scholarly journals Effectiveness of interventions for dementia in low- and middle-income countries: protocol for a systematic review, pairwise and network meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e027851
Author(s):  
Maximilian Salcher-Konrad ◽  
Huseyin Naci ◽  
David McDaid ◽  
Suvarna Alladi ◽  
Deborah Oliveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Secondary Analysis ◽  
Routine Care ◽  
Middle Income ◽  
Middle Income Countries ◽  
Cochrane Database ◽  
Registration Number ◽  
Meta Analyses ◽  
Low And Middle Income

IntroductionThere are more people living with dementia in low- and middle-income countries (LMICs) than in high-income countries. Evidence-based interventions to improve the lives of people living with dementia and their carers are needed, but a systematic mapping of methodologically robust studies in LMICs and synthesis of the effectiveness of dementia interventions in these settings is missing.Methods and analysisA systematic review and meta-analysis will be conducted to answer the question: Which dementia interventions were shown to be effective in LMICs and how do they compare to each other? Electronic database searches (MEDLINE, EMBASE, PsycINFO, CINAHL Plus, Global Health, WHO Global Index Medicus, Virtual Health Library, Cochrane CENTRAL, Social Care Online, BASE, MODEM Toolkit, Cochrane Database of Systematic Reviews) will be complemented by hand searching of reference lists and local knowledge of existing studies from an international network of researchers in dementia from LMICs. Studies will be eligible for inclusion if they were published between 2008 and 2018, conducted in LMICs and evaluated the effectiveness of a dementia intervention using a study design that supports causal inference of the treatment effect. We will include both randomised and non-randomised studies due to an anticipated low number of well-conducted randomised trials in LMICs and potentially greater external validity of non-randomised studies conducted in routine care settings. In addition to narrative synthesis of the interventions, feasibility of pairwise and network meta-analyses will be explored to obtain pooled effects of relative treatment effects.Ethics and disseminationSecondary analysis of published studies, therefore no ethics approval required. Planned dissemination channels include a peer-reviewed publication as well as a website, DVD and evidence summaries.Prospero registration numberCRD42018106206.

scholarly journals Elasticity of alcohol consumption, alcohol-related harms, and drinking initiation in low- and middle-income countries: A systematic review and meta-analysis

2013 ◽  
Vol 2 (1) ◽  
pp. 45-58 ◽  
Author(s):  
Bundit Sornpaisarn ◽  
Kevin Shield ◽  
Joanna Cohen ◽  
Robert Schwartz ◽  
Jürgen Rehm
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Publication Bias ◽  
Meta Analysis ◽  
World Health ◽  
Middle Income ◽  
Middle Income Countries ◽  
Meta Analyses ◽  
Alcohol Price ◽  
Low And Middle Income

Sornpaisarn, B., Shield, K. Cohen, J., Schwartz, R. & Rehm, J. (2013). Elasticity of alcohol consumption, alcohol-related harms, and drinking initiation in low- and middle-income countries: A systematic review and meta-analysis. International Journal of Alcohol and Drug Research, 2(1), 45-58.  doi: 10.7895/ijadr.v2i1.50 (http://dx.doi.org/10.7895/ijadr.v2i1.50)Aim: To systematically review research outlining the effects of price and taxation on alcohol consumption, alcohol-related harms, and drinking initiation in low- and middle-income countries (LMIC).Design: The systematic review and meta-analyses were conducted according to internationally standardized protocols (Preferred Reporting Items for Systematic Review and Meta-Analysis; PRISMA). Data were collected up to June 2011 by searching the peer-reviewed article databases MEDLINE, EMBASE, PsycINFO, and EconLit, along with the World Health Organization’s gray literature Database of Abstracts of Reviews of Effects, and by reference tracking. The meta-analyses were performed using random effects analysis, tests for publication bias, and sensitivity analyses.Measures: Any type of association between alcohol price and/or taxation and alcohol consumption, alcohol-related harms, and alcohol drinking initiation in LMIC.Findings: Our systematic search disclosed 12 studies that outlined an association between alcohol price or taxation and alcohol consumption in LMIC, while no articles were found that outlined a relationship between taxation and/or price and alcohol-related harms or drinking initiation in LMIC. The elasticity estimates were –0.64 (95% CI: –0.80 to –0.48) for total consumption of alcohol, –0.50 (95% CI: –0.78 to –0.21) for consumption of beer, and –0.79 (95% CI: –1.09 to –0.49) for consumption of other alcoholic beverages. Publication bias did not significantly affect the estimated elasticities.Conclusion: Price elasticity of demand for alcohol in LMIC is similar to that found in high-income countries. There is an imperative need for research on the association between alcohol price or taxation and alcohol-related harms and drinking initiation in LMIC.

scholarly journals Seroprevalence of SARS CoV-2 infection in Low and Middle-Income Countries and risk classification in the context of rolling out vaccine candidate across these countries : Protocol for a systematic review and meta-analysis

2021 ◽  
Author(s):  
Martin Ackah ◽  
Louise Ameyaw ◽  
Kwadwo Owusu Akuffo ◽  
Cynthia Osei Yeboah ◽  
Nana Esi Wood ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Vaccine Candidate ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Research Database ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Low And Middle Income

Abstract Background Seroprevalence of SARS Cov-2 provides a good indication of the extent of exposure and spread in the population, as well as those likely to benefit from a vaccine candidate. To date, there is no published or ongoing systematic review on the seroprevalence of COVID-19 in Low- and Middle-Income Countries (LMICs). This systematic review and meta-analysis will estimate SARS Cov-2 seroprevalence and the risk factors for SARS Cov-2 infection in LMICs.Methods We will search PubMed, EMBASE, WHO COVID-19 Global research database, Google Scholar, the African Journals Online, LILAC, HINARI, medRxiv, bioRxiv and Cochrane Library for potentially useful studies on seroprevalence of COVID-19 in LMICs from December 2019 to December 2020 without language restriction. Two authors will independently screen all the articles, select studies based on pre-specified eligibility criteria and extract data using a pre-tested data extraction form. Any disagreements will be resolved through discussion between the authors. The pooled seroprevalence of SARS CoV-2 for people from LMICs will be calculated. Random effects model will be used in case of substantial heterogeneity in the included studies, otherwise fixed-effect model will be used. A planned subgroup, sensitivity and meta-regression analyses will be performed. For comparative studies, the analyses will be performed using Review Manager v 5.4; otherwise, STATA 16 will be used. All effect estimates will be presented with their confidence intervals.Discussion The study will explore and systematically review empirical evidence on SARS Cov-2 seroprevalence in LMICs, and to assess the risk factors for SARS Cov-2 infection in Low Middle Income Countries in the context of rolling out vaccines in these countries. Finally, explore risk classifications to help with the rolling out of vaccines in LMICs.Systematic review registration: The protocol for this review has been registered in PROSPERO (CRD422020221548).

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