scholarly journals Effectiveness of pneumococcal and influenza vaccines to prevent serious health complications in adults with chronic liver disease: a protocol for a systematic review

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e018223 ◽  
Author(s):  
Suvi Härmälä ◽  
Constantinos Parisinos ◽  
Laura Shallcross ◽  
Alastair O’Brien ◽  
Andrew Hayward
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Influenza Vaccines ◽  
Primary Data ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Increased Risk ◽  
Study Results ◽  
Health Complications

IntroductionIn advanced chronic liver disease, diseases caused by common bacteriaStreptococcus pneumoniaeor influenza virus put people at an increased risk of serious health complications and death. The effectiveness of the available vaccines in reducing the risk of poor health outcomes, however, is less clear.Methods and analysisWe will search Medline (Ovid), Embase (Ovid), PubMed and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of pneumococcal and influenza vaccines in people with chronic liver disease. Two independent reviewers will screen the studies for eligibility, extract data and assess study quality and risk of bias. Random effects meta-analyses will be performed as appropriate.Ethics and disseminationFormal ethical approval is not required, as no primary data will be collected for this study. We will publish results of this study in relevant peer-reviewed medical journal or journals. Where possible, the study results will also be presented as posters or talks at relevant medical conferences and meetings.PROSPERO registration numberCRD42017067277.

Increased Risk of Chronic Liver Disease in Patients with Schizophrenia: A Population-Based Cohort Study

2014 ◽  
Vol 55 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Jer-Hwa Hsu ◽  
I-Chia Chien ◽  
Ching-Heng Lin ◽  
Yiing-Jenq Chou ◽  
Pesus Chou
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Population Based ◽  
Chronic Liver ◽  
Increased Risk

scholarly journals Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease

2009 ◽  
Vol 15 (20) ◽  
pp. 2506 ◽  
Author(s):  
Valter Donadon ◽  
Massimiliano Balbi ◽  
Michela Ghersetti ◽  
Silvia Grazioli ◽  
Antonio Perciaccante ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Antidiabetic Therapy ◽  
Increased Risk

Su1674 HANDGRIP STREGTH DICLINE IN CHRONIC LIVER DISEASE PATIENTS INDICTES INCREASED RISK OG FALLING.

2020 ◽  
Vol 158 (6) ◽  
pp. S-610
Author(s):  
Kei Ohnishi ◽  
Atsushi Hiraoka ◽  
Taisei Murakami ◽  
Eiji Tsubouchi ◽  
Tomoyuki Ninomiya ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Increased Risk

scholarly journals Effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in adults with cirrhosis: a protocol for a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e025664
Author(s):  
Suvi Härmälä ◽  
Constantinos Parisinos ◽  
Jennifer Ryan ◽  
Alastair O’Brien
Keyword(s):  
Renal Dysfunction ◽  
Evaluation System ◽  
Spontaneous Bacterial Peritonitis ◽  
Primary Data ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Bacterial Peritonitis ◽  
Study Results ◽  
Randomised Controlled ◽  
Albumin Therapy

IntroductionUse of albumin therapy is recommended for management of disease complications in cirrhosis. The effectiveness of albumin to prevent specific disease complications and death, however, is less clear.Methods and analysisWe will search Medline (Ovid), Embase (Ovid), Cochrane Hepato-Biliary Controlled Trials Register and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in cirrhotic patients. Two independent reviewers will screen the studies for eligibility, extract data and assess risk of bias and quality of evidence using Grading of Recommendations Assessment, Development and Evaluation system. Random effects meta-analyses will be performed when appropriate.Ethics and disseminationAs no primary data will be collected, a formal ethical approval is not required. We plan to publish the results of this study in a relevant peer-reviewed journal or journals. The study results may also be presented at relevant conferences and meetings.PROSPERO registration numberCRD42018100798.

scholarly journals Prediction of Esophageal Varices by Liver Stiffness and Platelets in Persons With Human Immunodeficiency Virus Infection and Compensated Advanced Chronic Liver Disease

2019 ◽  
Vol 71 (11) ◽  
pp. 2810-2817 ◽  
Author(s):  
Nicolás Merchante ◽  
Chiara Saroli Palumbo ◽  
Giovanni Mazzola ◽  
Juan A Pineda ◽  
Francisco Téllez ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Esophageal Varices ◽  
Liver Stiffness ◽  
Chronic Liver ◽  
Screening Criteria ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Validation Set

Abstract Background People living with human immunodeficiency virus (PLWH) are at increased risk of cirrhosis and esophageal varices. Baveno VI criteria, based on liver stiffness measurement (LSM) and platelet count, have been proposed to avoid unnecessary esophagogastroduodenoscopy (EGD) screening for esophageal varices needing treatment (EVNT). This approach has not been validated in PLWH. Methods PLWH from 8 prospective cohorts were included if they fulfilled the following criteria: (1) compensated advanced chronic liver disease (LSM >10 kPa); (2) availability of EGD within 6 months of reliable LSM. Baveno VI (LSM <20 kPa and platelets >150 000/μL), expanded Baveno VI (LSM <25 kPa and platelets >110 000/μL), and Estudio de las Hepatitis Víricas (HEPAVIR) criteria (LSM <21 kPa) were applied to identify patients not requiring EGD screening. Criteria optimization was based on the percentage of EGDs spared, while keeping the risk of missing EVNT <5%. Results Five hundred seven PLWH were divided into a training (n = 318) and a validation set (n = 189). EVNT were found in 7.5%. In the training set, Baveno VI, expanded Baveno VI, and HEPAVIR criteria spared 10.1%, 25.5%, and 28% of EGDs, while missing 0%, 1.2%, and 2.2% of EVNT, respectively. The best thresholds to rule out EVNT were platelets >110 000/μL and LSM <30 kPa (HIV cirrhosis criteria), with 34.6% of EGDs spared and 0% EVNT missed. In the validation set, HEPAVIR and HIV cirrhosis criteria spared 54% and 48.7% of EGDs, while missing 4.9% and 2.2% EVNT, respectively. Conclusions Baveno VI criteria can be extended to HEPAVIR and HIV cirrhosis criteria while sparing a significant number of EGDs, thus improving resource utilization for PLWH with compensated advanced chronic liver disease.

scholarly journals Patients With Diabetes and Chronic Liver Disease Are at Increased Risk for Overall Mortality: A Population Study From the United States

2017 ◽  
Vol 35 (2) ◽  
pp. 79-83 ◽  
Author(s):  
Maria Stepanova ◽  
Stephen Clement ◽  
Robert Wong ◽  
Sammy Saab ◽  
Aijaz Ahmed ◽  
...  
Keyword(s):  
United States ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Population Study ◽  
The United States ◽  
Chronic Liver ◽  
Increased Risk ◽  
Patients With Diabetes ◽  
Overall Mortality

Mo1017 Mothers With Chronic Liver Disease Have an Increased Risk for Preterm and Small-for-Gestational-Age Birth

2014 ◽  
Vol 146 (5) ◽  
pp. S-987 ◽  
Author(s):  
Knut Stokkeland ◽  
Fereshte Ebrahim ◽  
Jonas Ludvigsson ◽  
Rolf Hultcrantz ◽  
Anders Ekbom ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Chronic Liver ◽  
Increased Risk

scholarly journals Article Commentary: Insulin Resistance, Type 2 Diabetes and Chronic Liver Disease. A Deadly Trio

2009 ◽  
Vol 2 ◽  
pp. CMED.S3518 ◽  
Author(s):  
Amedeo Lonardo ◽  
Paola Loria
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Molecular Mechanisms ◽  
Viral Infections ◽  
Clinical Medicine ◽  
Morphological Characteristics ◽  
Chronic Liver ◽  
Increased Risk ◽  
History Of

In this commentary to the paper by Donadon V. et al (Clinical Medicine: Endocrinology and Diabetes. 2009;2:25–33.) the association and significance of insulin resistance with chronic liver disease are shortly reviewed and the molecular mechanisms underlying the diabetogenic and oncogenic potentials of advanced liver disease are summarized. Literature studies demonstrate that hepatocellular carcinoma (HCC) can be part of the natural history of NASH. HCCs in patients with features of metabolic syndrome as the only risk factor for liver disease have distinct morphological characteristics and mainly occur in the absence of significant fibrosis in the background liver. Moreover, data indicate that the presence of diabetes carries an approximately three to four-fold increased risk of HCC and such a risk is strongly increased by concurrent viral infections. Finally, the relationship between insulin resistance, steatosis and diabetes in NAFLD and HCV infection will be commented, along with the directions for future studies.

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