Macrodantin v. standard nitrofurantoin

1974 ◽  
Vol 12 (12) ◽  
pp. 47-48

Nitrofurantoin is effective in the treatment of acute urinary tract infections, but its usefulness is limited by the high incidence of unwanted effects. When used in the recommended dose of 100 mg four times daily about a quarter of the patients may suffer nausea and vomiting.1 A single dose of 100 mg at night for the prophylaxis of urinary infections2 caused symptoms in 41% of patients.3 These unwanted effects seem to be related to peak plasma concentrations of the drug rather than to its action on the gut.

1981 ◽  
Vol 15 (10) ◽  
pp. 738-750 ◽  
Author(s):  
Neil Massoud

The treatment of urinary tract infections (UTIs) has become a complex problem for the clinical practitioner. An understanding of the pharmacology, pharmacokinetics, and in vivo biological activity of antimicrobial agents is needed, as is an understanding of the variables that may influence patient compliance with medication regimens. Although UTIs are usually treated for 10 to 14 days, shorter treatment schedules of seven to ten days or even single-dose regimens are possible. Guidelines for the treatment of UTIs are presented along with suggestions for increased patient compliance.


1983 ◽  
Vol 103 (2) ◽  
pp. 316-319 ◽  
Author(s):  
Linda Wallen ◽  
W. Patrick Zeller ◽  
Mary Goessler ◽  
Edward Connor ◽  
Ram Yogev

2000 ◽  
Vol 5 (1) ◽  
Author(s):  
G.C. ALBERTON ◽  
P.R. WERNER ◽  
J. SOBESTIANSKY ◽  
O.D. COSTA ◽  
W. BARIONI JÚNIOR

O presente trabalho teve como objetivo determinar a prevalência de infecção urinária e da bactéria Actinomyces suis na urina de 1745 porcas gestantes da região Sul do Brasil e correlacionar essa prevalência com parâmetros físicos e químicos da urina. A prevalência de infecção urinária e de A. suis foi de 28,31% e 20,63%, respectivamente. Observou-se correlação negativa entre infecção urinária e A. suis, ou seja, as porcas que apresentaram infecção urinária tinham menor prevalência de A. suis (13,67%) do que as que não a apresentaram (23,12%). Da mesma forma, as porcas portadoras de A. suis, tinham menor prevalência de infecção urinária (17,43%) do que as não portadoras (28,62%). Apenas 3,60% das porcas examinadas eram positivas para infecção urinária e A. suis simultaneamente. A cor predominante da urina foi a amarelo claro, tanto para as porcas portadoras ou não portadoras de infecção urinária ou de A. suis. Constatou-se a presença de turbidez em 83,15% das amostras, sendo que em 96,18% das amostras turvas observou-se a presença de cristais. Finalmente, a cor, aspecto, densidade, pH e presença de cristais, foram considerados como parâmetros sem valor para o diagnóstico presuntivo de infecção urinária em porcas gestantes. Prevalence of urinary tract infections and of Actinomyces suis in urine from pregnant sows. Correlation with some urine’s physical and chemical parameters Abstract A survey has been carried out in urine samples from 1745 pregnant sows from Southern Brazil, in regard to the prevalence of urinary infections and of Actinomyces suis and its correlation with some of the urine physical and chemical parameters. Prevalence of urinary infections was of 28.31% and that of A. suis, 20.63%. However, a negative correlation has been found between the incidence of urinary infection and the presence of A. suis, the prevalence of the latter being lower in sows which are positive for urinary infections (13.67%) than in those without urinary infection (23.12%). At the same time, sows positive for A. suis display a lesser number of urinary infection (17.43%) than those negative for the bacteria (28.62%). Only in 3.60% of the sows, urinary infection and A. suis occurred simultaneously. Due to the presence of crystals, turbidity was frequently observed in sow’s urine (83.15%). Crystals were present in 96.18% of sow’s turbid urine samples. Furthermore, color, turbidity, density, pH and the presence of crystals were not considered of value for the presumptive diagnosis of urinary tract infections in pregnant sows.


2019 ◽  
Vol 38 (7) ◽  
pp. 1787-1794
Author(s):  
Kathrin Bausch ◽  
Jürg Motzer ◽  
Jan A. Roth ◽  
Marc Dangel ◽  
Hans-Helge Seifert ◽  
...  

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