foot orthoses were included in the review. Most studies were of high quality. Pooled data from six studies showed no difference between prefabricated orthoses and sham orthoses for pain at short term (mean difference (MD) of 0.26 (95% CI −0.09 to 0.60)). No difference was found between sham orthoses and custom orthoses for pain at short term (MD 0.22 (95% CI −0.05 to 0.50)), nor was there a difference between prefabricated orthoses and custom orthoses for pain at short term (MD 0.03 (95% CI −0.15 to 0.22)). For the majority of other interventions, no significant differences were found.ConclusionsFoot orthoses are not superior for improving pain and function compared with sham or other conservative treatment in patients with PHP.PROSPERO registration numberCRD42015029659.

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The Effectiveness of Combined Shockwave Therapy and Exercise for Plantar Heel Pain: A Systematic Review Protocol

10.31236/osf.io/uezfw ◽

2020 ◽

Author(s):

Ian Burton

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Heel Pain ◽

Controlled Trials ◽

Cochrane Central Register ◽

Systematic Review Methodology ◽

Treatment Protocols ◽

Shockwave Therapy ◽

Plantar Heel Pain ◽

Wide Range

Review Objective: To synthesize the best available evidence on the effectiveness of interventions that have used a combination of extracorporeal shockwave therapy and any type of exercise to treat plantar heel pain compared to any other treatment intervention. Introduction: Recent evidence suggests combining shockwave therapy and exercise may be more effective than other treatments for plantar heel pain. However, no systematic reviews have been conducted on the topic and optimal treatment protocols and clinical recommendations are lacking.Inclusion criteria: Randomised controlled trials assessing the effectiveness of combined shockwave therapy and exercise for plantar heel pain in adults will be included. Methods: The authors will search for a wide range of sources to find both published and unpublished studies via EBSCOhost, including, but not limited to, MEDLINE, SPORTDiscus, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), and Allied and Complementary Medicine Database (AMED). Studies published in a language other than English will only be considered if a translation is available. The JBI systematic review methodology will be followed when conducting the review. Data synthesis will be conducted using meta-analysis or narrative synthesis, where appropriate. Systematic review registration number: CRD42020213286

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Foot orthoses for plantar heel pain: a systematic review and meta-analysis

British Journal of Sports Medicine ◽

10.1136/bjsports-2016-097355 ◽

2017 ◽

Vol 52 (5) ◽

pp. 322-328 ◽

Cited By ~ 31

Author(s):

Glen A Whittaker ◽

Shannon E Munteanu ◽

Hylton B Menz ◽

Jade M Tan ◽

Chantel L Rabusin ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Heel Pain ◽

Cochrane Library ◽

Foot Orthoses ◽

Medium Term ◽

Eligibility Criteria ◽

Plantar Heel Pain ◽

Moderate Quality ◽

Quality Evidence

ObjectiveTo investigate the effectiveness of foot orthoses for pain and function in adults with plantar heel pain.DesignSystematic review and meta-analysis. The primary outcome was pain or function categorised by duration of follow-up as short (0 to 6 weeks), medium (7 to 12 weeks) or longer term (13 to 52 weeks).Data sourcesMedline, CINAHL, SPORTDiscus, Embase and the Cochrane Library from inception to June 2017.Eligibility criteria for selecting studiesStudies must have used a randomised parallel-group design and evaluated foot orthoses for plantar heel pain. At least one outcome measure for pain or function must have been reported.ResultsA total of 19 trials (1660 participants) were included. In the short term, there was very low-quality evidence that foot orthoses do not reduce pain or improve function. In the medium term, there was moderate-quality evidence that foot orthoses were more effective than sham foot orthoses at reducing pain (standardised mean difference −0.27 (−0.48 to −0.06)). There was no improvement in function in the medium term. In the longer term, there was very low-quality evidence that foot orthoses do not reduce pain or improve function. A comparison of customised and prefabricated foot orthoses showed no difference at any time point.ConclusionThere is moderate-quality evidence that foot orthoses are effective at reducing pain in the medium term, however it is uncertain whether this is a clinically important change.

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Effect of Premorbid Beta-Blockers on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis

Journal of Intensive Care Medicine ◽

10.1177/08850666211052926 ◽

2021 ◽

pp. 088506662110529

Author(s):

Daisuke Hasegawa ◽

Ryota Sato ◽

Narut Prasitlumkum ◽

Kazuki Nishida

Keyword(s):

Systematic Review ◽

Beta Blockers ◽

Data Extraction ◽

Meta Analysis ◽

Controlled Trials ◽

Cochrane Central Register ◽

Short Term ◽

Cross Sectional ◽

Short Term Mortality ◽

The Impact

Objective The aim of this study was to conduct a systematic review and meta-analysis to investigate the impact of premorbid beta-blockers on mortality in patients with sepsis. Data Sources We searched EMBASE, the Cochrane Central Register of Controlled Trials, and MEDLINE for eligible studies. The protocol was registered at the PROSPERO (CRD42021256813). Study Selection Two authors independently evaluated the following inclusion criteria: (1) randomized controlled trials, cohort studies, cross-sectional studies; (2) patients with sepsis aged ≥18 years, and (3) premorbid beta-blocker use. Data Extraction Two authors extracted the patients’ characteristics and outcomes independently. All analyses were performed using the random-effects models. The primary outcome was short-term mortality, defined as mortality within 30 days, in-hospital or intensive care unit mortality. Data Synthesis Ten studies (n = 24 748 patients) were included. The pooled odds ratio (OR) of short-term mortality associated with the premorbid use of beta-blockers was 0.85 (95% confidence interval [CI], 0.69-1.04; P = .12; I2 = 50%). Five studies reported an adjusted OR of short-term mortality. The pooled adjusted OR of short-term mortality associated with the premorbid use of beta-blockers was 0.73 (95% CI, 0.65-0.83; P < .001; I2 = 0%). Conclusion Premorbid beta-blockers were associated with a lower short-term mortality in patients with sepsis.

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Platelet-Rich Fibrin in Third Molar Surgery: Systematic Review and Meta-Analysis Protocol

Craniomaxillofacial Trauma & Reconstruction ◽

10.1177/19433875211016203 ◽

2021 ◽

pp. 194338752110162

Author(s):

Gaston A. Salas ◽

Shuheng A. Lai ◽

Francisca Verdugo-Paiva ◽

Roberto A. Requena

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Grey Literature ◽

Third Molar ◽

Risk Of Bias ◽

Third Molar Surgery ◽

Controlled Trials ◽

Cochrane Central Register ◽

Eligibility Criteria ◽

Platelet Rich Fibrin

Objective: The objective of this systematic review is to assess the effectiveness and safety of platelet-rich fibrin (PRF) in third molar surgery. Data Sources: A comprehensive search strategy is meant to be used in an attempt to identify all relevant randomized controlled trials (RCTs), ongoing investigation reported in specialty congresses and trials regardless of language or publication status (published, unpublished, in press and in progress). Searches will be conducted in the Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, Embase, Lilacs, the International Clinical Trials Registry Platform (ICTRP), ClinicalTrials.gov , US National Institutes of Health (NIH), grey literature and in specialized congresses and conferences. Eligibility Criteria: We will include randomized trials evaluating the effect of PRF on wound healing after third molar surgery. Two reviewers will independently screen each study for eligibility, data extraction and risk of bias assessment using Cochrane “risk of bias” tool. We will pool the results using meta-analysis and will apply the GRADE system to assess the certainty of the evidence for each outcome. Ethics and Dissemination: As researchers will not access information that could lead to the identification of an individual participant, obtaining ethical approval was waived.

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Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysis

Archives of Disease in Childhood ◽

10.1136/archdischild-2018-316385 ◽

2019 ◽

pp. archdischild-2018-316385 ◽

Cited By ~ 1

Author(s):

Ivan D Florez ◽

Javier M Sierra ◽

Laura F Niño-Serna

Keyword(s):

Systematic Review ◽

Adverse Events ◽

Meta Analysis ◽

Grey Literature ◽

Acute Diarrhoea ◽

Stool Frequency ◽

Controlled Trials ◽

Cochrane Central Register ◽

Eligibility Criteria ◽

Randomised Controlled

ObjectiveTo determine the effectiveness and safety of gelatin tannate (GT) for reducing the duration of the acute diarrhoea and gastroenteritis (ADG) in children.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, LILACS and grey literature, published from inception to October 2018. No language restrictions.Eligibility criteria for selecting studiesRandomised controlled trials in children with ADG, comparing GT with placebo.ResultsOf 797 titles identified, we included three studies (276 children). We performed a random effects model meta-analysis for the main outcome (diarrhoea duration). We did not find significant differences between GT and placebo for diarrhoea duration (mean difference (MD)=−15.85 hours; 95% CI −42.24 to 14.82, I2=92%; three studies), stool frequency at day 2 (MD=0.11 stools/day; 95% CI −0.39 to 0.62: I2=26%; two studies), diarrhoea at day 3 (risk ratio [RR]=0.46; 95% CI 0.06 to 3.47: I2=73%; two studies), vomiting (RR=1.31; 95% CI 0.95 to 1.80: I2=0%; two studies) or adverse events (RR=0.86; 95% CI 0.27 to 2.66: I2=0%; two studies). Most common adverse events included abdominal pain and nausea.ConclusionThe effect of GT was no different to placebo for mean diarrhoea duration (low certainty on the evidence) and stool frequency at day 2 (high certainty) and for the presence of diarrhoea at day 3 (very low certainty) of vomiting (moderate certainty) and of adverse events (low certainty).PROSPERO registration numberCRD42018087902.

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Effectiveness of online interventions in preventing depression: a protocol for systematic review and meta-analysis of randomised controlled trials

BMJ Open ◽

10.1136/bmjopen-2018-022012 ◽

2018 ◽

Vol 8 (11) ◽

pp. e022012 ◽

Cited By ~ 1

Author(s):

Alina Rigabert ◽

Emma Motrico ◽

Patricia Moreno-Peral ◽

Davinia M Resurrección ◽

Sonia Conejo-Cerón ◽

...

Keyword(s):

Systematic Review ◽

Randomised Controlled Trials ◽

Meta Analysis ◽

Random Effect ◽

Psychosocial Interventions ◽

Controlled Trials ◽

Cochrane Central Register ◽

Online Interventions ◽

Eligibility Criteria ◽

Randomised Controlled

IntroductionAlthough evidence exists for the efficacy of psychosocial interventions in preventing depression, little is known about its prevention through online interventions. The objective of this study is to conduct a systematic review and meta-analysis of randomised controlled trials assessing the effectiveness of online interventions in preventing depression in heterogeneous populations.Methods and analysisWe will conduct a systematic review and meta-analysis of randomised controlled trials that will be identified through searches of PubMed, PsycINFO, WOS, Scopus, OpenGrey, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Australia New Zealand Clinical Trials Register . We will also search the reference lists provided in relevant studies and reviews. Experts in the field will be contacted to obtain more references. Two independent reviewers will assess the eligibility criteria of all articles, extract data and determine their risk of bias (Cochrane Collaboration Tool). Baseline depression will be required to have been discarded through standardised interviews or validated self-reports with standard cut-off points. The outcomes will be the incidence of new cases of depression and/or the reduction of depressive symptoms as measured by validated instruments. Pooled standardised mean differences will be calculated using random-effect models. Heterogeneity and publication bias will be estimated. Predefined sensitivity and subgroup analyses will be performed. If heterogeneity is relevant, random-effect meta-regression will be performed.Ethics and disseminationThe results will be disseminated through peer-reviewed publication and will be presented at a professional conference. Ethical assessment is not required as we will search and assess existing sources of literature.Trial registration numberCRD42014014804; Results.

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Hyaluronic acid for tissue and bone regeneration after tooth extraction. Systematic review and meta-analysis

10.1101/2020.06.02.20120733 ◽

2020 ◽

Author(s):

Shuheng Lai ◽

Francisco Novillo ◽

Geovanna Cárdenas ◽

Francisca Verdugo ◽

Gabriel Rada

Keyword(s):

Systematic Review ◽

Hyaluronic Acid ◽

Bone Regeneration ◽

Tooth Extraction ◽

Data Extraction ◽

Meta Analysis ◽

Grey Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

Eligibility Criteria

AbstractObjectiveThe objective of this systematic review is to assess the effectiveness and safety of Hyaluronic Acid (HA) on tissue and bone regeneration after tooth extraction.Data SourcesWe will conduct a comprehensive search in Epistemonikos, PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), LILACS, the International Clinical Trials Registry Platform (ICTRP), ClinicalTrials.gov, US National Institutes of Health (NIH) and grey literature, to identify all relevant randomized controlled trials regardless of language or publication status (published, unpublished, in press and in progress).Eligibility Criteria for Selecting Studies and MethodsWe will include randomized trials evaluating the effect of HA on tissue and bone regeneration after tooth extraction. Two reviewers will independently screen each study for eligibility, data extraction, and assess the risk of bias. We will pool the results using meta-analysis and will apply the GRADE system to assess the certainty of the evidence for each outcome.Ethics and DisseminationNo ethics approval is considered necessary. The results of this review will be disseminated via peer-reviewed publications, social networks, and traditional media.PROSPERO Registration IDCRD42020150285

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Comparative effectiveness of treatment options for plantar heel pain: a systematic review with network meta-analysis

British Journal of Sports Medicine ◽

10.1136/bjsports-2017-098998 ◽

2018 ◽

Vol 53 (3) ◽

pp. 182-194 ◽

Cited By ~ 19

Author(s):

Opeyemi O Babatunde ◽

Amardeep Legha ◽

Chris Littlewood ◽

Linda S Chesterton ◽

Martin J Thomas ◽

...

Keyword(s):

Systematic Review ◽

Comparative Effectiveness ◽

Meta Analysis ◽

Treatment Options ◽

Heel Pain ◽

Medium Term ◽

Sham Control ◽

Short Term ◽

Plantar Heel Pain

ObjectiveTo evaluate the comparative effectiveness of current treatment options for plantar heel pain (PHP).DesignSystematic review and network meta-analysis (NMA).Data sourcesMedline, EMBASE, CINAHL, AMED, PEDro, Cochrane Database, Web of Science and WHO Clinical Trials Platform were searched from their inception until January 2018.Study selectionRandomised controlled trials (RCTs) of adults with PHP investigating common treatments (ie, corticosteroid injection, non-steroidal anti-inflammatory drugs, therapeutic exercise, orthoses and/or extracorporeal shockwave therapy (ESWT)) compared with each other or a no treatment, placebo/sham control.Data extraction and analysisData were extracted and checked for accuracy and completeness by pairs of reviewers. Primary outcomes were pain and function. Comparative treatment effects were analysed by random effects NMA in the short term, medium term and long term. Relative ranking of treatments was assessed by surface under the cumulative ranking probabilities (0–100 scale).ResultsThirty-one RCTs (total n=2450 patients) were included. There was no evidence of inconsistency detected between direct and indirect treatment comparisons in the networks, but sparse data led to frequently wide CIs. Available evidence does not suggest that any of the commonly used treatments for the management of PHP are better than any other, although corticosteroid injections, alone or in combination with exercise, and ESWT were ranked most likely to be effective for the management of short-term, medium-term and long-term pain or function; placebo/sham/control appeared least likely to be effective; and exercise appeared to only be beneficial for long-term pain or function.ConclusionsCurrent evidence is equivocal regarding which treatment is the most effective for the management of PHP. Given limited understanding of long-term effects, there is need for large, methodologically robust multicentre RCTs investigating and directly comparing commonly used treatments for the management of PHP.PROSPERO registration numberCRD42016046963.

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Oxymetazoline for the treatment of rosacea-associated persistent facial erythema. Systematic review and meta-analysis protocol

10.1101/2020.05.25.20111344 ◽

2020 ◽

Author(s):

Geovanna Cárdenas ◽

Francisco Novillo ◽

Shuheng Lai ◽

Héctor Fuenzalida ◽

Francisca Verdugo ◽

...

Keyword(s):

Systematic Review ◽

Data Extraction ◽

Meta Analysis ◽

Grey Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

Eligibility Criteria ◽

Facial Erythema ◽

Central Register ◽

The Impact

ABSTRACTObjectiveThe objective of this systematic review is to assess the impact of oxymetazoline in patients with moderate to severe rosacea.Data SourcesWe will conduct a comprehensive search in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Lilacs, the International Clinical Trials Registry Platform (ICTRP), ClinicalTrials.gov, US National Institutes of Health (NIH) and grey literature, to identify all relevant randomized controlled trials regardless of language or publication status (published, unpublished, in press and in progress).Eligibility criteria for selecting studies and methodsWe will include randomized trials evaluating the effect of oxymetazoline in patients with moderate to severe rosacea. Two reviewers will independently screen each study for eligibility, data extraction, and assess the risk of bias. We will pool the results using meta-analysis and will apply the GRADE [1] system to assess the certainty of the evidence for each outcome.Ethics and DisseminationNo ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.Protocol and RegistrationThis protocol was adapted to the specificities of the question assessed in this review and registered to PROSPERO with the ID CRD42020150262.

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