Chemotherapy in hodgkin’s disease (lymphadenoma)

1973 ◽  
Vol 11 (15) ◽  
pp. 57-59
Keyword(s):  
Lymph Nodes ◽  
Young Women ◽  
Hodgkin's Disease ◽  
Important Determinant ◽  
Hodgkin’S Disease ◽  
X Rays ◽  
Single Factor ◽  
Node Biopsy ◽  
Choice Of Treatment ◽  
Choice Of Therapy

The extent of Hodgkin’s disease at the time of diagnosis is the most important single factor affecting prognosis and the choice of treatment.1 2 Thorough investigation is needed to determine the stage of the disease,3 and it is best to refer patients to a centre with special experience of the condition. The staging process requires haematological, biochemical and radiographic studies, including abdominal lymphography.4 Some patients may also need laparotomy with splenectomy and hepatic and node biopsy to localise any intra-abdominal spread, particularly into the liver which is ominous and an important determinant in the choice of therapy.5 6 Laparotomy is less usually performed in patients over 60. In children under 6 splenectomy should not be carried out because it makes them more susceptible to infection.7 In young women the ovaries may be sewn to the abdominal wall in the mid-line so that they can be shielded from x-rays directed at iliac lymph nodes.

Tissue T-lymphocytes in untreated Hodgkin's disease morphologic and functional correlations in spleens and lymph nodes

Cancer ◽  
1982 ◽  
Vol 50 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Carlo D. Baroni ◽  
Luigi Ruco ◽  
Stefania Uccini ◽  
Antonio Foschi ◽  
Massimo Occhionero ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lymph Nodes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease

scholarly journals Atypical hodgkin and reed-sternberg cells in peripheral blood of a patient with advanced stage of Hodgkin's disease - a case report

2003 ◽  
Vol 131 (9-10) ◽  
pp. 400-402 ◽  
Author(s):  
Rajko Milosevic ◽  
Milica Colovic ◽  
Vesna Cemerikic-Martinovic ◽  
Natasa Colovic ◽  
Marina Bogunovic
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Mononuclear Cells ◽  
Hodgkin’S Disease ◽  
Lymphoid Cells ◽  
High Dose ◽  
Advanced Stage ◽  
Neck Lymph Nodes

The occurrence of abnormal Hodgkin's and Reed-Sternberg cells in the peripheral blood in a patient suffering from Hodgkin's disease has been noticed exceptionally rare in a previous period, and especially rare in last ten years primarily due to successfull treatment of this disease. The presence of atypical mononuclear cells in peripheral blood which cytomorphologically resembled Reed-Sternberg cells was registered in 8 patients till 1966. During the last decade, the presence of atypical mononuclear cells in the peripheral blood was used for their isolation cultivation, and detailed immunophenotypic and genetic analysis. The analysis of mononuclear cells in rare patients with Hodgkin's disease was established that they belong to the B-lymphoid cells with expression of CD30 and CD15 antigens. The examination of presence of Hodgkin's cells in the peripheral blood of patients with Hodgkin's disease is important for patients with advanced stage of the disease in which autologous stem cell transplantation and high dose chmeotherapy is planned. The authors present a 33-year-old patient, who noticed enlarged neck lymph nodes in September 2000, high temperature and loss in weight. On physical examination enlarged neck lymph nodes 5x8 cm and hepatosplenomegaly were found. There was anemia and thrombo-cytopenia, and normal WBC count with 24% of lymphoid elements in differential formula. On histologic examination of lymph nodes Hodgkin?s disease, type nodular sclerosis with mixed cellularity was found. Histology of bone marrow showed nodal lymphomatous infiltration. Immunohistochemistry with monoclonal antibodies of concentrate of peripheral blood cells showed expression of CD30+ and CD15+, immunophenotypically and morphologically matching Reed-Sternberg cells. Cytogentic analysis of mononuclear cells of the bone marrow showed normal karyotype. The patient was in clinical stage IV/V of the disease and chemotherapy with 9 cycles of ABVD+Mp protocol was applied. He is still in remission.

EXTRAVASAL FIBRIN STABILIZATION BY FACTOR XIII IN LYMPH NODES WITH HODGKIN’S DISEASE

1987 ◽  
Author(s):  
R Adày ◽  
A Szegedi ◽  
Z Nemes ◽  
L Muszbek
Keyword(s):  
Lymph Nodes ◽  
Hodgkin's Disease ◽  
Factor Xiii ◽  
Mononuclear Cells ◽  
Hodgkin’S Disease ◽  
Tumor Stroma ◽  
Urea Solution ◽  
Immunoperoxidase Technique ◽  
Long Time ◽  
Covalently Linked

The formation of extravasal fibrin deposits in various tumors has been recognized a long time ago and it has been implicated in various aspects of tumor growth. However, no adequate information is available on the nature of intratumoral fibrin. In this study we attempted to find out if fibrin deposit in human lymph nodes with Hodgkin’s disease is stabilized and made resistant to fibrinolysis by factor XIII /FXIII/ of blood coagulation. The two main tasks for FXIII in fibrin stabilization is to attach a^antiplas-min the main phyiological inhibitor of fibrinolysis to fibrin strands and crosslink fibrin chains. By double immunofluorescent labeling for fibrin and α2-antiplasmin a complete colocalization of the two antigens could be observed. A part of fibrin strands also stained for α2-antiplasmin-plasmin-complex-neoantigen revealing that α2-antiplasmin covalently linked to fibrin inhibited intratumoral fibrinolysis. The finding that immunolabeling for fibrin was preserved following the treatment of sections by concentrated urea solution clearly demonstrates that fibrin chains became crosslinked by FXIII. These results were further supported by SDS PAGE analysis of intratumoral fibrin deposits. There are two theoretical possibilities for the appearance of FXIII in the interstitial space: 1/ plasmatic FXIII can get acrossthe vessel wall when increased permeability is induced 2/ FXIII can be produced and released by certain cells of the tumorous tissue. We explored the secondpossibility by various immunomorphological and enzymcytochemical techniques. Alarge number of FXIII positive cells were detected by immunoperoxidase technique in the follicular and interfollicular region of malignant, but not in normal lymph nodes. These relatively large, multipolar, mononuclear cells possesseda macrophage-like appearance and showedANAE-positivity,i.e.,they belong to thegroup of tumor associated macrophages. FXIII containing cells were labeled by monoclonal anti-Leu M3 (a monocyte/macrophage marker), but not by anti-HLA-DR.They were often found in the immediate vicinity of malignant Hodgkin’s cells and also showed an intimate relationshipwith extravasal fibrin formation.lt is suggested that FXIII secreted byintactor released from damaged macrophages might be involved in the stabilization offibrin in the tumor stroma or around tumor cells.

The Pathology of Malignant Lymphoma in Cattle: A Study of 1113 Cases

1965 ◽  
Vol 2 (1) ◽  
pp. 68-94 ◽  
Author(s):  
Hilton A. Smith
Keyword(s):  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
Hodgkin's Disease ◽  
Plasma Cells ◽  
Hodgkin’S Disease ◽  
Neoplastic Disease ◽  
Malignant Lymphomas ◽  
Defensive Reaction ◽  
Considerable Evidence ◽  
Histological Types

About 1100 cases of malignant lymphoma were studied. Malignant lymphomas in cattle occur mostly at the older ages but they are by no means absent in the very young. Sex, breed and season of the year have little significance. Nearly all organs and tissues are susceptible to invasion, but some much more so than others, lymph nodes and heart being outstanding. Several histological types are described, as well as a relation to Hodgkin's disease. Reactions by eosinophils, plasma cells and other cells are described and an attempt made to evaluate them etiologically. Considerable evidence suggests that this neoplastic disease originates as an unsuccessful, generalized defensive reaction.

scholarly journals A case series of Kimura’s disease: a diagnostic challenge

2018 ◽  
Vol 9 (7) ◽  
pp. 207-211 ◽  
Author(s):  
Vivek Kumar ◽  
Navneet Mittal ◽  
Yiwu Huang ◽  
Jasminka Balderracchi ◽  
Huo Xiang Zheng ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Hodgkin's Disease ◽  
Immunoglobulin E ◽  
Hodgkin’S Disease ◽  
Case Series ◽  
Kimura’S Disease ◽  
Pathological Features ◽  
Diagnostic Challenge ◽  
First Case

Kimura’s disease (KD) is a rare, benign disorder characterized by subcutaneous masses with regional lymph-node enlargement. It is considered to be due to chronic inflammation of unclear etiology. Most cases have been reported in young, 20–30-year-old men of Asian descent. The diagnosis of KD is based on pathological features and elevated immunoglobulin E levels. Characteristic pathological features include intact lymph-node architecture, florid germinal center hyperplasia, extensive eosinophilic infiltrates, and proliferation of postcapillary venules. However, these features can also be seen in Hodgkin’s disease or T-cell lymphoma, therefore, cases presenting as KD pose a diagnostic challenge. We report a case series of two cases with suspected KD at initial presentation, with one patient eventually diagnosed with Hodgkin’s disease after clinical progression. The first case was a 45-year-old Asian man who presented with bilateral thigh masses and significantly enlarged inguinal lymph nodes. The histopathology was characteristic and the patient had stable disease on treatment with cetirizine for 20 months. The second case was a 29-year-old African-American man who had progressive enlargement of the right neck lymph nodes extending into the mediastinum, with the original biopsy suggestive of KD. An initial search for Reed–Sternberg cells using immunohistochemical staining for CD15 and CD30 was negative. However, the patient developed neurological symptoms corresponding to tumor extension to the cervical and thoracic neural foramina. A repeat biopsy showed a lack of nodal structure and atypical large cells that were positive for CD30 staining. The patient was treated with chemotherapy with good response. We emphasize the importance of following the clinical course to render an accurate diagnosis. Both cases showed extensive eosinophilic infiltration and other KD-like pathological features. However, KD is rare; not missing a malignant diagnosis lies in high clinical suspicion and repeated exhaustive work up.

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