scholarly journals Detection of pulmonary nodules: a clinical study protocol to compare ultra-low dose chest CT and standard low-dose CT using ASIR-V

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e025661 ◽  
Author(s):  
Marie Ludwig ◽  
Emilie Chipon ◽  
Julien Cohen ◽  
Emilie Reymond ◽  
Maud Medici ◽  
...  
Keyword(s):  
Low Dose ◽  
Lung Nodule ◽  
Study Participant ◽  
Lung Cancer Screening ◽  
Chest Ct ◽  
Reference Level ◽  
Patient Identification ◽  
Blind Test ◽  
Informed Consent Form ◽  
Number Of Patients

IntroductionLung cancer screening in individuals at risk has been recommended by various scientific institutions. One of the main concerns for CT screening is repeated radiation exposure, with the risk of inducing malignancies in healthy individuals. Therefore, lowering the radiation dose is one of the main objectives for radiologists. The aim of this study is to demonstrate that an ultra-low dose (ULD) chest CT protocol, using recently introduced hybrid iterative reconstruction (ASiR-V, GE medical Healthcare, Milwaukee, Wisconsin, USA), is as performant as a standard ‘low dose’ (LD) CT to detect non-calcified lung nodules ≥4 mm.Methods and analysisThe total number of patients to include is 150. Those are referred for non-enhanced chest CT for detection or follow-up of lung nodule and will undergo an additional unenhanced ULD CT acquisition, the dose of which is on average 10 times lower than the conventional LD acquisition. Total dose of the entire exam (LD+ULD) is lower than the French diagnostic reference level for a chest CT (6.65 millisievert). ULD CT images will be reconstructed with 50% and 100% ASiR-V and LD CT with 50%. The three sets of images will be read in random order by two pair of radiologists, in a blind test, where patient identification and study outcomes are concealed. Detection rate (sensitivity) is the primary outcome. Secondary outcomes will include concordance of nodule characteristics; interobserver reproducibility; influence of subjects’ characteristics, nodule location and nodule size; and concordance of emphysema, coronary calcifications evaluated by visual scoring and bronchial alterations between LD and ULD CT. In case of discordance, a third radiologist will arbitrate.Ethics and disseminationThe study was approved by the relevant ethical committee. Each study participant will sign an informed consent form.Trial registration numberNCT03305978; Pre-results.

scholarly journals P2.11-16 Variability in Reading Low-Dose Chest CT: Individual Readers vs. Central Review in a Nationwide Lung Cancer Screening Project

2019 ◽  
Vol 14 (10) ◽  
pp. S798-S799
Author(s):  
E.J. Hwang ◽  
J.M. Goo ◽  
S.H. Yoon ◽  
H.Y. Kim ◽  
Y. Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Chest Ct

Wavelet Compression of Low-Dose Chest CT Data: Effect on Lung Nodule Detection

Radiology ◽  
2003 ◽  
Vol 228 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Jane P. Ko ◽  
Henry Rusinek ◽  
David P. Naidich ◽  
Georgeann McGuinness ◽  
Ami N. Rubinowitz ◽  
...  
Keyword(s):  
Low Dose ◽  
Lung Nodule ◽  
Chest Ct ◽  
Wavelet Compression ◽  
Lung Nodule Detection ◽  
Nodule Detection ◽  
Ct Data

scholarly journals Development and outcomes of a comprehensive multidisciplinary incidental lung nodule and lung cancer screening program

2020 ◽  
Author(s):  
Gregory LeMense ◽  
Ernest A. Waller ◽  
Cheryl Campbell ◽  
Tyler Bowen
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Screening Program ◽  
Lung Nodule ◽  
Lung Cancer Screening ◽  
Treatment Modalities ◽  
Lung Nodules ◽  
Hospital System ◽  
Number Of Patients

Abstract Background: Appropriate management of lung nodules detected incidentally or through lung cancer screening can increase the rate of early-stage diagnoses and potentially improve treatment outcomes. However, the implementation and management of comprehensive lung nodule programs is challenging. Methods: This single-center, retrospective report describes the development and outcomes of a comprehensive lung nodule program at a community practice in Tennessee. Computed tomography (CT) scans potentially revealing incidental lung nodules were identified by a computerized search. Incidental or screening-identified lung nodules that were enlarging or not seen in prior scans were entered into a nodule database and guideline-based review determined whether to conduct a diagnostic intervention or radiologic follow-up. Referral rates, diagnosis methods, stage distribution, treatment modalities, and days to treatment are reported. Results: The number of patients with lung nodules referred to the program increased over 2 years, from 665 patients in Year 1 to 745 patients in Year 2. Most nodules were incidental (62%-65%). Nodules identified with symptoms (15.2% in Year 1) or through screening (12.6% in Year 1) were less common. In Year 1, 27% (182/665) of nodules required a diagnostic intervention and 18% (121/665) were malignant. Most diagnostic interventions were image-guided bronchoscopy (88%) or percutaneous biopsy (9%). The proportion of Stage I-II cancer diagnoses increased from 23% prior to program implementation to 36% in Year 1 and 38% in Year 2. In screening cases, 71% of patients completed follow-up scans within 18 months. Only 2% of Year 1 patients under watchful waiting required a diagnostic intervention, of which 1% received a cancer diagnosis. Conclusions: The current study reports outcomes over the first two years of a lung cancer screening and incidental nodule program. The results show that the program was successful, given the appropriate level of data management and oversight. Comprehensive lung nodule programs have the potential to benefit the patient, physician, and hospital system.

Lung cancer screening in high-risk individuals with annual low-dose chest CT in a community setting.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e12529-e12529
Author(s):  
Niraj K. Gupta ◽  
Richard K Freeman ◽  
Susan Storey ◽  
Dave Reeves ◽  
Anthony Ascioti ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Low Dose ◽  
Community Setting ◽  
Lung Cancer Screening ◽  
Chest Ct
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