Potential drug interactions and side effects in an outpatient oncology clinic: a retrospective descriptive study

2014 ◽  
Vol 21 (4) ◽  
pp. 216-221 ◽  
Author(s):  
Aygin Bayraktar-Ekincioglu ◽  
Kutay Demirkan ◽  
Burcu Keskin ◽  
Oktay Aslantas ◽  
Evren Ozdemir
Keyword(s):  
Side Effects ◽  
Drug Interactions ◽  
Descriptive Study ◽  
Potential Drug

scholarly journals Management of drug interactions

2014 ◽  
Vol 1 (2) ◽  
pp. 116-120
Author(s):  
Houari Toumi ◽  
◽  
Fatima Boudia ◽  
Fatima Zohra Nadjet Mekaouche ◽  
Habiba Fetati ◽  
...  
Keyword(s):  
Side Effects ◽  
Drug Interactions ◽  
Clinical Relevance ◽  
Therapeutic Efficacy ◽  
Potential Drug

The risk of drug interactions in patients increases with the increasing number of drugs in the therapeutic regimens. To avoid or reduce them, management of these interactions is imperative. This management is to identify potential drug interactions by using the appropriate resources, to judge the clinical relevance, and to act accordingly with the prescriber. This article discusses the levels of severity of drug interactions and highlights the need for their management by presenting a part of the experience of the department of Pharmacovigilance EHU Oran. The intervention of the pharmacologist turns out beneficial by helping the clinician to manage risk associations in favor of better therapeutic efficacy and minimal side effects.

Lithium Side Effects in the Medically Ill

1993 ◽  
Vol 23 (4) ◽  
pp. 357-382 ◽  
Author(s):  
W. Alexander Morton ◽  
Susan C. Sonne ◽  
R. Bruce Lydiard
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Drug Interactions ◽  
Drug Monitoring ◽  
Geriatric Patient ◽  
Potential Drug ◽  
Medical Problems ◽  
Medically Ill ◽  
Organ Systems ◽  
General Pharmacology

Objective: This review will include the general pharmacology of lithium and discuss its effects on various organ systems, with emphasis on the medically ill patient as well as the geriatric patient with multiple medical problems. Methods: A full literature review on the side effects of lithium was performed. Attention is focused on the medically ill and possible drug interactions. Results: This review points to the numerous problems which can result in toxicity in the medically ill or the geriatric patient. Conclusion: Serious side effects can be avoided with proper drug monitoring and knowledge of potential drug interactions.

scholarly journals Drug interactions in patients with hypertension at Persahabatan hospital in 2015

2021 ◽  
pp. 309-314
Author(s):  
Zainul Islam ◽  
Atika Vitasari ◽  
Muhammad Arif Ridwan
Keyword(s):  
Drug Interactions ◽  
Medical Records ◽  
Secondary Data ◽  
Sampling Technique ◽  
Descriptive Study ◽  
Retrospective Data ◽  
Potential Drug ◽  
Literature Study ◽  
Hypertensive Disease ◽  
Hypertensive Patients

Introduction: Hypertensive disease can cause various complications, such as cardiovascular disease, stroke, diabetes mellitus, and kidney failure. To overcome these complications, patients are given polypharmacy therapy, which can potentially lead to drug interactions. Aim: The purpose of this study was to determine the potential incidence of drug interactions in hypertensive inpatients at the Persahabatan Hospital in 2015. Methods: The research is a descriptive study with retrospective data by purposive sampling technique using secondary data, medical records of hypertensive inpatients. The study of drug interactions was conducted theoretically, based on a literature study using Drug Interaction Facts 2014. Results: The results showed out of 174 hypertensive patients, 141 (81.0%) had potential drug interactions, with a total of 1444 cases. The highest drug interactions were at three levels of significance in 383 cases (26.5%), with 554 cases (38.4%) of pharmacodynamic mechanisms.

Psychopharmacology in Psychodermatology

2008 ◽  
Vol 12 (6) ◽  
pp. 255-267 ◽  
Author(s):  
Rahul Shukla ◽  
Denis Sasseville
Keyword(s):  
Side Effects ◽  
Drug Interactions ◽  
Potential Drug ◽  
Review Of The Literature ◽  
Mesh Terms ◽  
Psychotropic Agents ◽  
A Current

Background: The management of psychodermatologic disease often involves the use of psychotropics by dermatologists. A general approach to the psychopharmacologic management of psychodermatological disease may be of assistance to the dermatologist. Objective: We review and provide a current psychopharmacologically based approach to management of common psychopathologies associated with psychodermatologic disorders, common side effects, and potential drug interactions that may occur with selected psychotropics. Methods: Using relevant MeSH terms, we performed a review of the literature from 1980 to 2006. Results and Conclusions: Effective psychopharmacologic management of psychodermatologic disease involves identifying and basing treatment on the associated psychopathology; familiarity with a variety of psychotropic agents, including antidepressants, anxiolytics, and antipsychotics; and the involvement of a psychiatrist when possible.

scholarly journals IDENTIFIKASI INTERAKSI OBAT POTENSIAL PADA PASIEN STROKE RAWAT INAP DI RSUP PROF. DR. R. D. KANDOU MANADO

PHARMACON ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 639
Author(s):  
Natasia G Solang ◽  
Weny Wiyono ◽  
Deby Afriani Mpila
Keyword(s):  
Drug Interactions ◽  
Descriptive Study ◽  
Retrospective Data ◽  
Potential Drug ◽  
Stroke Therapy ◽  
Stroke Patients ◽  
Increased Risk ◽  
Retrospective Data Collection ◽  
Potential Interactions ◽  
Care Costs

ABSTRACTMost stroke patients receive polypharmacy, because most stroke patients have complications. Stroke therapy is important because if an interaction occurs, it can cause an increased risk of hospitalized patients and higher health care costs. This study is a descriptive study which aims to determine the prevalence of potential drug interactions that occur in inpatients of stroke hospitalization at Prof. Dr. R. D. Kandou Manado with retrospective data collection in October-December 2017. Samples were obtained as many as 40 patients. The results showed potential drug interactions in 20 patients (50%), with 57 potential interactions. Based on the mechanism, 30 events (52.63%) were pharmacokinetic, 15 events (26.31%) included in the pharmacokinetic and pharmacodynamic combination and 12 events (21.05%) were pharmacodynamic. The potential severity of the drug, at the moderate level was found to be 27 potential (47.36%), at the minor level 16 potential (28.07%) and at the major level with 14 potential (24.56%). Keywords: Drug Interaction, Stroke ABSTRAKKebanyakan pasien stroke menerima obat polifarmasi karena sebagian besar pasien stroke mengalami komplikasi. Terapi penyakit stroke sangat penting karena jika terjadi interaksi dapat menyebabkan peningkatan risiko pasien dirawat rawat inap dan biaya perawatan kesehatan akan lebih tinggi. Penelitian ini merupakan penelitian deskriptif yang bertujuan untuk mengetahui prevalensi interaksi obat potensial yang terjadi pada pasien stroke rawat inap di RSUP Prof. Dr. R. D. Kandou Manado dengan pengambilan data secara retrospektif pada bulan oktober-desember 2017. Sampel diperoleh sebanyak 40 pasien. Hasil penelitian menunjukan adanya interaksi obat potensial pada 20 pasien (50%), dengan jumlah potensial interaksi sebanyak 57 kejadian. Berdasarkan mekanismenya, 30 kejadian (52,63%) merupakan farmakokinetik, 15 kejadian (26,31%) termasuk dalam kombinasi farmakokinetik dan farmakodinamik dan 12 kejadian (21,05%) merupakan farmakodinamik. Tingkat keparahan potensial interaksi obat, pada tingkat moderate didapati 27 potensi (47,36%), pada tingkat minor 16 potensi (28,07%) dan pada tingkat major dengan 14 potensi (24,56%). Kata Kunci: Interaksi Obat, Stroke

OTC Orlistat Poses Potential Drug Interactions

2006 ◽  
Vol 36 (4) ◽  
pp. 8
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Drug Interactions ◽  
Potential Drug

Recent Advances in the Development of Antimicrobial Peptides (AMPs): Attempts for Sustainable Medicine?

2018 ◽  
Vol 25 (21) ◽  
pp. 2503-2519 ◽  
Author(s):  
Anne Kokel ◽  
Marianna Torok
Keyword(s):  
Side Effects ◽  
Antimicrobial Peptides ◽  
Potential Drug ◽  
Green Technologies ◽  
Specific Antibodies ◽  
Structural Modifications ◽  
Drug Candidates ◽  
Induce Resistance ◽  
Conventional Antibiotics

Background: Since the first isolation of antimicrobial peptides (AMPs) they have attracted extensive interest in medicinal chemistry. However, only a few AMP-based drugs are currently available on the market. Despite their effectiveness, biodegradability, and versatile mode of action that is less likely to induce resistance compared to conventional antibiotics, AMPs suffer from major issues that need to be addressed to broaden their use. Notably, AMPs can lack selectivity leading to side effects and cytotoxicity, and also exhibit in vivo instability. Several strategies are being actively considered to overcome the limitations that restrain the success of AMPs. Methods: In the current work, recent strategies reported for improving AMPs in the context of drug design and delivery were surveyed, and also their possible impact on patients and the environment was assessed. Results: As a major advantage AMPs possess an easily tunable skeleton offering opportunities to improve their properties. Strategic structural modifications and the beneficial properties of cyclic or branched AMPs in term of stability have been reported. The conjugation of AMPs with nanoparticles has also been explored to increase their in vivo stability. Other techniques such as the coupling of AMPs with specific antibodies aim to increase the selectivity of the potential drug towards the target. These strategies were evaluated for their effect on the environment highlighting green technologies. Conclusion: Although further research is needed taking into account both environmental and human health consequences of novel AMPs, several of these compounds are promising drug candidates for use in sustainable medicine.

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