scholarly journals Dose–response relationship between urinary PAH metabolites and blood viscosity among coke oven workers: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e046682
Author(s):  
Min Wu ◽  
Chengjuan Liu ◽  
Huimin Wang ◽  
Jisheng Nie ◽  
Jin Yang
Keyword(s):  
Cardiovascular Disease ◽  
Dose Response ◽  
Coke Plant ◽  
Coke Oven ◽  
Cross Sectional Study ◽  
Plasma Viscosity ◽  
Secondary Outcome ◽  
Cross Sectional ◽  
Polycyclic Aromatic ◽  
Coke Oven Workers

ObjectivesPolycyclic aromatic hydrocarbons (PAHs) have been proven to be a risk factor for cardiovascular disease in coke oven workers, and increased plasma viscosity is a signal for higher risk of catching up cardiovascular disease. We want to explore whether the plasma viscosity is affected by the concentration of PAHs.DesignOur study is a cross-sectional dose–response study.SettingParticipants in this study came from a coke plant in Taiyuan, Shanxi.ParticipantsWe used data of 693 coke oven workers in Taiyuan.Primary and secondary outcome measuresWe assumed that plasma viscosity would increase as the concentration of PAHs metabolites in urine increases. We found that 2-hydroxyfluorene (OHFLU2) and plasma viscosity have a stable linear relationship in different statistical methods.ResultsWe found that plasma viscosity increased by 1.14 (mPa.s,30/s) for each ng/mL of 2-OHFLU urinary (correlation coefficient range: 0.54–1.74, p<0.05).ConclusionsThe results of this study could provide evidence for coke oven workers to prevent cardiovascular disease by checking whether plasma viscosity is elevated.

scholarly journals Validating a previously untested Intentions and Beliefs around Smoking sub-scale for inclusion in the published Attitudes and Beliefs about Cardiovascular Disease (ABCD) Risk Questionnaire using a cross-sectional sample

2021 ◽  
Author(s):  
Mark Bowyer ◽  
Hamid Yimam Hassen
Keyword(s):  
Public Health ◽  
Cardiovascular Disease ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Attitudes And Beliefs ◽  
Cross Sectional ◽  
Survey Tool ◽  
Horizon 2020 ◽  
Public Health Practitioners ◽  
Smoking Behaviours

Objectives: To provide evidence of validity, reliability and generalisability of results obtained using the Attitudes and Beliefs about Cardiovascular Disease (ABCD) Risk Questionnaire with a sample of the English population surveyed within the SPICES Horizon 2020 project (Nottingham study site), and to specifically evaluate the psychometric and factor properties of an as-yet untested 5 item sub-scale relating to smoking behaviours. Design and setting: Community based cross-sectional study in Nottingham, UK. Participants: 466 English adults fitting inclusion criteria (aged 18+, without known history of CVD, not pregnant, able to provide informed consent) were included in the study. Methods: We re-validated the published ABCD questionnaire on a sample of the general population in Nottingham to confirm the psychometric properties. Furthermore, we introduced 5 items related to smoking which were dropped in the original study due to inadequate valid samples. Primary and secondary outcome measures: Psychometric and factor performance of untested 5 item smoking behaviours sub-scale Psychometric and factorial properties in combination with the remaining 18 items across 3 sub-scales Results: Analyses of the data largely confirmed the validity, reliability, and factor structure of the original ABCD Risk Questionnaire. Sufficient participants in our study provided data against an additional five smoking related items to confirm their validity as a sub-scale and to advocate for their inclusion in future applications of the scale. EFA and CFA calculations support some minor changes to the remaining sub-scales which may further improve psychometric performance and therefore generalisability of the instrument. Conclusions: An amended version of the ABCD Risk Questionnaire would provide public health researchers and practitioners with a brief, easy to use, reliable and valid survey tool. The amended tool may now assist public health practitioners and researchers to quickly survey patient or public intentions and beliefs around three key areas of individually modifiable risk (Physical Activity, Diet, and Smoking).

scholarly journals Prevalence and coprevalence of chronic comorbid conditions in patients with type 2 diabetes in Catalonia: a population-based cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e031281 ◽  
Author(s):  
Manel Mata-Cases ◽  
Josep Franch-Nadal ◽  
Jordi Real ◽  
Marta Cedenilla ◽  
Didac Mauricio
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Primary Care ◽  
Chronic Conditions ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Sectional Study ◽  
Cross Sectional

ObjectivesTo evaluate the prevalence and coprevalence of several chronic conditions in patients with type 2 diabetes in a Mediterranean region.DesignA cross-sectional study.SettingTwo hundred and eighty-six primary care teams of the Catalonian Health Institute (Catalonia, Spain).ParticipantsWe included patients aged ≥18 years with a diagnosis of type 2 diabetes by 31 December, 2016, who were registered in the Information System for the Development of Research in primary care (SIDIAP) database. We excluded patients with a diagnosis of type 1 diabetes, gestational diabetes mellitus and any other type of diabetes.Primary and secondary outcome measuresWe collected data on diabetes-related comorbidities (ie, chronic complications, associated cardiovascular risk factors and treatment complications). Diagnoses were based on the International Classification of Diseases, 10thRevision codes recorded in the database or, for some entities, on the cut-off points for a particular test result or a specific treatment indicated for that entity. The presence and stage of chronic kidney disease (CKD) were based on the glomerular filtration rate, the CKD Epidemiology Collaboration creatinine equation and the urine albumin-to-creatinine ratio.ResultsA total of 373 185 patients were analysed. 82% of patients exhibited ≥2 comorbidities and 31% exhibited ≥4 comorbidities. The most frequent comorbidities were hypertension (72%), hyperlipidaemia (60%), obesity (45%), CKD (33%), chronic renal failure (CRF)(28%) and cardiovascular disease (23%). The most frequently coprevalent pairs of chronic conditions were the combination of hypertension with hyperlipidaemia (45%), obesity (35%), CKD (28%), CRF (25%) or cardiovascular disease (19%), as well as the combination of hyperlipidaemia with obesity (28%), CKD (21%), CRF (18%) or cardiovascular disease (15%); other common pairs of comorbidities were obesity/CKD, obesity/CRF, hypertension/retinopathy, hypertension/albuminuria, hypertension/urinary tract infection, CVD/CRF and CVD/CKD, which were each present in more than 10% of patients.ConclusionPatients with type 2 diabetes have a high frequency of coprevalence of metabolic risk factors, cardiovascular disease and CKD and thus require an integrated management approach.

scholarly journals Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons.

2013 ◽  
Vol 60 (3) ◽  
Author(s):  
Shanmugam Sureshkumar ◽  
Vellingiri Balachandar ◽  
Subramaniam Mohana Devi ◽  
Meyyazhagan Arun ◽  
Alagamuthu Karthickkumar ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Coke Plant ◽  
Coke Oven ◽  
Peripheral Blood Lymphocytes ◽  
Working Environment ◽  
Group I ◽  
Pcr Rflp ◽  
Polycyclic Aromatic ◽  
Coke Oven Workers

Polycyclic aromatic hydrocarbons (PAHs) result from the incomplete combustion of natural or synthetic organic materials. The working environment at a coke plant can negatively affect the employed workers who were exposed to coke oven emissions containing PAHs, which formed and released into the environment by the process of pyrolysis of coke. This study aims to analyze the relationship between the exposure of PAHs and the risk of genetic damages such as chromosomal alteration (CA), micronucleus (MN), and DNA damage (PCR-RFLP) in peripheral blood lymphocytes of 27 coke oven workers and equal number of control subjects. The exposed subjects and controls were divided into two groups based on their age (group I

scholarly journals Dose–response relationships between polycyclic aromatic hydrocarbon exposure and blood cell counts among coke oven workers: a sex-stratified analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e046843
Author(s):  
Chengjuan Liu ◽  
Min Wu ◽  
Mengmeng Fu ◽  
Huimin Wang ◽  
Jisheng Nie
Keyword(s):  
Dose Response ◽  
Coke Oven ◽  
Pah Metabolites ◽  
Female Workers ◽  
Cell Counts ◽  
Unit Increase ◽  
Polycyclic Aromatic ◽  
Complete Blood Counts ◽  
Coke Oven Workers ◽  
Male Workers

ObjectivesTo explore sex differences and dose–response relationships between nine urinary polycyclic aromatic hydrocarbon (PAH) metabolites and neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR) and complete blood counts among coke oven workers.Design and settingA cross-sectional study with stratified sex was conducted in Shanxi, China.ParticipantsA total of 458 male workers and 226 female workers were selected.Primary and secondary outcome measuresGeneral linear models, p values for trend tests and natural cubic spline models were used to explore the dose–response relationships between nine urinary PAH metabolites and NLR, PLR and complete blood counts.ResultCompared with male workers, female workers had lower exposure level of PAH (0.95 ng/mL vs 1.38 ng/mL). Only among female workers did we observe that a 1-unit increase in lg(1-OHPyr) was related to a 0.149 (95% CI: 0.055 to 0.242; p for trend=0.041) and 0.103 (95% CI: 0.025 to 0.181; p for trend=0.007) increase in lg(NLR) and lg(PLR), and a 0.116 (95% CI: −0.179 to –0.054; p for trend=0.007) decrease in lg(lymphocyte counts (LYMs)). A 1-unit increase in lg(2-OHNap) was related to a 0.045 (95% CI: 0.003 to 0.086; p for trend=0.037) increase in lg(PLR) and a 0.029 (95% CI: −0.056 to –0.002; p for trend=0.030) and 0.016 (95% CI: −0.029 to –0.003; p for trend=0.010) decrease in lg(white blood cell counts (WBCs)) and lg(haemoglobin (HGB)).ConclusionFemale workers’ NLR, PLR, WBCs, HGB and LYMs may be more susceptible than those of male workers when affected by PAH.

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