Association of serum magnesium level change with in-hospital mortality

2020 ◽  
Vol 25 (6) ◽  
pp. 206-212 ◽  
Author(s):  
Charat Thongprayoon ◽  
Wisit Cheungpasitporn ◽  
Panupong Hansrivijit ◽  
Sorkko Thirunavukkarasu ◽  
Api Chewcharat ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Reference Group ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Absolute Difference ◽  
Serum Magnesium Level ◽  
Level Change ◽  
Median Serum ◽  
Hospitalised Patients ◽  
Group A

The objective of this study was to assess the association of in-hospital mortality risk based on change in serum magnesium levels in hospitalised patients. All adult patients admitted to our hospital from years 2009 to 2013 with at least two serum magnesium measurements during hospitalisation were included. Serum magnesium change, defined as the absolute difference between the highest and lowest serum magnesium, was categorised into six groups: 0–0.2, 0.3–0.4, 0.5–0.6, 0.7–0.8, 0.9–1.0, ≥1.1 mg/dL. In-hospital mortality was the outcome of interest. Logistic regression was used to assess the association between serum magnesium change and in-hospital mortality, using serum magnesium change of 0.0–0.2 mg/dL as the reference group. A total of 42 141 patients, with the median serum magnesium change during hospital stay of 0.3 (IQR 0.2–0.6) mg/dL, were studied. In-hospital mortality based on serum magnesium change of 0–0.2, 0.3–0.4, 0.5–0.6, 0.7–0.8, 0.9–1.0, ≥1.1 mg/dL was 1.3%, 2.3%, 3.1%, 5.0%, 6.5%, and 8.8%, respectively (p<0.001). After adjustment for potential confounders, increased serum magnesium change was significantly associated with higher in-hospital mortality with adjusted OR of 1.39 (95% 1.14–1.69) in serum magnesium change of 0.3–0.4, 1.48 (95% CI 1.21 to 1.81) in 0.5–0.6, 1.89 (95% CI 1.53 to 2.34) in 0.7–0.8, 1.85 (95% CI 1.45 to 2.37) in 0.9–1.0 and 1.89 (95% CI 1.48 to 2.41) in ≥1.1 mg/dL when compared with serum magnesium change group of 0–0.2 mg/dL. Increased in-hospital mortality was associated with both downward and upward trends of serum magnesium change during hospitalisation. The greater extent of change in serum magnesium levels was progressively associated with increased in-hospital mortality

scholarly journals High-Normal Serum Magnesium and Hypermagnesemia Are Associated With Increased 30-Day In-Hospital Mortality: A Retrospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Liao Tan ◽  
Qian Xu ◽  
Chan Li ◽  
Jie Liu ◽  
Ruizheng Shi
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Cox Regression ◽  
Serum Magnesium ◽  
Normal Serum ◽  
Magnesium Level ◽  
Serum Magnesium Level

Background: Magnesium, the fourth most abundant mineral nutrient in our body, plays a critical role in regulating ion channels and energy generation, intracardiac conduction, and myocardial contraction. In this study, we assessed the association of admission serum magnesium level with all-cause in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).Methods: Clinical data were extracted from the eICU Collaborative Research Database (eICU-CRD). Only the data for the first intensive care unit (ICU) admission of each patient were used, and baseline data were extracted within 24 h after ICU admission. Logistic regression, Cox regression, and subgroup analyses were conducted to determine the relationship between admission serum magnesium level and 30-day in-hospital mortality in ICU patients with AMI.Results: A total of 9,005 eligible patients were included. In the logistic regression analysis, serum magnesium at 2.2 to ≤2.4 and &gt;2.4 mg/dl levels were both significant predictors of all-cause in-hospital mortality in AMI patients. Moreover, serum magnesium of 2.2 to ≤2.4 mg/dl showed higher risk of in-hospital mortality than magnesium of &gt;2.4 mg/dl (adjusted odds ratio, 1.63 vs. 1.39). The Cox regression analysis yielded similar results (adjusted hazard ratio, 1.36 vs. 1.25).Conclusions: High-normal serum magnesium and hypermagnesemia may be useful and easier predictors for 30-day in-hospital mortality in critically ill patients with AMI.

scholarly journals Association of low Serum Magnesium level with occurrence of Ventricular Arrhythmia in patients with Acute Myocardial Infarction

2020 ◽  
Vol 35 (1) ◽  
pp. 39-46
Author(s):  
Nizam Uddin ◽  
Abdul Wadud Chowdhury ◽  
Mohsin Ahmed ◽  
Md Khalequzzaman ◽  
Gaffer Amin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ventricular Arrhythmia ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Mortality And Morbidity ◽  
Group A ◽  
Group B ◽  
Plasma Magnesium

Background: Acute Myocardial Infarction is the leading cause of morbidity and mortality throughout the world. Its prevalence among developing countries has increased significantly over the past two decades. Acute myocardial infarction is associated with electrolyte imbalance most commonly hypomagnesemia and hypokalaemia. Both are associated with ventricular arrhythmia which can lead to increase hospital mortality and morbidity. Objectives: To find out association of hypomagnesemia with ventricular arrhythmia in patients with acute myocardial infarction. Methods: Patients with acute myocardial infarction admitted in the department of Cardiology, DMCH, within the study period and who fulfilled the inclusion and exclusion criteria were taken as study sample. Informed consent was taken from all patients and then the patients were evaluated by detailed history, clinical examination and relevant investigations. Serum magnesium level was measured after admission. The sample population was Grouped into Group A(Acute myocardial infarction with normal serum magnesium) and Group B(Acute myocardial infarction with hypomagnesemia). Patients were followed up regularly till discharge or death for evidence of ventricular arrhythmia. Then the obtained data was analysed with SPSS 22.0. Results: Among 110 patients of Acute MI, 44 patients were in Group A who had plasma magnesium level e”0.7 mmol/ l and 66 patients were in Group B who had plasma magnesium level <0.7 mmol/l. Incidence of hypoagnesemia was 60% and more common in male. Male vs female percentage of hypomagnesemia were 61% vs 39%. Mean age was 54.16±11.72 yrs vs 57.52±10.59 yrs in group A vs group B. On admission serum magnesium level was 0.9218 vs 0.523 mmol/L( group A vs group B). The study showed that group B patients were more haemodynamically unstable and mean SBP and DBP were found 89.39±19.93 and 60.67±11.56 mm-Hg respectively. Troponin I was markedly increased in group B than A (i.e 4.7±1.79 vs 14.6±4.3 vs ng/ml). Adverse cardiac events such as cardiogenic shock (group A vs group B = 11.36% vs 28.27%) and ventricular arrhythmias(group A vs group B = 34% vs 72.73%) were also higher in group B than group A. Mean hospital stay for group B patient was higher than group A(6.78±0.85 vs 5.31±0.35 days). The study result showed that ventricular arrhythmia is negatively correlated with serum magnesium and the correlation coefficient was - 0.541. It also showed that serum Magnesium is positively correlated with Potassium(r= 0.831, p<0.01) and Calcium(r= 0.902, p<0.001). Multiple logistic regression analysis showed that hypomagnesemia is an independent risk factor for ventricular arrhythmia. Conclusions: This study showed that in patients with acute myocardial infarction, hypomagnesemia is common and it is significantly associated with ventricular arrhythmia. So the presence of hypomagnesemia should alert the physicians to adopt corrective measures as it increases both mortality and morbidity. Bangladesh Heart Journal 2020; 35(1) : 39-46

scholarly journals Association of serum chloride level alterations with in-hospital mortality

2020 ◽  
pp. postgradmedj-2019-137270 ◽  
Author(s):  
Charat Thongprayoon ◽  
Wisit Cheungpasitporn ◽  
Panupong Hansrivijit ◽  
Sorkko Thirunavukkarasu ◽  
Api Chewcharat ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Hospital Mortality ◽  
Reference Group ◽  
Downward Trend ◽  
Absolute Difference ◽  
Upward Trend ◽  
Chloride Level ◽  
Serum Chloride ◽  
Median Serum ◽  
Independent Association

BackgroundWe aimed to assess the association between alterations in serum chloride levels during hospitalisation and mortality.MethodsWe reviewed all adult patients admitted to our hospital from the year 2009 to 2013, who had at least two serum chloride measurements during hospitalisation. The serum chloride change during hospitalisation, defined as the absolute difference between the highest and lowest serum chloride levels, was categorised into seven groups; 0–2, 3–4, 5–6, 7–8, 9–10, 11–12 and ≥13 mEq/L. Multivariable logistic regression was performed to assess the independent association between serum chloride change and in-hospital mortality, using the serum chloride change of 0–2 mEq/L as the reference group.ResultsA total of 57 880 patients, with median serum chloride change of 5 (IQR 3–9) mEq/L, were studied. The in-hospital mortality was progressively increased with larger chloride change, from 0.6% in group of 0–2 mEq/L to 5.9% in group of ≥13 mEq/L (p<0.001). In adjusted analysis, serum chloride change of ≥7 mEq/L was significantly associated with increased in-hospital mortality. For upward trend, serum chloride change of ≥3 mEq/L was significantly associated with increased in-hospital mortality, whereas, for downward trend, serum chloride change was not consistently associated with in-hospital mortality.ConclusionAlterations in serum chloride during hospitalisation were associated with increased hospital mortality. The association was more prominent with upward than downward trend of serum chloride.

scholarly journals Serum Magnesium Level Change in Type 2 Diabetic Patients with Cardiovascular Complications

2019 ◽  
Vol 87 (9) ◽  
pp. 3137-3145
Author(s):  
MOHAMMED ELGAZZAR, M.Sc.; ABD ELMOTTALEB TAHA EISSA, M.D. ◽  
AMAL SAID ALBENDARY, M.D.; YASSER MOHAMED ABDELRAOUF, M.D.
Keyword(s):  
Serum Magnesium ◽  
Cardiovascular Complications ◽  
Magnesium Level ◽  
Diabetic Patients ◽  
Serum Magnesium Level ◽  
Type 2 Diabetic Patients ◽  
Level Change ◽  
Type 2 Diabetic

scholarly journals The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

2019 ◽  
Vol 8 (9) ◽  
pp. 3543
Author(s):  
Shifali Anand ◽  
Jyoti Hak ◽  
Niveditaa Prashar ◽  
Nikita Gandotra ◽  
Rohini Jaggi
Keyword(s):  
Pregnant Women ◽  
Preterm Labour ◽  
Serum Magnesium ◽  
Maternal Serum ◽  
Magnesium Level ◽  
Cervical Dilatation ◽  
Care Hospital ◽  
Serum Magnesium Level ◽  
Group A ◽  
Low Serum

Background: Serum magnesium level in pregnancy is a valuable tool to find out preterm onset of labour. In the asymptomatic group, greater surveillance and administration of steroids, tocolytics and transfer to a higher centre wherever necessary has to be done with mothers with low serum magnesium level. The objective of the study is to find association between serum magnesium levels and women with preterm labour, and to compare these values with those patients who have a term delivery.Methods: The subjects included 100 pregnant women with preterm labour (cases) between 28 and 37 weeks gestation (Group A) and similar number of pregnant women with term labour (controls) between 37 and 40 weeks (Group B). Inclusion criteria for cases was singleton pregnancy, painful uterine contractions more than two in 30 minutes, intact fetal membranes, cervical dilatation (at least 1 cm) and effacement (80%). Serum magnesium levels were done in both the groups. Patients were followed until delivery. Routine antenatal investigations were done. Serum levels of magnesium were estimated by Erba’s semi auto-analyser.Results: 62% patients in Group A were from rural areas. More patients in Group A (70%) were from low socioeconomic class. More women in Group A were anaemic (44%). Mean value of hemoglobin in Group A was 9.93gm/dL. More patients in Group A had muscle cramps (89%). VLBW (<1500gm) neonates were more in Group A (21%). Also, LBW (1500-2499gm) neonates were more in Group A (60%). Mean neonatal birth weight in Group A (1907.3gm) was less. Neonatal morbidity and mortality was observed significantly more in Group A. Mean serum magnesium was less in Group A. Mean serum magnesium levels in primi and multigravida patients were less in Group A. Moreover, mean serum magnesium levels were less in urban and rural patients in Group A. Mean serum magnesium levels were less in normal and overweight patients in Group A. Also, mean serum magnesium levels were less in patients with cervical dilatation <3cm and >3cm in Group A.Conclusions: Low maternal serum magnesium level is associated with preterm labour. Patients with preterm labour have significantly low serum magnesium level when compared with labour at term.

scholarly journals Correlation of Serum Magnesium Level and Blood Glucose status among Type 2 Diabetic Patients

2021 ◽  
Vol 8 (2) ◽  
pp. 106-109
Author(s):  
KAM Mahbub Hasan ◽  
Asraful Hoque ◽  
Naheed Fatema ◽  
Mohammed Rashed Anwar ◽  
AKM Mohiuddin Bhuiyan ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Diabetic Patients ◽  
Serum Magnesium Level ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

Background: Serum magnesium level is an important electrolytes for the maintenance of haemodynamic of the body. Objective: The purpose of the present study was to correlate the serum magnesium level and blood sugar status. Methodology: This cross sectional study was carried out in the Department of Medicine at Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh from July 2012 to December 2012. All the type 2 diabetic patients admitted in the Department of Medicine in-patient department of ShSMCH who were 18 years and above age with both sexes were included as study population and were designated as group A and non-diabetic patients were included as group B. Blood samples were drawn after an overnight fast for the measurement of fasting blood sugar and serum magnesium. Result: In this present study a total number of 60 patients were enrolled for this study after fulfilling the inclusion and exclusion criteria of which 30 patients were in group A and the rest 30 patients were in group B. The correlation coefficient of FBS and HbA1C with Serum Magnesium level was recorded. The FBS and serum magnesium was negatively correlated to each other significantly which was -0.534. The HbA1C and serum magnesium was negatively correlated to each other significantly which was -0.556. Conclusion: In conclusion the blood sugar level is inversely correlate with the serum magnesium level in type 2 diabetic patients. Journal of Current and Advance Medical Research, July 2021;8(2):106-109

scholarly journals Association between Serum Magnesium and Erythropoietin Responsiveness in Hemodialysis Patients: A Cross-Sectional Study

2019 ◽  
Vol 44 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Ling Yu ◽  
Jinghong Song ◽  
Xiangxue Lu ◽  
Yuan Zu ◽  
Han Li ◽  
...  
Keyword(s):  
Protective Factor ◽  
Serum Magnesium ◽  
Laboratory Data ◽  
Resistance Index ◽  
Magnesium Level ◽  
Multivariate Logistic Regression Model ◽  
Maintenance Hemodialysis ◽  
Serum Magnesium Level ◽  
Group A ◽  
Group B

Background/Aims: As shown in the China Health and Nutrition Survey, serum magnesium is associated with anemia. However, the roles of magnesium in anemia and erythropoietin (EPO) responsiveness remain unclear in maintenance hemodialysis (MHD) patients. This study aims to investigate the level of serum magnesium and its relationship with EPO responsiveness in MHD patients. Methods: A total of 307 MHD patients were recruited for this survey. Laboratory data and anthropometrics were collected. EPO responsiveness was evaluated by the erythropoietin resistance index (ERI). The subjects were divided into 3 groups according to serum magnesium concentrations (group A, the lowest tertile; group B, the middle tertiles; and group C, the highest tertile). Multivariate logistic regressions were conducted to evaluate the factors that may be associated with EPO responsiveness. Results: The mean serum magnesium level was significantly higher than normal levels in MHD patients, while no hypomagnesemia was observed. A multivariate logistic regression model revealed that high-sensitivity C-reactive protein, intact parathyroid hormone, serum albumin, and magnesium levels were correlated with a high ERI. The OR of a high ERI was found to be 2.57 (95% CI 1.330–4.975, p = 0.005) for group A and 1.66 (95% CI 0.878––3.140, p > 0.05) for group B compared with the OR for group C. Conclusion: Serum magnesium levels were higher than normal levels in MHD patients. A high serum magnesium level was correlated with good EPO responsiveness and was therefore suggested to be a protective factor for EPO hyporesponsiveness.

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