Spatiotemporal Trends of Colorectal Cancer Mortality Due to Low Physical Activity and High Body Mass Index From 1990 to 2019: A Global, Regional and National Analysis

Background: Understanding the spatiotemporal trends of colorectal cancer (CRC) deaths caused by low physical activity (LPA) and high body mass index (BMI) is essential for the prevention and control of CRC. We assessed patterns of LPA and high BMI-induced CRC deaths from 1990 to 2019 at global, regional, and national levels.Methods: Data on CRC deaths due to LPA and high BMI was downloaded from the Global Burden of Disease 2019 Study. We calculated estimated annual percentage change (EAPC) to quantify spatiotemporal trends in the CRC age-standardized mortality rate (ASMR) due to LPA and high BMI.Results: In 2019, CRC deaths due to LPA and high BMI were estimated as 58.66 thousand and 85.88 thousand, and the corresponding ASMRs were 0.77/100,000 and 1.07/100,000, with EAPCs of−0.39 [95% confidence interval (CI):−0.49,−0.29] and 0.64[95% CI: 0.57, 0.71] from 1990 to 2019 respectively. Since 1990, the ASMR of CRC attributable to LPA and high BMI has been on the rise in many geographic regions, especially in low middle and middle sociodemographic index (SDI) regions. Thirteen countries had a significant downward trend in CRC ASMR attributed to LPA, with EAPCs < −1. And, only 4 countries had a significant downward trend in CRC ASMR attributable to high BMI, with EAPCs < −1. Countries with a higher baseline burden in 1990 and a higher SDI in 2019 had a faster decline in ASMR due to high BMI and LPA.Conclusions: The burden of CRC caused by LPA and high BMI is on the rise in many countries. Countries should adopt a series of measures to control the local prevalence of obesity and LPA in order to reduce disease burden, including CRC.

Evaluating a Social Media Campaign for a Parent Educational Video on Bronchiolitis

Bronchiolitis, or lower airway swelling, is a common cause of pediatric hospital admissions. Parents have expressed wishes for more information regarding bronchiolitis but had difficulty finding reliable information, suggesting the need for more effective and easily accessible information resources. Knowledge translation (KT) tools like videos provide research-based information and may be conveniently disseminated to large audiences through social media. The purpose of this project was to evaluate the effectiveness of a social media campaign to promote a video on bronchiolitis. A social media campaign was conducted from 14 October to 30 November 2019. User interactions were recorded for the Facebook and Twitter accounts, website, and YouTube of Evidence in Child Health to Enhance Outcomes (ECHO), Alberta Research Centre for Health Evidence (ARCHE), and Translating Emergency Knowledge for Kids (TREKK). Baseline metrics were collected from 1 August to 30 September 2019 and post-campaign metrics were collected from 1 December 2019 to 31 March 2020. Mean monthly changes, standard deviations, and percent changes between periods were generated for the baseline, campaign, and post-campaign periods. Overall, there was a visible increase in user interactions throughout the campaign period. There was an overall downward trend in user interactions following the campaign. These findings suggest that social media may be a useful method of KT tool dissemination when consistently used. The downward trend post-campaign highlights the need for further research to investigate methods to maintain continuous interaction following a campaign.

OCLC library holdings: assessing availability of academic books in libraries in print and electronic compared to citations and altmetrics

Although library holding data is constructed upon work format of books, it is less known how much print and electronic books in libraries contribute to the library holding counts. In response, this research is an attempt to explore the distribution of library holding data across work formats and investigate the availability of library print holdings and library electronic holdings for books as constituents of the library holding metric across fields and over time and compared with other book metrics. ISBNs, titles and author names of 119,794 Scopus-indexed book titles across 26 fields were examined for fourteen variables including OCLC Library Holdings, Scopus Citations, Google Books Citations, Goodreads engagements, and Altmetric indicators. There are three major findings: (a) library holdings are a more comprehensively available metric for books (over 97%) than any other metric and could be useful after short time after first edition publication, followed by Google Books, Goodreads and Scopus, respectively; (b) on average electronic holdings are seven times (median three times) more numerous than print holdings and their ratio is growing considerably for more recent books; (c) there is consistent downward trend in average print book holdings, suggesting that library print holding data are cumulative in nature and statistically comparable to formal citations; however, acquisition of electronic books in libraries is inconsistent in distribution plot as well as over time. In sum, the differences between print and electronic holding data are broad making them distinct metrics, suggesting that further research is needed for understanding their implications for book impact assessment.

Nitrogen Migration and Transformation Mechanism in the Groundwater Level Fluctuation Zone of Typical Medium

Because of the nitrogen pollution problem in groundwater, the migration conversion mechanism of nitrogen in groundwater level fluctuations was analyzed. Technology and methods through indoor experiments and theoretical analysis were used to study coarse sand, medium sand, and fine sand groundwater level fluctuation in the aeration zone and saturated zone under the situation of nitrogen distribution characteristics, revealing groundwater level fluctuation with the nitrogen migration mechanism. The experimental results showed that the variation range of the nitrate-nitrogen (NO3−−N) concentration with the water level is medium sand > fine sand > coarse sand. The ammonium nitrogen (NH4+−N) concentration showed a downward trend after water level fluctuations, and there were more apparent fluctuations in coarse sand and medium sand. The nitrite nitrogen (NO2−−N) in coarse sand and medium sand first increased the water level and then gradually reached a balance. The sampling points below the water level in fine sand showed a downward trend with fluctuation of the water level, and then gradually reached equilibrium. The results provide a scientific basis for the remediation and treatment of soil and groundwater pollution.

SOCIAL INSURANCE AND FEATURES TAXATION OF FARMS

There are farms (individual and family) an important component agricultural sector of Ukraine’s economy and effective 224 mechanism that promotes increasing employment and income growth in rural areas, involvement investment resources in agricultural production [1]. Domestic farmers, despite certain economic problems, provide more efficient use of agricultural resources, as it is fully implemented here economic interest the producers themselves, who are mainly owners of these resources, or on lease terms use some of them. In recent years, there has been a negative downward trend in Ukraine number of farms. The main reason for this situation is domestic agrarian experts call the lack of potential farmers start-up capital, on the basis which it would be possible to build an efficiently functioning agricultural production.

Gross Motor Coordination: We Have a Problem! A Study With the Körperkoordinations Test für Kinder in Youth (6–13 Years)

The main goal of our cross-sectional research was to determine the current values of gross motor coordination (GMC) of Italian boys and girls between 6 and 13 years of age. Secondary goals were to study gender differences, and the four subtests trend with ages. Results were compared with the references proposed by KTK authors and with similar searches. Anthropometric measurements and KTK data from 2,206 schoolchildren (girls: n = 1,050; boys: n = 1,156) were collected. The KTK raw score (RS) increased with the age of the subjects (r = 0.678; p < 0.001). In 11–13-year-old subjects, the increase in results is less than in younger subjects. RS showed differences by gender (F = 5.899; p = 0.015) and age (F = 269.193; p < 0.001) without interaction gender × age. Motor quotient (MQ) tended to decrease with age (r = −0.148; p < 0.001); it showed differences by gender (F = 79.228; p < 0.001), age (F = 14.217; p < 0.001), and an interaction gender × age (F = 2.249; p < 0.05). Boys showed better performance than did girls in the raw scores of three of four subtests (JS: F = 24.529; MS: F = 9.052; HH: F = 11.105). Girls show better performances than did boys in the WB (F = 14.52). Differences between genders make us believe it appropriate to maintain a differentiated standardization. RS increased with age, and it seems reasonable, therefore, to maintain a GMC age-based normalization. On the contrary, MQ tended to decrease. All this makes us speculate that today's young people accumulate less significant motor experiences over the years compared to those achieved by their peers in the 1970s. Italian data were lower than German references and Belgian results but slightly higher than the Brazilian ones. The comparison among these four searches confirmed a worrying downward trend in GMC and its characterization by geographical and sociocultural areas. Updated parameters of the KTK can provide helpful references to improve policies to support physical activity, sport, and physical education in youth.

Distribution and Quantification of 1,2-Propylene Glycol Enantiomers in Baijiu

Enantiomers of 1,2-Propylene glycol (1,2-PG) were investigated in 64 commercial Chinese Baijiu including soy sauce aroma-type Baijiu (SSB), strong aroma-type Baijiu (STB), and light aroma-type Baijiu (LTB), via chiral gas chromatography (β-cyclodextrin). The natural enantiomeric distribution and concentration of 1,2-PG in various baijiu were studied to evaluate whether the distribution and content of the two isomers of 1,2-PG were correlated with the aroma type and storage year. The results showed that 1,2-PG has a high enantiomeric ratio and the (S)-configuration predominated in SSB. The average S/R enantiomeric ratio of this compound in SSB was approximately 87:13 (±3.17), with an average concentration of 52.77 (±23.70) mg/L for the (S)-configuration and 8.72 (±3.63) mg/L for the (R)-enantiomer. The (R)-configuration was predominant in the STB, whereas neither (S) nor (R)-form of 1,2-PG were detected in LTB. The content of the two configurations of 1,2-PG in the JSHSJ vintage of SSB showed a wave variation, with an average S/R enantiomeric ratio of 89:11 (±1.15). The concentration of (R)-1,2-PG in XJCTJ vintage liquors showed an upward and then downward trend with aging time, with an overall downward trend, and the concentration of (S)-form showed a wavy change with an overall upward trend. Except for the LZLJ-2019 vintage where both (R) and (S)-1,2-PG were present, all other samples only existed (R)-form, and a decreasing trend of (R)-enantiomer with aging time was observed. The enantiomeric ratio of 1,2-PG might be one of the potential markers for adulteration control of Baijiu as industrial 1,2-PG usually presented in the racemic mixture. Sensory analysis revealed olfactory thresholds of 4.66 mg/L and 23.92 mg/L for the (R)- and (S)-configurations in pure water respectively. GC-O showed both enantiomers exhibited different aromatic nuances.

Histogenous Hypoxia and Acid Retention in Schizophrenia: Changes in Venous Blood Gas Analysis and SOD in Acute and Stable Schizophrenia Patients

Background: Oxidative stress may play an important role in the pathogenesis of schizophrenia (SCH), and there is considerable indirect evidence that hypoxia is closely related to SCH, but direct evidence of hypoxia in SCH has never been found.Methods:In this study, superoxide dismutase (SOD), venous blood gas, and Positive and Negative Syndrome Scale (PANSS) were examined in 40 SCH patients and compared with those of 40 healthy controls. The patients were treated with combination of atypical antipsychotics and Ditan Huayu Lishen decoction (a Chinese medicine decoction) and examined in the acute and stable period, respectively. Comparisons of indicators between two groups were performed using an independent-samples t-test, comparison of indicators between the acute and stable periods in the SCH group was performed using paired-samples t-test. Pearson correlation and multiple linear regression analyses were performed to investigate the relationships between the effect indicators.Results: Higher venous pH, PvO2, and fasting blood glucose levels and lower SOD, lactic acid, and PvCO2 levels were found in SCH patients compared with the control group; SOD was negatively correlated with the general psychopathology subscale score (PANSS-G), and PvO2 levels were closely related to venous pH in SCH and related to PvCO2 in the control group. It was also found that SOD activity showed no significant difference in acute and stable period, whereas PvO2 showed a downward trend, and venous pH was decreased significantly after treatment. Both the venous pH and PvO2 were higher in patients with SCH than that in healthy controls.Conclusion: It suggests that histogenous hypoxia and acid retention exist in relation to SCH, and there is an improvement of acid retention and a downward trend in histogenous hypoxia after combination treatment. Venous pH, PvO2, and PvCO2 are trait variables, but not state variables of SCH. The theory of histogenous hypoxia and acid retention can well explain the decrease in pH value and the increase in lactic acid in brain tissue of patients with SCH. Histogenous hypoxia and acid retention closely related to glucose metabolism. So they may play an important role in pathophysiology for SCH.

DDT in Crimea coastal waters and blubber of Black Sea cetaceans

This research is based on the multi-year data on the distribution of organochlorine pesticides of the DDT group in the water of the coastal Black Sea areas of Crimea, obtained in expeditions of the “Professor Vodyanitsky” research vessel from 1999 to 2020. Study of content of DDT and its metabolites (DDTs) in the blubber of three species of Black Sea cetaceans that were astrand on the Black Sea coast from the 1980s to the 2020s was grounded on own and literature data. While there was an overall significant variability in ∑DDT content during the study period, there was a significant downward trend in their concentrations in the water of coastal areas of Crimea. Despite the significantly decreased DDTs pollution of the habitat of the Black Sea marine mammals over the last 10 years, high concentrations of DDTs were accumulated in their blubber, the maximum value of the sum of DDTs concentrations reached (163 µg/g of lipids) in the blubber of adult depleted bottlenose dolphin. The minimum concentrations were determined in the blubber of a newborn harbour porpoise female. In blubber samples up to 70% was of DDE, DDD - from 21 to 24%, and the concentration of the initial DDT varied from 6 to 14%. Based on the analysis of own and literature data, it is assumed that in the modern period, as compared to the 1990s, there is a downward trend in the content of the DDTs in the blubber of Black Sea cetaceans.

Financial Condition and Bankruptcy Likelihood in Aviation on the Example of the Aeroflot Company

This study analyses theoretical aspects of bankruptcy and financial analysis. Analysis of bankrupt cy diagnostics is the most important condition for successful company management since the results of economic activity depend on the availability and efficiency of the use of financial resources. The study of the institution of bankruptcy is essential for high-quality business conduct. Thus, as a practical part this study implemented analyses of financial condition and bankruptcy likelihood in aviation on the example of one of the biggest airlines – PJSC Aeroflot. Research resulted in findings confirming the instability of the company’s financial condition and downward trend on the Z index related to decrease in demand, mostly due to the pandemic of COVID-19.