scholarly journals Cross-sectional study evaluating data quality of the National Cancer Registration and Analysis Service (NCRAS) prostate cancer registry data using the Cluster randomised trial of PSA testing for Prostate cancer (CAP)

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e015994 ◽  
Author(s):  
Samuel William David Merriel ◽  
Emma L Turner ◽  
Eleanor Walsh ◽  
Grace J Young ◽  
Chris Metcalfe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomised Trial ◽  
Tnm Stage ◽  
Cancer Registration ◽  
Cluster Randomised Trial ◽  
Gleason Grade ◽  
Cross Sectional ◽  
Cancer Data ◽  
Psa Testing ◽  
Cluster Randomised

ObjectivesTo compare the completeness and agreement of prostate cancer data recorded by the National Cancer Registration and Analysis Service (NCRAS) with research-level data specifically abstracted from medical records from the Cluster randomised triAl of prostate specific antigen (PSA) testing for Prostate cancer (CAP) trial.DesignCross-sectional comparison study.ParticipantsWe included 1356 men from the CAP trial cohort who were linked to the NCRAS registry.Primary and secondary outcome measuresCompleteness of prostate cancer data in NCRAS and CAP and agreement for tumour, node, metastases (TNM) stage (T1/T2; T3; T4/N1/M1) and Gleason grade (4–6; 7; 8–10), measured by differences in proportions and Cohen’s kappa statistic. Data were also stratified by year and pre-2010 versus post-2010, when NCRAS reporting standards changed.ResultsCompared with CAP, completeness was lower in NCRAS for Gleason grade (41.2% vs 76.7%, difference 35.5, 95% CI 32.1 to 39.0) and TNM stage (29.9% vs 67.6%, difference 37.6, 95% CI 34.1 to 41.1). NCRAS completeness for Gleason grade (pre-2010 vs post-2010 31.69% vs 64%; difference 32.31, 95% CI 26.76 to 37.87) and TNM stage (19.31% vs 55.50%; difference 36.19, 95% CI 30.72 to 41.67) improved over time. Agreement for Gleason grade was high (Cohen’s kappa, κ=0.90, 95% CI 0.88 to 0.93), but lower for TNM stage (κ=0.41, 95% CI 0.37 to 0.51) overall. There was a trend towards improved agreement on Gleason grade, but not TNM stage, when comparing pre-2010 and post-2010 data.ConclusionNCRAS case identification was very high; however, data on prostate cancer grade was less complete than CAP, and agreement for TNM stage was modest. Although the completeness of NCRAS data has improved since 2010, the higher completeness rate in CAP demonstrates that gains could potentially be achieved in routine registry data. This study’s findings highlight a need for improved recording of stage and grade data in the source medical records.

scholarly journals Design and preliminary recruitment results of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP)

2014 ◽  
Vol 110 (12) ◽  
pp. 2829-2836 ◽  
Author(s):  
E L Turner ◽  
◽  
C Metcalfe ◽  
J L Donovan ◽  
S Noble ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomised Trial ◽  
Cluster Randomised Trial ◽  
Psa Testing ◽  
Cluster Randomised

scholarly journals Effect of a mass radio campaign on family behaviours and child survival in Burkina Faso: a repeated cross-sectional, cluster-randomised trial

2018 ◽  
Vol 6 (3) ◽  
pp. e330-e341 ◽  
Author(s):  
Sophie Sarrassat ◽  
Nicolas Meda ◽  
Hermann Badolo ◽  
Moctar Ouedraogo ◽  
Henri Some ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Child Survival ◽  
Randomised Trial ◽  
Cluster Randomised Trial ◽  
Cross Sectional ◽  
Cluster Randomised ◽  
Radio Campaign

scholarly journals Decision aid and cost compensation influence uptake of PSA-based early detection without affecting decisional conflict: a cluster randomised trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dorothee Tiedje ◽  
Matthias Borowski ◽  
Alexandra Simbrich ◽  
Kathrin Schlößler ◽  
Klaus Kruse ◽  
...  
Keyword(s):  
Early Detection ◽  
Primary Endpoint ◽  
Decision Aid ◽  
Randomised Trial ◽  
Specific Antigen ◽  
Decisional Conflict ◽  
Cluster Randomised Trial ◽  
Psa Test ◽  
Psa Testing ◽  
Cluster Randomised

AbstractInternational guidelines recommend to inform men about the benefits and harms of prostate specific antigen (PSA) based early detection of prostate cancer. This study investigates the influence of a transactional decision aid (DA) or cost compensation (CC) for a PSA test on the decisional behaviour of men. Prospective, cluster-randomised trial to compare two interventions in a 2 × 2 factorial design: DA versus counselling as usual, and CC versus noCC for PSA-testing. 90 cluster-randomised physicians in the administrative district of Muenster, Germany recruited 962 participants aged 55–69 yrs. in 2018. Primary endpoint: the influence of the DA and CC on the decisional conflict. Secondary endpoints: factors which altered the involvement of the men regarding their decision to take a PSA-test. The primary endpoint was analysed by a multivariate regression model. The choice to take the PSA test was increased by CC and reduced by the DA, the latter also reduced PSA uptake in men who were offered CC. The DA led to an increase of the median knowledge about early detection, changed willingness to perform a PSA test without increasing the level of shared decision, giving participants a stronger feeling of having made the decision by themselves. The DA did not alter the decisional conflict, as it was very low in all study groups. DA reduced and CC increased the PSA uptake. The DA seemed to have a greater impact on the participants than CC, as it led to fewer PSA tests even if CC was granted.Trial registration: German Clinical Trial Register (Deutsches Register Klinischer Studien DRKS00007687). Registered: 06/05/2015. https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00007687.

scholarly journals Can lay health workers support the management of hypertension? Findings of a cluster randomised trial in South Africa

2018 ◽  
Vol 3 (1) ◽  
pp. e000577 ◽  
Author(s):  
Jane Goudge ◽  
Tobias Chirwa ◽  
Sandra Eldridge ◽  
Francesc Xavier F Gómez-Olivé ◽  
Chodziwadziwa Kabudula ◽  
...  
Keyword(s):  
Chronic Care ◽  
Health Workers ◽  
Clinical Care ◽  
Randomised Trial ◽  
Cluster Randomised Trial ◽  
Lay Health Workers ◽  
Cross Sectional ◽  
Middle Income ◽  
Cluster Randomised ◽  
Low Middle Income Countries

IntroductionIn low/middle-income countries with substantial HIV and tuberculosis epidemics, health services often neglect other highly prevalent chronic conditions, such as hypertension, which as a result are poorly managed. This paper reports on a study to assess the effect on hypertension management of lay health workers (LHW) working in South African rural primary healthcare clinics to support the provision of integrated chronic care.MethodsA pragmatic cluster randomised trial with a process evaluation in eight rural clinics assessed the effect of adding two LHWs supporting nurses in providing chronic disease care in each intervention clinic over 18 months. Control clinics continued with usual care. The main outcome measure was the change in the difference of percentage of clinic users who had elevated cardiovascular risk associated with high blood pressure (BP) before and after the intervention, as measured by two cross-sectional population surveys.ResultsThere was no improvement in BP control among users of intervention clinics as compared with control clinics. However, the LHWs improved clinic functioning, including overall attendance, and attendance on the correct day. All clinics faced numerous challenges, including rapidly increasing number of users of chronic care, unreliable BP machines and cuffs, intermittent drug shortages and insufficient space.ConclusionLHWs improved the process of providing care but improved BP control required improved clinical care by nurses which was compromised by large and increasing numbers of patients, the dominance of the vertically funded HIV programme and the poor standards of equipment in clinics.Trial registration numberISRCTN12128227.

Sign in / Sign up

Export Citation Format

Share Document